The Physiology of BDNF and Its Relationship with ADHD

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• 作者：De-Yi Liu ; Xue-Mei Shen ; Fang-Fen Yuan ; Ou-Yang Guo ; Yan Zhong…
• 关键词：BDNF ; Neural development ; ADHD ; Val66Met
• 刊名：Molecular Neurobiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：52
• 期：3
• 页码：1467-1476
• 全文大小：427 KB
• 参考文献：1.Huang EJ, Reichardt LF (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677鈥?36PubMed Central PubMed
  2.Barde YA, Edgar D, Thoenen H (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J 1(5):549鈥?53PubMed Central PubMed
  3.Faraone SV (1998) Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 44:951鈥?58PubMed
  4.Polanczyk G, de Lima MS, Horta BL et al (2007) The worldwide prevalence of ADHD: a systematic review and meta regression analysis. Am J Psychiatry 164(6):942鈥?48PubMed
  5.Banaschewski T, Becker K, Scherag S et al (2010) Molecular genetics of attention-deficit/hyperactivity disorder: an overview. Eur Child Adolesc Psychiatry 19(3):237鈥?57PubMed Central PubMed
  6.Kn眉sel B, Winslow JW, Rosenthal A et al (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Proc Natl Acad Sci U S A 88(3):961鈥?65PubMed Central PubMed
  7.Tsai SJ (2007) Attention-deficit hyperactivity disorder may be associated with decreased central brain-derived neurotrophic factor activity: clinical and therapeutic implications. Med Hypotheses 68(4):896鈥?99PubMed
  8.Hanson IM, Seawright A, van Heyningen V (1992) The human BDNF gene maps between FSHB and HVBS1 at the boundary of 11p13-p14. Genomics 13(4):1331鈥?333PubMed
  9.Timmusk T, Palm K, Metsis M et al (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10(3):475鈥?89PubMed
  10.Timmusk T, Belluardo N, Metsis M et al (1993) Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues. Eur J Neurosci 5(6):605鈥?13PubMed
  11.Davies AM, Wright EM (1995) Neurotrophic factors. Neurotrophin autocrine loops. Curr Biol 5(7):723鈥?26PubMed
  12.Teng KK, Hempstead BL (2004) Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci 61(1):35鈥?8PubMed
  13.Maisonpierre PC, Belluscio L, Friedman B et al (1990) NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5(4):501鈥?09PubMed
  14.Baroni A, Castellanos FX (2014) Neuroanatomic and cognitive abnormalities in attention-deficit/hyperactivity disorder in the era of 鈥榟igh definition鈥?neuroimaging. Curr Opin Neurobiol 30C:1鈥?
  15.Karege F, Schwald M, Cisse M (2002) Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328(3):261鈥?64PubMed
  16.Rios M (2013) BDNF and the central control of feeding: accidental bystander or essential player? Trends Neurosci 36(2):83鈥?0PubMed Central PubMed
  17.Mowla SJ, Farhadi HF, Pareek S et al (2001) Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276(16):12660鈥?2666PubMed
  18.Chen A, Xiong LJ, Tong Y et al (2013) The neuroprotective roles of BDNF in hypoxic ischemic brain injury. Biomed Rep 1(2):167鈥?76PubMed Central PubMed
  19.Lu B (2003) Pro-region of neurotrophins: role in synaptic modulation. Neuron 39(5):735鈥?38PubMed
  20.Pang PT, Teng HK, Zaitsev E et al (2004) Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306(5695):487鈥?91PubMed
  21.Lee R, Kermani P, Teng KK et al (2001) Regulation of cell survival by secreted proneurotrophins. Science 294(5548):1945鈥?948PubMed
  22.Corominas-Roso M, Ramos-Quiroga JA, Ribases M et al (2013) Decreased serum levels of brain-derived neurotrophic factor in adults with attention-deficit hyperactivity disorder. Int J Neuropsychopharmacol 16(06):1267鈥?275
  23.Yamamoto H, Gurney ME (1990) Human platelets contain brain-derived neurotrophic factor. J Neurosci 10(11):3469鈥?478PubMed
  24.Suter U, Heymach JV Jr, Shooter EM (1991) Two conserved domains in the NGF propeptide are necessary and sufficient for the biosynthesis of correctly processed and biologically active NGF. EMBO J 10(9):2395鈥?400PubMed Central PubMed
  25.Chen ZY, Patel PD, Sant G et al (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24(18):4401鈥?411PubMed
  26.Li H, Liu L, Tang Y et al (2014) Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-na茂ve Han Chinese sample. Psychiatry Res 217(3):191鈥?97PubMed
  27.Shim SH, Hwangbo Y, Kwon YJ et al (2008) Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD). Prog Neuro-Psychopharmacol Biol Psychiatry 32(8):1824鈥?828
  28.Porcher C, Hatchett C, Longbottom RE et al (2011) Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. J Biol Chem 286(24):21667鈥?1677PubMed Central PubMed
