Anti-bacterial and cytotoxic properties of plasma sprayed silver-containing HA coatings

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• 作者：Yikai Chen ; Xuebin Zheng ; Youtao Xie ; Chuanxian Ding ; Hongjiang Ruan and Cunyi Fan
• 刊名：Journal of Materials Science Materials in Medicine
• 出版年：2008
• 出版时间：December, 2008
• 年：2008
• 卷：19
• 期：12
• 页码：3603-3609
• 全文大小：739.6 KB

文摘

Silver-containing hydroxyapatite (HA) coatings have been prepared on titanium substrate by vacuum plasma spraying (VPS) method and anti-bacterial properties of the coatings were examined. Three types of bacteria stains, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, were employed in this test. The results showed that the silver-containing HA coatings exhibited significant anti-bacterial effects against the three bacteria with anti-bacterial ratios higher than 95 % . The release of silver ions in the physiological environment ensured excellent anti-bacterial properties of the silver-containing HA coatings. International standard ISO 10993-12 was adopted for cytotoxicity evaluation using fibroblast cell line L929, and it was found that the cytotoxicity for the coatings ranked 0 that showed no cytotoxicity for the coatings. Hemolysis test was processed according to ASTM F 756 standard with anti-coagulated rabbit blood, and the hemolysis ratios of the coatings were below 0.4 % , indicating of non-hemolysis for the coatings.