A potential inhibitory function of draxin in regulating mouse trunk neural crest migration
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- 作者：Sanbing Zhang ; Yuhong Su ; Jinbao Gao…
- 关键词：Draxin ; Axon guidance ; Trunk neural crest ; Migration ; Actin cytoskeleton ; Spinal cord
- 刊名：In Vitro Cellular & Developmental Biology - Animal
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：53
- 期：1
- 页码：43-53
- 全文大小：4574KB
- 刊物主题：Cell Biology; Developmental Biology; Stem Cells; Cell Culture; Animal Genetics and Genomics;
- 出版者：Springer US
- ISSN：1543-706X
- 卷排序：53
文摘
Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord. In the present study, we report the expression pattern of mouse draxin in the embryonic mouse trunk spinal cord. In the presence of draxin, the longest net migration length of a migrating mouse trunk neural crest cell was significantly reduced. In addition, the relative number of apolar neural crest cells increased as the draxin treatment time increased. Draxin caused actin cytoskeleton rearrangement in the migrating trunk neural crest cells. Our data suggest that draxin may regulate mouse trunk neural crest cell migration by the rearrangement of cell actin cytoskeleton and by reducing the polarization activity of these cells subsequently.