  29.Hsieh HY, Robertson CL, Vermehren-Schmaedick A et al (2010) Nitric oxide regulates BDNF release from nodose ganglion neurons in a pattern-dependent and cGMP-independent manner. J Neurosci Res 88(6):1285鈥?297PubMed Central PubMed
  30.Goekint M, Bos I, Heyman E et al (2012) Acute running stimulates hippocampal dopaminergic neurotransmission in rats, but has no influence on brain-derived neurotrophic factor. J Appl Physiol (1985) 112(4):535鈥?41
  31.Singh M, Meyer EM, Simpkins JW (1995) The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology 136(5):2320鈥?324PubMed
  32.Sohrabji F, Miranda RC, Toran-Allerand CD (1995) Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci U S A 92(24):11110鈥?1114PubMed Central PubMed
  33.Gall CM (1992) Regulation of brain neurotrophin expression by physiological activity. Trends Pharmacol Sci 13(11):401鈥?03PubMed
  34.Weickert CS, Hyde TM, Lipska BK (2003) Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia. Mol Psychiatry 8(6):592鈥?10PubMed
  35.Brunoni AR, Lopes M, Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11:1169鈥?180PubMed
  36.Gratac貌s M, Gonz谩lez JR, Mercader JM et al (2007) Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case鈥揷ontrol studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 61(7):911鈥?22PubMed
  37.Lanktree M, Squassina A, Krinsky M et al (2008) Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder. Am J Med Genet Part B, Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 147B(6):945鈥?51
  38.Vellucci SV, Parrott RF, Mimmack ML (2001) Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor mRNAs, in the porcine hippocampus after acute dexamethasone treatment. Res Vet Sci 70(2):157鈥?62PubMed
  39.Suri D, Vaidya VA (2013) Glucocorticoid regulation of brain-derived neurotrophic factor: relevance to hippocampal structural and functional plasticity. Neuroscience 239:196鈥?13PubMed
  40.Budziszewska B, Basta-Kaim A, Kubera M et al (2010) Immunological and endocrinological pattern in ADHD etiopathogenesis. Przegl Lek 67(11):1200鈥?204PubMed
  41.Martinowich K, Hattori D, Wu H et al (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302(5646):890鈥?93PubMed
  42.Tsankova NM, Berton O, Renthal W et al (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9(4):519鈥?25PubMed
  43.Patapoutian A, Reichardt LF (2001) Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 11(3):272鈥?80PubMed
  44.Jeong HI, Ji ES, Kim SH et al (2014) Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats. J Exerc Rehabil 10(3):162鈥?67PubMed Central PubMed
  45.Locksley RM, Killeen N, Lenardo MJ (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104(4):487鈥?01PubMed
  46.Dechant G, Barde YA (2002) The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci 5(11):1131鈥?136PubMed
  47.Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361(1473):1545鈥?564PubMed Central PubMed
  48.Bl枚chl A, Sirrenberg C (1996) Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75Lntr receptors. J Biol Chem 271(35):21100鈥?1107PubMed
  49.Barrett GL (2000) The p75 neurotrophin receptor and neuronal apoptosis. Prog Neurobiol 61(2):205鈥?29PubMed
  50.Lu B, Nagappan G, Lu Y (2014) BDNF and synaptic plasticity, cognitive function, and dysfunction. Handb Exp Pharmacol 220:223鈥?50PubMed
  51.Bramham CR, Panja D (2014) BDNF regulation of synaptic structure, function, and plasticity. Neuropharmacology 76(Pt C):601鈥?02PubMed
  52.Lesch KP, Timmesfeld N, Renner TJ et al (2008) Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transmembr 115(11):1573鈥?585
  53.Simpson PJ, Miller I, Moon C et al (2002) Atrial natriuretic peptide type C induces a cell-cycle switch from proliferation to differentiation in brain-derived neurotrophic factor- or nerve growth factor-primed olfactory receptor neurons. J Neurosci 22(13):5536鈥?551PubMed
  54.de Groot DM, Coenen AJ, Verhofstad A et al (2006) In vivo induction of glial cell proliferation and axonal outgrowth and myelination by brain-derived neurotrophic factor. Mol Endocrinol 20(11):2987鈥?998PubMed
  55.Borghesani PR, Peyrin JM, Klein R et al (2002) BDNF stimulates migration of cerebellar granule cells. Development 129(6):1435鈥?442PubMed
  56.Ohmiya M, Shudai T, Nitta A et al (2002) Brain-derived neurotrophic factor alters cell migration of particular progenitors in the developing mouse cerebral cortex. Neurosci Lett 317(1):21鈥?4PubMed
  57.Garbayo E, Raval AP, Curtis KM et al (2011) Neuroprotective properties of marrow-isolated adult multilineage-inducible cells in rat hippocampus following global cerebral ischemia are enhanced when complexed to biomimetic microcarriers. J Neurochem 119(5):972鈥?88PubMed Central PubMed
