New-onset systemic lupus erythematosus during pregnancy
详细信息 查看全文
- 作者：Chunmei Zhao (1)
Jijun Zhao (1)
Yuefang Huang (2)
Zilian Wang (3)
Hongyue Wang (1)
Hui Zhang (1)
Hanshi Xu (1)
Niansheng Yang (1) - 关键词：Lupus nephritis ; New onset ; Pregnancy ; Systemic lupus erythematosus
- 刊名：Clinical Rheumatology
- 出版年：2013
- 出版时间：June 2013
- 年：2013
- 卷：32
- 期：6
- 页码：815-822
- 全文大小：187KB
- 参考文献：1. Molad Y, Borkowski T, Monselise A et al (2005) Maternal and fetal outcome of lupus pregnancy: a prospective study of 29 pregnancies. Lupus 14:145-51 CrossRef
2. Clowse ME, Jamison M, Myers E, James AH (2008) A national study of the complications of lupus in pregnancy. Am J Obstet Gynecol 199:127.e1-6
3. Dhar JP, Essenmacher LM, Ager JW, Sokol RJ (2005) Pregnancy outcomes before and after a diagnosis of systemic lupus erythematosus. Am J Obstet Gynecol 193:1444-455 CrossRef
4. Clowse ME, Magder LS, Witter F, Petri M (2005) The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum 52:514-21 CrossRef
5. Silva CA, Hilario MO, Febronio MV et al (2008) Pregnancy outcome in juvenile systemic lupus erythematosus: a Brazilian multicenter cohort study. J Rheumatol 35:1414-418
6. Surita FG, Parpinelli MA, Yonehara E, Krupa F, Cecatti JG (2007) Systemic lupus erythematosus and pregnancy: clinical evolution, maternal and perinatal outcomes and placental findings. Sao Paulo Med J 125:91-5 CrossRef
7. Andrade R, Sanchez ML, Alarcon GS et al (2008) Adverse pregnancy outcomes in women with systemic lupus erythematosus from a multiethnic US cohort: LUMINA (LVI) [corrected]. Clin Exp Rheumatol 26:268-74
8. Wagner SJ, Craici I, Reed D et al (2009) Maternal and foetal outcomes in pregnant patients with active lupus nephritis. Lupus 18:342-47 CrossRef
9. Smyth A, Oliveira GH, Lahr BD, Bailey KR, Norby SM, Garovic VD (2010) A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol 5:2060-068 CrossRef
10. Bernier MO, Mikaeloff Y, Hudson M, Suissa S (2009) Combined oral contraceptive use and the risk of systemic lupus erythematosus. Arthritis Rheum 61:476-81 CrossRef
11. Costenbader KH, Feskanich D, Stampfer MJ, Karlson EW (2007) Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum 56:1251-262 CrossRef
12. Petri M, Howard D, Repke J (1991) Frequency of lupus flare in pregnancy. The Hopkins Lupus Pregnancy Center experience. Arthritis Rheum 34:1538-545 CrossRef
13. Cortes-Hernandez J, Ordi-Ros J, Paredes F, Casellas M, Castillo F, Vilardell-Tarres M (2002) Clinical predictors of fetal and maternal outcome in systemic lupus erythematosus: a prospective study of 103 pregnancies. Rheumatology (Oxford) 41:643-50 CrossRef
14. Tandon A, Ibanez D, Gladman DD, Urowitz MB (2004) The effect of pregnancy on lupus nephritis. Arthritis Rheum 50:3941-946 CrossRef
15. Lockshin MD (1989) Pregnancy does not cause systemic lupus erythematosus to worsen. Arthritis Rheum 32:665-70 CrossRef
16. Yang MJ, Cheng MH, Lin HY (2006) Onset of systemic lupus erythematosus during pregnancy. J Chin Med Assoc 69:130-33 CrossRef
17. Matsuo S, Uchida E, Shimajiri S, Nishihara G (2007) A case of a pregnant woman developing systemic lupus erythematosus during pregnancy. Clin Nephrol 67:331-32
18. Stepanková J, Bürgelova M, Honsova E, Tesar V, Vrbska J, Viklicky O (2008) Preeclampsia, dilated cardiomyopathy and renal failure as the first manifestation of systemic lupus erythematosus: a case report. Clin Rheumatol 28:343-45 CrossRef
19. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725 CrossRef
20. Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35:630-40 CrossRef
21. Buyon JP, Kalunian KC, Ramsey-Goldman R et al (1999) Assessing disease activity in SLE patients during pregnancy. Lupus 8:677-84 CrossRef
22. Verdy E, Bessous V, Dreyfus M, Kaplan C, Tchernia G, Uzan S (1997) Longitudinal analysis of platelet count and volume in normal pregnancy. Thromb Haemost 77:806-07
23. Doria A, Cutolo M, Ghirardello A et al (2002) Steroid hormones and disease activity during pregnancy in systemic lupus erythematosus. Arthritis Rheum 47:202-09 CrossRef
