Effects of glycerol on pigments and monacolin K production by the high-monacolin K-producing but citrinin-free strain, Monascus pilosus MS-1
详细信息 查看全文
- 作者：Yanli Feng ; Yanchun Shao ; Youxiang Zhou…
- 关键词：Monascus pilosus MS ; 1 ; Glycerol ; Pigments ; Monacolin K ; Citrinin
- 刊名：European Food Research and Technology
- 出版年：2015
- 出版时间：March 2015
- 年：2015
- 卷：240
- 期：3
- 页码：635-643
- 全文大小：358 KB
- 参考文献：1. Chatzifragkou A, Papanikolaou S (2012) Effect of impurities in biodiesel-derived waste glycerol on the performance and feasibility of biotechnological processes. Appl Microbiol Biotechnol 95(1):13-7 CrossRef
2. Lu LP, Zhang BB, Xu GR (2013) Efficient conversion of high concentration of glycerol to monacolin K by solid-state fermentation of / Monascus purpureus using bagasse as carrier. Bioprocess Biosyst Eng 36(3):293-99 CrossRef
3. Dobson R, Gray V, Rumbold K (2012) Microbial utilization of crude glycerol for the production of value-added products. J Ind Microbiol Biotechnol 39(2):217-26 CrossRef
4. Miyake T, Uchitomi K, Zhang MY, Kono I, Nozaki N, Sammoto H, Inagaki K (2006) Effects of the principal nutrients on lovastatin production by / Monascus pilosus. Biosci Biotech Bioch 70(5):1154-159 CrossRef
5. Tallapragada P, Dikshit R, Dessai PT (2013) Effect of glycerol as a sole carbon source on / Monascus sp. for pigment production. Int Food Res J 20(6):3265-268
6. Bühler RMM, Dutra AC, Vendruscolo F, Moritz DE, Ninow JL (2013) / Monascus pigment production in bioreactor using a co-product of biodiesel as substrate. Food Sci Technol (Campinas) 33:9-3
7. Turner WB (1971) Fungal metabolites, vol 15. Academic Press, London, pp 445-76
8. Li L, Shao YC, Li Q, Yang S, Chen FS (2010) Identification of / Mga1, a G-protein α-subunit gene involved in regulating citrinin and pigment production in / Monascus ruber M7. FEMS Microbiol Lett 308(2):108-14
9. Shi YC, Pan TM (2011) Beneficial effects of / Monascus purpureus NTU 568-fermented products: a review. Appl Microbiol Biotechnol 90(4):1207-217 CrossRef
10. J?zlová P, Martínková L, K?en V (1996) Secondary metabolites of the fungus / Monascus: a review. J Ind Microbiol Biot 16(3):163-70 CrossRef
11. Feng YL, Shao YC, Chen FS (2012) / Monascus pigments. Appl Microbiol Biotechnol 96(6):1421-440 CrossRef
12. Kim C, Jung H, Kim YO, Shin CS (2006) Antimicrobial activities of amino acid derivatives of monascus pigments. FEMS Microbiol Lett 264(1):117-24 CrossRef
13. Patakova P (2013) / Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biot 40(2):169-81 CrossRef
14. Akihisa T, Tokuda H, Ukiya M, Kiyota A, Yasukawa K, Sakamoto N, Kimura Y, Suzuki T, Takayasu J, Nishino H (2005) Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of / Monascus pilosus fermented rice (red-mold rice). Chem Biodivers 2(10):1305-309 CrossRef
15. Su NW, Lin YL, Lee MH, Ho CY (2005) Ankaflavin from / Monascus-fermented red rice exhibits selective cytotoxic effect and induces cell death on Hep G2 cells. J Agric Food Chem 53(6):1949-954 CrossRef
16. Zheng Y, Xin Y, Shi X, Guo Y (2010) Cytotoxicity of / Monascus pigments and their derivatives to human cancer cells. J Agric Food Chem 58(17):9523-528 CrossRef
17. Kim JH, Kim HJ, Kim C, Jung H, Kim YO, Ju JY, Shin CS (2007) Development of lipase inhibitors from various derivatives of / Monascus pigment produced by / Monascus fermentation. Food Chem 101(1):357-64 CrossRef
18. Kim JH, Kim HJ, Park HW, Youn SH, Choi DY, Shin CS (2007) Development of inhibitors against lipase and α-glucosidase from derivatives of / Monascus pigment. FEMS Microbiol Lett 276(1):93-8- 作者单位：Yanli Feng (1) (2) (3)
Yanchun Shao (1) (2)
Youxiang Zhou (4)
Fusheng Chen (1) (2)
1. Key Laboratory of Environment Correlative Dietology, Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People’s Republic of China
2. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei Province, People’s Republic of China
3. College of Life Sciences, Hubei Normal University, Huangshi, 435000, Hubei Province, People’s Republic of China
4. Institute of Quality Standard and Testing Technology for Agro-Products, Hubei Academy of Agricultural Sciences, Wuhan, 430070, Hubei Province, People’s Republic of China- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Food Science
Analytical Chemistry
Biotechnology
Agriculture
Forestry- 出版者：Springer Berlin / Heidelberg
- ISSN：1438-2385
- 作者单位：Yanli Feng (1) (2) (3)
文摘
Glycerol is the principal by-product of biodiesel production which can be utilized by fungi for beneficial metabolites production. In this study, effects of glycerol on main metabolites production and gene expression of pigment and monacolin K (MK) synthesis-related genes of Monascus pilosus MS-1, a high-MK-producing but citrinin-free strain, were investigated. The results indicated that addition of glycerol could increase the dry cell weight but decrease the fermentation broth pH value. Pigments production could be enhanced significantly after adding 2?g/L glycerol and the maximum pigments yield (13.78 U/mL) of fermentation broth was obtained when the glycerol content was up to 40?g/L (p?Monascus pigment. MK yield of fermentation broth was decreased significantly when the glycerol addition was up to 10?g/L while that of mycelia could be improved as glycerol addition increased (p?ctnR) for pigment synthesis were 17.31- and 22.22-folds of ctnR in the control; the gene expressions of structural gene (PKS5) for pigment synthesis were 33.27- and 60.07-folds of PKS5 in the control; respectively. However, the gene expressions of regulatory (mkH) and structural (mkA) genes of MS-1 for MK production were decreased after adding glycerol. All this suggesting that glycerol can be used for improving production of citrinin-free Monascus pigments and MK.