Interleukin-20 Promotes Airway Remodeling in Asthma
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- 作者：Wenbin Gong (1) (2)
Xin Wang (1) (2)
Yuguo Zhang (3)
Junqing Hao (3)
Chunyan Xing (2)
Qi Chu (3)
Guicheng Wang (4)
Jiping Zhao (1)
Junfei Wang (1)
Qian Dong (1)
Tian Liu (1)
Yuanyuan Zhang (1)
Liang Dong (1) - 关键词：interleukin ; 20 ; airway remodeling ; α ; SMA ; fibronectin ; 1 ; asthma
- 刊名：Inflammation
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：37
- 期：6
- 页码：2099-2105
- 全文大小：728 KB
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16. Wu J, Liu F, Zhao J, Wei Y, Lv J, Dong F, et al. Thymic stromal lymphopoietin promotes asthmatic airway remodelling in human lung fibroblast cells through STAT3 signalling pathway. Cell biochemistry and function 2012. - 作者单位：Wenbin Gong (1) (2)
Xin Wang (1) (2)
Yuguo Zhang (3)
Junqing Hao (3)
Chunyan Xing (2)
Qi Chu (3)
Guicheng Wang (4)
Jiping Zhao (1)
Junfei Wang (1)
Qian Dong (1)
Tian Liu (1)
Yuanyuan Zhang (1)
Liang Dong (1)
1. Department of Respiratory Medicine, Qilu Hospital of Shandong University, #107, Wenhua Xi Road, Jinan, 250012, Shandong, People’s Republic of China
2. Department of Respiratory Medicine, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China
3. Gaotang County People’s Hospital, Liaocheng, Shandong, China
4. Department of Geriatrics, Taian Central Hospital, Taian, Shandong, China - ISSN：1573-2576
文摘
Previous studies have demonstrated that interleukin-20 (IL-20) is a pro-inflammatory cytokine, and it has been implicated in psoriasis, lupus nephritis, rheumatoid arthritis, atherosclerosis, and ulcerative colitis. Little is known about the effects of IL-20 in airway remodeling in asthma. The aim of our study was to demonstrate the function of IL-20 in airway remodeling in asthma. To identify the expression of IL-20 and its receptor, IL-20R1/IL-20R2, in the airway epithelium in bronchial tissues, bronchial biopsy specimens were collected from patients and mice with asthma and healthy subjects and stained with specific antibodies. To characterize the effects of IL-20 in asthmatic airway remodeling, we silenced and stimulated IL-20 in cell lines isolated from mice by shRNA and recombinant protein approaches, respectively, and detected the expression of α-SMA and FN-1 by Western blot analysis. First, overexpression of IL-20 and its receptor, IL-20R1/IL-20R2, was detected in the airway epithelium collected from patients and mice with asthma. Second, IL-20 increased the expression of fibronectin-1 and α-SMA, and silencing of IL-20 in mouse lung epithelial (MLE)-12 cells decreased the expression of fibronectin-1 and α-SMA. IL-20 may be a critical cytokine in airway remodeling in asthma. This study indicates that targeting IL-20 and/or its receptors may be a new therapeutic strategy for asthma.