  58.Kuczewski N, Porcher C, Lessmann V et al (2009) Activity-dependent dendritic release of BDNF and biological consequences. Mol Neurobiol 39(1):37鈥?9PubMed
  59.Mizuno K, Carnahan J, Nawa H (1994) Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. Dev Biol 165(1):243鈥?56PubMed
  60.Wang T, Xie K, Lu B (1995) Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci 15(7 Pt 1):4796鈥?805PubMed
  61.Baydyuk M, Xu B (2014) BDNF signaling and survival of striatal neurons. Front Cell Neurosci 8:254PubMed Central PubMed
  62.Vithlani M, Hines RM, Zhong P et al (2013) The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor 纬2 subunit. J Neurosci 33(39):15567鈥?5577PubMed Central PubMed
  63.Granseth B, Fukushima Y, Sugo N et al (2013) Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling. Front Neural Circuits 7:202PubMed Central PubMed
  64.Aguado F, Carmona MA, Pozas E et al (2003) BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl鈭?co-transporter KCC2. Development 130(7):1267鈥?280PubMed
  65.Haraguchi S, Sasahara K, Shikimi H et al (2012) Estradiol promotes purkinje dendritic growth, spinogenesis, and synaptogenesis during neonatal life by inducing the expression of BDNF. Cerebellum 11(2):416鈥?17PubMed
  66.Luikart BW, Parada LF (2006) Receptor tyrosine kinase B-mediated excitatory synaptogenesis. Prog Brain Res 157:15鈥?4PubMed
  67.Seil FJ (2003) TrkB receptor signaling and activity-dependent inhibitory synaptogenesis. Histol Histopathol 18(2):635鈥?46PubMed
  68.Faraone SV, Perlis RH, Doyle AE et al (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57(11):1313鈥?323PubMed
  69.Egan MF, Kojima M, Callicott JH et al (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112(2):257鈥?69PubMed
  70.Hariri AR, Goldberg TE, Mattay VS et al (2003) Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23(17):6690鈥?694PubMed
  71.Szeszko PR, Lipsky R, Mentschel C et al (2005) Brain-derived neurotrophic factor Val66met polymorphism and volume of the hippocampal formation. Mol Psychiatry 10(7):631鈥?36PubMed
  72.Pezawas L, Verchinski BA, Mattay VS et al (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24(45):10099鈥?0102PubMed
  73.American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington, DC
  74.Gong Y, Cai T (1993) Chinese-Wechsler intelligence scale for children. Map Press, Hunan
  75.Kent L, Green E, Hawi Z et al (2005) Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Mol Psychiatry 10(10):939鈥?43PubMed
  76.Friedel S, Horro FF, Wermter AK et al (2005) Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet Part B Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 132B(1):96鈥?9
  77.Cho SC, Kim HW, Kim BN et al (2010) Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder. Psychiatry Investig 7(4):285鈥?90PubMed Central PubMed
  78.Xu X, Mill J, Zhou K et al (2007) Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. Am J Med Genet Part B Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 144B(1):83鈥?6
  79.Tzang RF, Hsu CD, Liou YJ et al (2013) Family-based association of the brain-derived neurotrophic factor gene in attention-deficit hyperactivity disorder. Psychiatr Genet 23(4):177鈥?78PubMed
  80.Aureli A, Del Beato T, Sebastiani P et al (2010) Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms. Int J Immunopathol Pharmacol 23(3):873鈥?80PubMed
  81.Neale BM, Lasky-Su J, Anney R et al (2008) Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B(8):1337鈥?344PubMed Central PubMed
  82.Neale BM, Medland SE, Ripke S et al (2010) Case-control genome-wide association study of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 49(9):906鈥?20PubMed Central PubMed
  83.Kernie SG, Liebl DJ, Parada LF (2000) BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19(6):1290鈥?300PubMed Central PubMed
  84.Rios M, Fan G, Fekete C et al (2001) Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15(10):1748鈥?757PubMed
  85.Linnarsson S, Bj枚rklund A, Ernfors P (1997) Learning deficit in BDNF mutant mice. Eur J Neurosci 9(12):2581鈥?587PubMed
  86.Alonso M, Vianna MR, Izquierdo I et al (2002) Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus. Cell Mol Neurobiol 22(5鈥?):663鈥?74PubMed
  87.Minichiello L, Korte M, Wolfer D et al (1999) Essential role for TrkB receptors in hippocampus-mediated learning. Neuron 24(2):401鈥?14PubMed
  88.Saarelainen T, Lukkarinen JA, Koponen S et al (2000) Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia. Mol Cell Neurosci 16(2):87鈥?6PubMed
