The modifying effect of vitamin C on the association between perfluorinated compounds and insulin resistance in the Korean elderly: a double-blind, randomized, placebo-controlled crossover trial

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• 作者：Jin Hee Kim ; Hye Yin Park ; Jung Dae Jeon ; Younglim Kho…
• 关键词：Perfluorinated compounds ; Insulin resistance ; Oxidative stress ; Vitamin C supplementation
• 刊名：European Journal of Nutrition
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：55
• 期：3
• 页码：1011-1020
• 全文大小：633 KB
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• 作者单位：Jin Hee Kim (1)
  Hye Yin Park (2)
  Jung Dae Jeon (3)
  Younglim Kho (3)
  Seung-Kyu Kim (4)
  Min-Seon Park (5)
  Yun-Chul Hong (2) (6)
  
  1. Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea
  2. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 110-799, Republic of Korea
  3. Department of Health, Environment and Safety, Eulji University, Sungnam, Republic of Korea
  4. Department of Marine Science, College of Natural Sciences, University of Incheon, Incheon, Republic of Korea
  5. Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea
  6. Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose There is limited evidence whether environmental exposure to perfluorinated compounds (PFCs) affects insulin resistance (IR) and whether vitamin C intake protects against the adverse effect of PFCs. This study was carried out to investigate the effect of PFCs on IR through oxidative stress, and the effects of a 4-week consumption of vitamin C supplement compared placebo on development of IR by PFCs.