Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls
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- 作者：Xianlu Zhuo (1) (2)
Houyu Zhao (2)
Aoshuang Chang (2)
Huiping Ye (2)
Yan Zhou (1)
Yufeng Song (2)
Yinghui Tan (1) - 关键词：CYP1A1 Ile462Val ; Mouth neoplasm ; Susceptibility ; Meta ; analysis ; Polymorphism
- 刊名：Tumor Biology
- 出版年：2012
- 出版时间：December 2012
- 年：2012
- 卷：33
- 期：6
- 页码：2079-2089
- 全文大小：539KB
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Houyu Zhao (2)
Aoshuang Chang (2)
Huiping Ye (2)
Yan Zhou (1)
Yufeng Song (2)
Yinghui Tan (1)
1. Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
2. Affiliated Hospital of Guiyang Medical College, Guiyang, 550004, China - ISSN：1423-0380
文摘
Cytochrome P450 (CYP) 1A1 Ile462Val (exon7) polymorphism has been suggested to be a risk factor for several cancers. Published data on its association with oral cancer risk have generated conflicting results. Our previous meta-analysis containing data from prior to Jan 2008 regarding this issue failed to find a significant association between CYP1A1 Ile462Val variation and oral cancer susceptibility. An updated meta-analysis with eligible studies for the period up to May 2012 was conducted. Separate analyses on ethnicity and source of controls were also performed. A total of 13 case–control studies comprising 1,515 cases and 2,233 controls were lastly selected for analysis. Compared with the previous meta-analysis, the overall data also failed to indicate a significant association of CYP1A1 Ile462Val polymorphism with oral cancer risk (Val/Val vs. Ile/Ile—OR--.46; 95?% CI--.96-.24; dominant model—OR--.01; 95?% CI--.81-.25; and recessive model—OR--.46; 95?% CI--.96-.23). However, in the subgroup analysis by ethnicity, increased cancer risk was observed among Asians under the additive and recessive models (Val/Val vs. Ile/Ile—OR--.74; 95?% CI--.04-.90 and recessive model—OR--.73; 95?% CI--.04-.87), inconsistent with the previous meta-analysis. Collectively, the data of the present study suggest that CYP1A1 variant Val/Val alleles might modify the susceptibility to oral cancer among Asians. Further well-designed investigations with large sample sizes are required to confirm this conclusion.