  89.Monteggia LM, Barrot M, Powell CM et al (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci 101(29):10827鈥?0832PubMed Central PubMed
  90.Wolraich M, Brown L, Subcommittee on Attention-Deficit/Hyperactivity Disorder, Steering Committee on Quality Improvement and Management et al (2011) ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 128(5):1007鈥?022PubMed
  91.Meredith GE, Callen S, Scheuer DA (2002) Brain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administration. Brain Res 949(1鈥?):218鈥?27PubMed
  92.Heal DJ, Smith SL, Findling RL (2012) ADHD: current and future therapeutics. Curr Top Behav Neurosci 9:361鈥?90PubMed
  93.Reddy DS (2013) Current pharmacotherapy of attention deficit hyperactivity disorder. Drugs Today (Barc) 49(10):647鈥?65
  94.K眉ppers E, Beyer C (2001) Dopamine regulates brain-derived neurotrophic factor (BDNF) expression in cultured embryonic mouse striatal cells. Neuroreport 12(6):1175鈥?179PubMed
  95.Banerjee PS, Aston J, Khundakar AA et al (2009) Differential regulation of psychostimulant-induced gene expression of brain derived neurotrophic factor and the immediate-early gene arc in the juvenile and adult brain. Eur J Neurosci 29(3):465鈥?76PubMed
  96.Thomas DM, Francescutti-Verbeem DM, Liu X et al (2004) Identification of differentially regulated transcripts in mouse striatum following methamphetamine treatment鈥攁n oligonucleotide microarray approach. J Neurochem 88(2):380鈥?93PubMed
  97.Horger BA, Iyasere CA, Berhow MT et al (1999) Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor. J Neurosci 19(10):4110鈥?122PubMed
  98.Flanagin BA, Cook EH Jr, de Wit H (2006) An association study of the brain-derived neurotrophic factor Val66Met polymorphism and amphetamine response. Am J Med Genet B Neuropsychiatr Genet 141B(6):576鈥?83PubMed Central PubMed
  99.Kim BN, Cummins TD, Kim JW et al (2011) Val/Val genotype of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with a better response to OROS-MPH in Korean ADHD children. Int J Neuropsychopharmacol 14(10):1399鈥?410PubMed
  100.Cortese S (2013) Gym for the attention-deficit/hyperactivity disorder brain? Still a long run ahead. J Am Acad Child Adolesc Psychiatry 52(9):894鈥?96PubMed
  101.Rommel AS, Halperin JM, Mill J et al (2013) Protection from genetic diathesis in attention-deficit/hyperactivity disorder: possible complementary roles of exercise. J Am Acad Child Adolesc Psychiatry 52(9):900鈥?10PubMed Central PubMed
  102.Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64(2):238鈥?58PubMed Central PubMed
  103.Balaratnasingam S, Janca A (2012) Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders. Pharmacol Ther 134(1):116鈥?24PubMed
  
• 作者单位：De-Yi Liu (1)
  Xue-Mei Shen (2)
  Fang-Fen Yuan (2)
  Ou-Yang Guo (1)
  Yan Zhong (3)
  Jian-Guo Chen (4)
  Ling-Qiang Zhu (1)
  Jing Wu (2)
  
  1. Department of Pathophysiology, School of Basic Medicine, Institute of Brain Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People鈥檚 Republic of China
  2. Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People鈥檚 Republic of China
  3. Department of Child Health Care, Hunan Children鈥檚 Hospital, Changsha, 410007, People鈥檚 Republic of China
  4. Department of Pharmacology, School of Basic Medicine, Institute of Brain Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People鈥檚 Republic of China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central nervous system that plays a critical role in the physiological brain functions via its two independent receptors: tropomyosin-related kinase B (TrkB) and p75, especially in the neurodevelopment. Disrupting of BDNF and its downstream signals has been found in many neuropsychological diseases, including attention-deficit hyperactivity disorder (ADHD), a common mental disorder which is prevalent in childhood. Understanding the physiological functions of BDNF during neural development and its potential relationship with ADHD will help us to elucidate the possible mechanisms of ADHD and to develop therapeutic approaches for this disease. In this review, we summarized the important literatures for the physiological functions of BDNF in the neurodevelopment. We also performed an association study on the functional genetic variation of BDNF and ADHD by a case-control study in the Chinese mainland population and revealed the potential correlation between BDNF and ADHD which needs further research to confirm. Keywords BDNF Neural development ADHD Val66Met