A study on the expression of erbB4/HER4 in non-small cell lung cancer
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- 作者：Zaichun Deng (1)
Wenying Yu (1)
Guoping Hu (1)
Ruheng Zheng (2)
Dunhua Zhang (2)
Yunshan Tan (2)
Yonghua Xu (3)
Wanli Jiang (3) - 关键词：erbB4 gene ; HER4 protein ; non ; small cell lung cancer
- 刊名：The Chinese-German Journal of Clinical Oncology
- 出版年：2008
- 出版时间：February 2008
- 年：2008
- 卷：7
- 期：2
- 页码：75-77
- 全文大小：140KB
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Wenying Yu (1)
Guoping Hu (1)
Ruheng Zheng (2)
Dunhua Zhang (2)
Yunshan Tan (2)
Yonghua Xu (3)
Wanli Jiang (3)
1. The Affiliated Hospital of Ningbo University, Ningbo, 315020, China
2. Zhongshan Hospital, Fudan University, Shanghai, 200032, China
3. Shanghai Institute of Cellular Biology, Chinese Academy of Sciences, Shanghai, 200032, China
文摘
Objective To test the expression of HER4 in non-small cell lung cancer (NSCLC) and elucidate the relationship between its over-expression and the clinical pathology of NSCLC. Methods 70 cases of paraffin-embedded tissues from informative NSCLC were tested for the expression of HER4 by means of immunohistochemical assay. Results HER4 were overexpressed in NSCLC in 91.4%. The overexpression of HER4 correlated only with the lymph node metastasis, TNM staging and survival after operation. Conclusion ErbB4 is one of the genes to regulate the growth of NSCLC in advanced stages and artificial interference of the overexpression of HER4 in NSCLC might be a good way for the treatment of NSCLC in advanced stages.