A Crossover Study of Risperidone in Children, Adolescents and Adults with Mental Retardation

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• 作者：Jessica A. Hellings ; Jennifer R. Zarcone ; R. Matthew Reese ; Maria G. Valdovinos ; Janet G. Marquis ; Kandace K. Fleming and Stephen R. Schroeder
• 关键词：Risperidone ; mental retardation ; aggression ; weight gain.
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：36
• 期：3
• 页码：401-411
• 全文大小：263 KB
• 刊物类别：Behavioral Science
• 刊物主题：Psychology
  Child and School Psychology
  Pediatrics
  
• 出版者：Springer Netherlands
• ISSN：1573-3432

文摘

Risperidone has shown safety and efficacy for aggressive and destructive behaviors in short-term studies. This longer-duration study includes a broad sample. Forty subjects, aged 8–56 years (mean=22), all with mental retardation and 36 with autism spectrum disorders participated in this 22-week crossover study, with 24 weeks of open maintenance thereafter. Of 40 subjects, 23 (57.5%) responded fully (50% decrease in Aberrant Behavior Checklist-Community Irritability subscale score), while 35 subjects (87.5%) showed a 25% decrease. Gender, mood disorder, and antiseizure medications did not alter response. Increased appetite and weight gain were common. Low dose risperidone was effective for aggressive behavior in persons with MR. More long-term studies are needed, incorporating weight control interventions.