Oxidized graphene-aggravated allergic asthma is antagonized by antioxidant vitamin E in Balb/c mice

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• 作者：Shuai Shang ; Jinquan Li ; Yun Zhao ; Zhuge Xi…
• 关键词：Graphene oxide ; Allergic asthma ; Exacerbation effect ; Oxidative stress ; Vitamin E
• 刊名：Environmental Science and Pollution Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：24
• 期：2
• 页码：1784-1793
• 全文大小：
• 刊物类别：Earth and Environmental Science
• 刊物主题：Environment, general; Environmental Chemistry; Ecotoxicology; Environmental Health; Atmospheric Protection/Air Quality Control/Air Pollution; Waste Water Technology / Water Pollution Control / Water M
• 出版者：Springer Berlin Heidelberg
• ISSN：1614-7499
• 卷排序：24

文摘

Nanomaterials have been widely used in a number of applications; however, these nanomaterials may potentially be risky for human health, particularly for the respiratory system. In this study, we used a mouse asthma model to study whether graphene oxide (GO), a promising carbonaceous nanomaterial with unique physicochemical properties, aggravates allergic asthma via the oxidative stress pathway. Mice were sensitized with ovalbumin (OVA) to trigger immune reactions, while vitamin E (Ve) was administered as an antioxidant. Our results showed that GO aggravated OVA-induced allergic asthma in mice, as suggested by increased reactive oxygen species (ROS), elevated total immunoglobulin E (IgE), upregulated Th2 response, and the aggravation of allergic asthma symptoms, such as airway remolding, collagen deposition with mucus hypersecretion, and airway hyperresponsiveness (AHR). The administration of Ve dramatically attenuated all of the above effects. In conclusion, Ve showed anti-allergic properties in antagonizing the exacerbation of allergic asthma induced by GO, providing a new possibility for the treatment of allergic asthma.