MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells
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- 作者：Guanghui Cui (1)
Mingwei Cui (2)
Yuhang Li (1)
Youguang Liang (1)
Weihao Li (1)
Haizhou Guo (1)
Song Zhao (1) - 关键词：NSCLC ; miR ; 186 ; ROCK1 ; Proliferation ; Migration ; Invasion
- 刊名：Tumor Biology
- 出版年：2014
- 出版时间：September 2014
- 年：2014
- 卷：35
- 期：9
- 页码：8933-8937
- 全文大小：627 KB
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Mingwei Cui (2)
Yuhang Li (1)
Youguang Liang (1)
Weihao Li (1)
Haizhou Guo (1)
Song Zhao (1)
1. Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China
2. School of Basic Medical Science, Peking University Health Science Center, 100191, Beijing, China - ISSN：1423-0380
文摘
MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in human cancers. Increasing evidence shows that deregulation of miRNAs contributes to the development and progression of human non-small cell lung cancer (NSCLC). Here, we identified miR-186 as a tumor suppressor in NSCLC, which was decreased in NSCLC. Overexpression of miR-186 significantly inhibited proliferation, migration, and invasion of NSCLC cells. In addition, Rho-associated protein kinase 1 (ROCK1) was identified as a target of miR-186 in NSCLC cells. Restoration of ROCK1 remarkably reversed the tumor-suppressive effects of miR-186 on cell proliferation, migration, and invasion in NSCLC cells. Furthermore, ROCK1 was inversely correlated with miR-186 expression in NSCLC. Collectively, our data indicate that miR-186 functions as tumor suppressor in NSCLC by targeting ROCK1.