Transcriptional regulation of human sperm-associated antigen 16 gene by S-SOX5

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• 作者：Ling Zhang ; Yunhao Liu ; Wei Li ; Qiaoling Zhang ; Yanwei Li…
• 关键词：S ; SOX5 ; SPAG16L ; Transcriptional regulation ; Central apparatus ; Cilia
• 刊名：BMC Molecular Biology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：1493KB
• 刊物主题：Biochemistry, general; Nucleic Acid Chemistry; Cell Biology;
• 出版者：BioMed Central
• ISSN：1471-2199
• 卷排序：18

文摘

BackgroundThe mammalian sperm-associated antigen 16 gene (Spag16) uses alternative promoters to produce two major transcript isoforms (Spag16L and Spag16S) and encode proteins that are involved in the cilia/flagella formation and motility. In silico analysis of both mouse and human SPAG16L promoters reveals the existence of multiple putative SOX5 binding sites. Given that the SOX5 gene encodes a 48-kDa transcription factor (S-SOX5) and the presence of putative SOX5 binding sites at the SPAG16L promoter, regulation of SPAG16L expression by S-SOX5 was studied in the present work.