Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma
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- 作者：Chulwon Kim ; Sang Hyun Baek ; Jae-Young Um ; Bum Sang Shim ; Kwang Seok Ahn
- 关键词：Resveratrol ; STAT3/5 ; PTPε ; SHP ; 2 ; Renal cell carcinoma
- 刊名：BMC Nephrology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：3,028 KB
- 刊物主题：Nephrology; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2369
文摘
Background Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).