24. Petri M (2008) Sex hormones and systemic lupus erythematosus. Lupus 17:412-15 CrossRef
25. Doria A, Ghirardello A, Iaccarino L et al (2004) Pregnancy, cytokines, and disease activity in systemic lupus erythematosus. Arthritis Rheum 51:989-95 CrossRef
26. Doria A, Cutolo M, Ghirardello A et al (2012) Effect of pregnancy on serum cytokines in SLE patients. Arthritis Res Ther 14:R66
27. Branch DW (1992) Physiologic adaptations of pregnancy. Am J Reprod Immunol 28:120-22 CrossRef
28. Burrows RF, Kelton JG (1988) Incidentally detected thrombocytopenia in healthy mothers and their infants. N Engl J Med 319:142-45
29. Steinberg AD, Melez KA, Raveche ES et al (1979) Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum 22:1170-176 CrossRef
30. Kokeny G, Godo M, Nagy E et al (2007) Skin disease is prevented but nephritis is accelerated by multiple pregnancies in autoimmune MRL/LPR mice. Lupus 16:465-77 CrossRef
31. Sanders CL, Lucas MJ (2001) Renal disease in pregnancy. Obstet Gynecol Clin North Am 28:593-00 CrossRef
32. Jara L, Vera-Lastra O, Miranda J, Alcala M, Alvarez-Nemegyci J (2001) Prolactin in human systemic lupus erytematosus. Lupus 10:748-56 CrossRef
33. Baines MG, Millar KG, Mills P (1974) Studies of complement levels in normal human pregnancy. Obstet Gynecol 43:806-10
34. Liang MH, Socher SA, Roberts WN, Esdaile JM (1988) Measurement of systemic lupus erythematosus activity in clinical research. Arthritis Rheum 31:817-25 CrossRef
35. Defendenti C, Atzeni F, Spina MF et al (2011) Clinical and laboratory aspects of Ro/SSA-52 autoantibodies. Autoimmun Rev 10:150-54 CrossRef
36. Mecacci F, Bianchi B, Pieralli A et al (2009) Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies. Rheumatology (Oxford) 48:246-49 CrossRef
37. Salmon JE, Heuser C, Triebwasser M et al (2011) Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med 8:e1001013 - 作者单位：Chunmei Zhao (1)
Jijun Zhao (1)
Yuefang Huang (2)
Zilian Wang (3)
Hongyue Wang (1)
Hui Zhang (1)
Hanshi Xu (1)
Niansheng Yang (1)
1. Department of Rheumatolgoy, First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080, People’s Republic of China
2. Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China
3. Department of Obstetrics & Gynecology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People’s Republic of China - ISSN：1434-9949
文摘
Few studies have been published focusing on the clinical features of new-onset systemic lupus erythematosus (SLE) during pregnancy. This study examined the clinical characteristics of SLE during pregnancy or puerperium. The clinical characteristics and serological parameters of 48 patients with onset of SLE during pregnancy were retrospectively compared with those of age-matched new-onset SLE patients who were diagnosed in a period of more than 12?months without pregnancy (n--5) and age-matched preeclampsia patients (n--8). SLE tended to occur during the first and second trimesters (33 and 42?%, respectively). Lupus nephritis (LN) and severe thrombocytopenia were more commonly seen in new-onset SLE during pregnancy than in patients without pregnancy (68.8 vs 35.4?% and 25 vs 9.2?%, respectively, p-lt;-.05). However, pregnant patients had lower frequency of fever, arthritis, arthralgia, alopecia, oral ulcer, and hypocomplementemia than the nonpregnant controls (p-lt;-.05). Compared to LN patients without pregnancy (n--3), LN patients with pregnancy (n--3) had more prominent proteinuria and nephrotic syndrome (p-lt;-.05). On the other hand, when compared to patients with preeclampsia, patients with new-onset SLE during pregnancy had early onset of symptoms during gestation and were characterized by presence of fever, malar lesion, autoantibodies, hypocomplementemia, hyperuricemia, active urinary sediment, and multi-organ involvement. In conclusion, patients with their first onset of lupus during pregnancy generally have more severe disease with higher prevalence of renal and platelet involvement.