One family cluster of avian influenza A(H7N9) virus infection in Shandong, China

详细信息    查看全文

• 作者：Ti Liu (11)
  Zhenqiang Bi (11)
  Xianjun Wang (11)
  Zhong Li (11)
  Shujun Ding (11)
  Zhenwang Bi (11)
  Liansen Wang (11)
  Yaowen Pei (11)
  Shaoxia Song (11)
  Shengyang Zhang (11)
  Jianxing Wang (11)
  Dapeng Sun (11)
  Bo Pang (11)
  Lin Sun (11)
  Xiaolin Jiang (11)
  Jie Lei (11)
  Qun Yuan (11)
  Zengqiang Kou (11)
  Bin Yang (11)
  Yuelong Shu (12)
  Lei Yang (12)
  Xiyan Li (12)
  Kaishun Lu (13)
  Jun Liu (13)
  Tao Zhang (13)
  Aiqiang Xu (11)
  
• 关键词：Avian Influenza A (H7N9) virus ; Epidemiology ; Infectious source
• 刊名：BMC Infectious Diseases
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：415 KB
• 参考文献：1. World Health Organization: / Background and summary of human infection with influenza A (H7N9) virus. 2013. [http://www.who.int/influenza/human_animal_interface/update_20130405/en/]
  2. National Health and Family Planning Commission: / Three confirmed cases of human infection with avian influenza A(H7N9) virus in Shanghai and Anhui. 2013. [http://www.moh.gov.cn/mohwsyjbgs/s3578/201303/44f25bd6bed14cf082512d8b6258fb3d.shtml]
  3. Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, / et al.: Human infection with a novel avian-origin influenza A (H7N9) virus. / N Engl J Med 2013, 368:1888-897. CrossRef
  4. National Health and Family Planning Commission: / Human infections with avian influenza A (H7N9) virus in September, 2013. 2013. [http://www.nhfpc.gov.cn/yjb/s3578/201310/1ca7a35a2be54b3fa2c24ef45dade1b5.shtml]
  5. Gao HN, Lu HZ, Cao B, Du B, Shang H, Gan JH, Lu SH, Yang YD, Fang Q, Shen YZ, Xi XM, Gu Q, Zhou XM, Qu HP, Yan Z, Li FM, Zhao W, Gao ZC, Wang GF, Ruan LX, Wang WH, Ye J, Cao HF, Li XW, Zhang WH, Fang XC, He J, Liang WF, Xie J, Zeng M, / et al.: Clinical findings in 111 cases of influenza A (H7N9) virus infection. / N Engl J Med 2013, 368:2277-285. CrossRef
  6. Shi J, Deng G, Liu P, Zhou J, Guan L, Li W, Li XY, Guo J, Wang GJ, Fan J, Wang JL, Li YY, Jiang YP, Liu LL, Tian GB, Li CJ, Chen HL: Isolation and characterization of H7N9 viruses from live poultry markets—implication of the source of current H7N9 infection in humans. / Chin Sci Bull 2013, 58:1857-863. CrossRef
  7. Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY: Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. / Lancet 2013, 381:1916-925. CrossRef
  8. Bao CJ, Cui LB, Zhou MH, Hong L, Gao GF, Wang H: Live-animal markets and influenza A (H7N9) virus infection. / N Engl J Med 2013, 368:2337-339. CrossRef
  9. Li J, Yu X, Pu X, Xie L, Sun Y, Xiao H, Wang F, Din H, Wu Y, Liu D, Zhao G, Liu J, Pan J: Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human. / Sci China Life Sci 2013, 56:485-92. CrossRef
  10. Hongjie Y, Wu JT, Cowling BJ, Qiaohong L, Fang VJ, Sheng Z, Peng W, Hang Z, Lau EHY, Danhuai G, Ni MY, Zhibin P, Luzhao F, Hui J, Huiming L, Qun L, Zijian F, Yu W, Weizhong Y, Leung GM: Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study. / Lancet 2013. doi:10.1016/S0140-736(13)61904-
  11. Li Q, Zhou L, Zhou M, Chen Z, Li F, Wu H, Xiang N, Chen E, Tang F, Wang D, Meng L, Hong Z, Tu W, Cao Y, Li L, Ding F, Liu B, Wang M, Xie R, Gao R, Li X, Bai T, Zou S, He J, Hu J, Xu Y, Chai C, Wang S, Gao Y, Jin L, / et al.: Preliminary report: epidemiology of the avian influenza A (H7N9) outbreak in China. / N Engl J Med 2013. doi:10.1056/NEJMoa1304617
  12. Qi X, Qian YH, Bao CJ, Guo XL, Cui LB, Tang FY, Ji H, Huang Y, Cai PQ, Lu B, Xu K, Shi C, Zhu FC, Zhou MH, Wang H: Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. / BMJ 2013, 347:f4752. CrossRef
  13. Tian B, Jianfang Z, Yuelong S: Serologic study for Influenza A (H7N9) among high-risk groups in China. / N Engl J Med 2013. doi:10.1056/NEJMc1305865
  14. Kandun IN, Wibisono H, Sedyaningsih ER, Yusharmen , Hadisoedarsuno W, Purba W, Santoso H, Septiawati C, Tresnaningsih E, Heriyanto B, Yuwono D, Harun S, Soeroso S, Giriputra S, Blair PJ, Jeremijenko A, Kosasih H, Putnam SD, Samaan G, Silitonga M, Chan KH, Poon LL, Lim W, Klimov A, Lindstrom S, Guan Y, Donis R, Katz J, Cox N, Peiris M, / et al.: Three Indonesian clusters of H5N1 virus infection in 2005. / N Engl J Med 2006, 355:2186-194. CrossRef
  15. / Three samples were detected for H7N9 virus in Zaozhuang City which came from the same market. 2013. [http://www.sd.xinhuanet.com/news/2013-05/06/c_115644619.htm]
  16. Zhang Q, Shi J, Deng G, Guo J, Zeng X, He X, Kong H, Gu C, Li X, Liu J, Wang G, Chen Y, Liu L, Liang L, Li Y, Fan J, Wang J, Li W, Guan L, Li Q, Yang H, Chen P, Jiang L, Guan Y, Xin X, Jiang Y, Tian G, Wang X, Qiao C, Li C, / et al.: H7N9 influenza viruses are transmissible in Ferrets by respiratory droplet. / Science 2013,341(6144):410-14. doi: 10.1126/science.1240532 CrossRef
  17. Wang H, Feng Z, Shu Y, Yu H, Zhou L, Zu R, Huai Y, Dong J, Bao C, Wen L, Wang H, Yang P, Zhao W, Dong L, Zhou M, Liao Q, Yang H, Wang M, Lu X, Shi Z, Wang W, Gu L, Zhu F, Li Q, Yin W, Yang W, Li D, Uyeki TM, Wang Y: Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China. / Lancet 2008, 371:1427-434. CrossRef
  18. Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, Puthavathana P, Uiprasertkul M, Boonnak K, Pittayawonganon C, Cox NJ, Zaki SR, Thawatsupha P, Chittaganpitch M, Khontong R, Simmerman JM, Chunsutthiwat S: Probable person-to-person transmission of avian influenza A (H5N1). / N Engl J Med 2005, 352:333-40. CrossRef
  19. Cowling BJ, Jin L, Lau EH, Liao Q, Wu P, Jiang H, Tsang TK, Zheng J, Fang VJ, Chang Z, Ni MY, Zhang Q, Ip DK, Yu J, Li Y, Wang L, Tu W, Meng L, Wu JT, Luo H, Li Q, Shu Y, Li Z, Feng Z, Yang W, Wang Y, Leung GM, Yu H: Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. / Lancet 2013, 382:129-37. CrossRef
  20. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2334/14/98/prepub
  
• 作者单位：Ti Liu (11)
  Zhenqiang Bi (11)
  Xianjun Wang (11)
  Zhong Li (11)
  Shujun Ding (11)
  Zhenwang Bi (11)
  Liansen Wang (11)
  Yaowen Pei (11)
  Shaoxia Song (11)
  Shengyang Zhang (11)
  Jianxing Wang (11)
  Dapeng Sun (11)
  Bo Pang (11)
  Lin Sun (11)
  Xiaolin Jiang (11)
  Jie Lei (11)
  Qun Yuan (11)
  Zengqiang Kou (11)
  Bin Yang (11)
  Yuelong Shu (12)
  Lei Yang (12)
  Xiyan Li (12)
  Kaishun Lu (13)
  Jun Liu (13)
  Tao Zhang (13)
  Aiqiang Xu (11)
  
  11. Shandong Provincial Center for Disease Control and Prevention; Shandong Provincial Key Laboratory of Infectious Diseases Control and Prevention, Academy of Preventive Medicine, Shandong University, Jinan, 250014, Shandong, China
  12. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
  13. Zaozhuang Center for Disease Control and Prevention, Zaozhuang, Shandong, China
  
• ISSN：1471-2334

文摘

Background The first case of human infection with avian influenza A (H7N9) virus was identified in March, 2013 and the new H7N9 virus infected 134 patients and killed 45 people in China as of September 30, 2013. Family clusters with confirmed or suspected the new H7N9 virus infection were previously reported, but the family cluster of H7N9 virus infection in Shandong Province was first reported. Case presentation A 36-year-old man was admitted to Zaozhuang City Hospital with progressive respiratory distress and suspicion of impending acute respiratory distress syndrome on April 21. The chest radiography revealed bilateral ground-glass opacities and pulmonary lesions. The second case, the first case’s 4 year old son, was admitted to the same hospital on April 28 with fever and multiple patchy shadows in the bilateral lungs. Both of the two cases were confirmed to infect with H7N9 virus by the results of real-time reverse transcriptase-polymerase-chain reaction (rRT-PCR), virus isolation and serum antibody titer. At the same time, one environment samples was detected positive for H7N9 virus in the living poultry market in Zaozhuang. The homologous analysis of the full genome sequence indicated that both viruses from the patients were almost genetically identical. The field epidemiology investigation showed that the two cases had no recognized exposure to poultry, but had the exposure to the environment. The second case had substantial unprotected close exposure to his ill father and developed symptoms seven days after his last contact with his father. After surgery, the index case and his son were discharged on May 16 and May 6, respectively. 11 close contacts of both patients were identified and tested negative both the throat swabs and the serum antibody. Conclusion The infection of the index case probably resulted from contact with environmentally contaminated material. For the son, the probable infection source was from the index case during unprotected exposure, but the possibility from the environment or other sources could not be completely ruled out.