Anti-tumor effect of emodin on gynecological cancer cells

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• 作者：Yaoxian Wang ; Hui Yu ; Jin Zhang ; Xin Ge ; Jing Gao ; Yunyan Zhang…
• 关键词：Emodin ; Anti ; tumor effect ; Apoptosis ; Autophagy ; Cell cycle arrest ; Angiogenesis ; Gynecological cancer cells
• 刊名：Cellular Oncology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：38
• 期：5
• 页码：353-363
• 全文大小：3,333 KB
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• 作者单位：Yaoxian Wang (1)
  Hui Yu (2)
  Jin Zhang (3)
  Xin Ge (4)
  Jing Gao (1)
  Yunyan Zhang (1)
  Ge Lou (1)
  
  1. Department of Gynaecology, Harbin Medical University Cancer Hospital, 150 Hapin Road, Harbin, 150081, China
  2. Cardiopulmonary Function Room, Harbin Medical University Cancer Hospital, Harbin, China
  3. Department of Gynaecology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China
  4. Department of General Surgery, The Provincial Hospital of Heilongjiang, Harbin, China
  
• 刊物主题：Cancer Research; Biomedicine general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436

文摘

Purpose Although an anti-tumor effect of emodin has been reported before, its effect on human gynecological cancer cells has so far not been studied. Here, we assessed the effect of emodin on cervical cancer-derived (Hela), choriocarcinoma-derived (JAR) and ovarian cancer-derived (HO-8910) cells, and investigated the possible underlying molecular and cellular mechanisms.