Factors of Hamilton Depression Rating Scale (17 items) at 2?weeks correlated with poor outcome at 1?year in patients with ischemic stroke

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• 作者：Huaiwu Yuan (1) (2)
  Ning Zhang (1)
  Chunxue Wang (1)
  Ben Yan Luo (2)
  Yuzhi Shi (1)
  Jingjing Li (1)
  Yong Zhou (1)
  Yilong Wang (1)
  Tong Zhang (1)
  Juan Zhou (3)
  Xingquan Zhao (1)
  Yongjun Wang (1)
  
• 关键词：Depression ; Cerebrovascular disorders ; Outcome assessment ; Prospective study ; Cohort studies
• 刊名：Neurological Sciences
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：35
• 期：2
• 页码：171-177
• 全文大小：252 KB
• 作者单位：Huaiwu Yuan (1) (2)
  Ning Zhang (1)
  Chunxue Wang (1)
  Ben Yan Luo (2)
  Yuzhi Shi (1)
  Jingjing Li (1)
  Yong Zhou (1)
  Yilong Wang (1)
  Tong Zhang (1)
  Juan Zhou (3)
  Xingquan Zhao (1)
  Yongjun Wang (1)
  
  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, 100050, China
  2. Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
  3. Department of Neurology, Beijing Daxin District Hospital, Capital Medical University, Beijing, China
  
• ISSN：1590-3478

文摘

There was fewer paper about the relation between the Hamilton Depression Rating Scale (17 Items, HDRS-17) factors and stroke outcomes. Our aim was to investigate the influence of total score and factors of HDRS-17 on outcome of ischemic stroke at 1?year. A total of 1,953 patients with acute ischemic stroke were enrolled into a multicentered and prospective cohort study. The HDRS-17 was used to assess symptoms at 2?weeks after ischemic stroke. The Modified Ranking Scale (mRS) scores of 3- points and 0- points were regarded as poor outcome and benign outcome, respectively. At 1?year, 1,753 (89.8?%) patients had mRS score data. After adjusting for the confounders, patients with a total HDRS-17 score of ? had a worse outcome at 1?year (OR?=?1.62, 95?% CI 1.18-.23). Symptoms of suicide (OR?=?1.89, 95?% CI 1.27-.83), decreased or loss of interest of work (OR?=?1.89, 95?% CI 1.38-.58), retardation (OR?=?1.74, 95?% CI 1.27-.38), psychic anxiety (OR?=?1.72, 95?% CI 1.26-.34), and agitation (OR?=?1.61, 95?% CI 1.08-.40) increased the risks for poor outcome by >60?%, respectively. Depressed mood, somatic anxiety, somatic symptoms-gastrointestinal, and early insomnia also increased the risk for poor outcome by nearly 50?%, respectively. A total HDRS-17 score of ?, and suicide, decreased or loss of interest of work, anxiety, agitation, retardation, depressed mood, somatic anxiety, somatic symptoms-gastrointestinal, and early insomnia of the HDRS-17 factors at 2?weeks after ischemic stroke increase the risk for poor outcome at 1?year.