DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands

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• 作者：Pengfei Zeng ; Limin He ; Zhenfeng Ye ; Ning Yang ; Yulan Song…
• 刊名：Transition Metal Chemistry
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：40
• 期：8
• 页码：779-787
• 全文大小：768 KB
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• 作者单位：Pengfei Zeng (1)
  Limin He (2)
  Zhenfeng Ye (1)
  Ning Yang (3)
  Yulan Song (3)
  Jiazheng Lu (1)
  
  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, People鈥檚 Republic of China
  2. Department of Pharmaceutical Engineering, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510060, People鈥檚 Republic of China
  3. Department of Clinical Pathology, First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, 510060, People鈥檚 Republic of China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Physical Chemistry
  Inorganic Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1572-901X

文摘

Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated.