Altered relationship between thickness and intrinsic activity amplitude in generalized tonic–clonic seizures

详细信息    查看全文

• 作者：Wei Liao ; Jue Wang ; Ting Xu ; Zhiqiang Zhang ; Gong-Jun Ji ; Qiang Xu…
• 关键词：Cortex thickness ; Generalized tonic–clonic seizures ; Intrinsic brain activity amplitude ; Morphometric–functional relationship ; Resting state
• 刊名：Science Bulletin
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：61
• 期：24
• 页码：1865-1875
• 全文大小：
• 刊物主题：Science, Humanities and Social Sciences, multidisciplinary; Life Sciences, general; Physics, general; Chemistry/Food Science, general; Earth Sciences, general; Engineering, general;
• 出版者：Science China Press
• ISSN：2095-9281
• 卷排序：61

文摘

A thinner cortex has higher potential for binding GABA receptor A which is associated with larger amplitudes of intrinsic brain activity (iBA). However, the relationship between cortical thickness and iBA is unknown in intact and epileptic brains. To this end, we investigated the relationship between cortical thickness measured by high-resolution MRI and surface-based iBA derived from resting-state functional MRI in normal controls (n = 82) and patients with generalized tonic–clonic seizures (GTCS) only (n = 82). We demonstrated that the spatial distribution of cortical thickness negatively correlated with surface-based iBA amplitude at both whole-brain and within independent brain functional networks. In GTCS patients, spatial coupling between thickness and iBA amplitude decreased in the default mode, dorsal attention, and somatomotor networks. In addition, the vertex-wise across-subject thickness–iBA amplitude correspondence altered in the frontal and temporal lobes as well as in the precuneus in GTCS patients. The relationship between these two modalities can serve as a brain-based marker for detecting epileptogenic changes.