Association between the FTOrs8050136 polymorphism and cancer risk: a meta-analysis

详细信息    查看全文

• 作者：Jian Zhao ; Xiaoyi Huang ; Mingyuan Yang ; Ming Li ; Jianming Zheng
• 关键词：FTO ; Polymorphism ; Cancer ; rs8050136 ; Meta ; analysis ; IVSA1 ; 27777C> ; A
• 刊名：Familial Cancer
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：15
• 期：1
• 页码：145-153
• 全文大小：856 KB
• 参考文献：1.Soerjomataram I, Lortet-Tieulent J, Parkin DM, Ferlay J, Mathers C, Forman D, Bray F (2012) Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions. Lancet 380(9856):1840–1850. doi:10.​1016/​s0140-6736(12)60919-2 PubMed CrossRef
  2.Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer J Int du Cancer 136(5):E359–E386. doi:10.​1002/​ijc.​29210 CrossRef
  3.Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, Fabian CJ, Gucalp A, Hershman DL, Hudson MM, Jones LW, Kakarala M, Ness KK, Merrill JK, Wollins DS, Hudis CA (2014) American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol 32(31):3568–3574PubMed CrossRef
  4.Naghavi M, Wang H, Lozano R, Davis A, Liang X, Zhou M, Vollset SE, Ozgoren AA, Abdalla S, Abd-Allah F, Abdel Aziz MI, Abera SF, Aboyans V, Abraham B, Abraham JP, Abuabara KE, Abubakar I, Abu-Raddad LJ, Abu-Rmeileh NM, Achoki T, Adelekan A, Ademi Z, Adofo K, Adou AK, Adsuar JC, Ärnlov J, Agardh EE, Akena D, Al Khabouri MJ, Alasfoor D, Albittar M, Alegretti MA, Aleman AV, Alemu ZA, Alfonso-Cristancho R, Alhabib S, Ali MK, Ali R, Alla F, Al Lami F, Allebeck P, AlMazroa MA, Al-Shahi Salman R, Alsharif U, Alvarez E, Alviz-Guzman N, Amankwaa AA, Amare AT, Ameli O, Amini H, Ammar W, Anderson HR, Anderson BO, Antonio CA, Anwari P, Apfel H, Argeseanu Cunningham S, Arsic Arsenijevic VS, Artaman A, Asad MM, Asghar RJ, Assadi R, Atkins LS, Atkinson C, Badawi A, Bahit MC, Bakfalouni T, Balakrishnan K, Balalla S, Banerjee A, Barber RM, Barker-Collo SL, Barquera S, Barregard L, Barrero LH, Barrientos-Gutierrez T, Basu A, Basu S, Basulaiman MO, Beardsley J, Bedi N, Beghi E, Bekele T, Bell ML, Benjet C, Bennett DA, Bensenor IM, Benzian H, Bertozzi-Villa A, Beyene TJ, Bhala N, Bhalla A, Bhutta ZA, Bikbov B, Bin Abdulhak A, Biryukov S, Blore JD, Blyth FM, Bohensky MA, Borges G, Bose D, Boufous S, Bourne RR, Boyers LN, Brainin M, Brauer M, Brayne CE, Brazinova A, Breitborde N, Brenner H, Briggs AD, Brown JC, Brugha TS, Buckle GC, Bui LN, Bukhman G, Burch M, Campos Nonato IR, Carabin H, Cárdenas R, Carapetis J, Carpenter DO, Caso V, Castañeda-Orjuela CA, Castro RE, Catalá-López F, Cavalleri F, Chang JC, Charlson FC, Che X, Chen H, Chen Y, Chen JS, Chen Z, Chiang PP, Chimed-Ochir O, Chowdhury R, Christensen H, Christophi CA, Chuang TW, Chugh SS, Cirillo M, Coates MM, Coffeng LE, Coggeshall MS, Cohen A, Colistro V, Colquhoun SM, Colomar M, Cooper LT, Cooper C, Coppola LM, Cortinovis M, Courville K, Cowie BC, Criqui MH, Crump JA, Cuevas-Nasu L, da Costa Leite I, Dabhadkar KC, Dandona L, Dandona R, Dansereau E, Dargan PI, Dayama A, De la Cruz-Góngora V, de la Vega SF, De Leo D, Degenhardt L, del Pozo-Cruz B, Dellavalle RP, Deribe K, Des Jarlais DC, Dessalegn M, deVeber GA, Dharmaratne SD, Dherani M, Diaz-Ortega JL, Diaz-Torne C, Dicker D, Ding EL, Dokova K, Dorsey ER, Driscoll TR, Duan L, Duber HC, Durrani AM, Ebel BE, Edmond KM, Ellenbogen RG, Elshrek Y, Ermakov SP, Erskine HE, Eshrati B, Esteghamati A, Estep K, Fürst T, Fahimi S, Fahrion AS, Faraon EJ, Farzadfar F, Fay DF, Feigl AB, Feigin VL, Felicio MM, Fereshtehnejad SM, Fernandes JG, Ferrari AJ, Fleming TD, Foigt N, Foreman K, Forouzanfar MH, Fowkes FG, Paleo UF, Franklin RC, Futran ND, Gaffikin L, Gambashidze K, Gankpé FG, García-Guerra FA, Garcia AC, Geleijnse JM, Gessner BD, Gibney KB, Gillum RF, Gilmour S, Ginawi IA, Giroud M, Glaser EL, Goenka S, Gomez Dantes H, Gona P, Gonzalez-Medina D, Guinovart C, Gupta R, Gupta R, Gosselin RA, Gotay CC, Goto A, Gouda HN, Graetz N, Greenwell KF, Gugnani HC, Gunnell D, Gutiérrez RA, Haagsma J, Hafezi-Nejad N, Hagan H, Hagstromer M, Halasa YA, Hamadeh RR, Hamavid H, Hammami M, Hancock J, Hankey GJ, Hansen GM, Harb HL, Harewood H, Haro JM, Havmoeller R, Hay RJ, Hay SI, Hedayati MT, Heredia Pi IB, Heuton KR, Heydarpour P, Higashi H, Hijar M, Hoek HW, Hoffman HJ, Hornberger JC, Hosgood HD, Hossain M, Hotez PJ, Hoy DG, Hsairi M, Hu G, Huang JJ, Huffman MD, Hughes AJ, Husseini A, Huynh C, Iannarone M, Iburg KM, Idrisov BT, Ikeda N, Innos K, Inoue M, Islami F, Ismayilova S, Jacobsen KH, Jassal S, Jayaraman SP, Jensen PN, Jha V, Jiang G, Jiang Y, Jonas JB, Joseph J, Juel K, Kabagambe EK, Kan H, Karch A, Karimkhani C, Karthikeyan G, Kassebaum N, Kaul A, Kawakami N, Kazanjan K, Kazi DS, Kemp AH, Kengne AP, Keren A, Kereselidze M, Khader YS, Khalifa SE, Khan EA, Khan G, Khang YH, Kieling C, Kinfu Y, Kinge JM, Kim D, Kim S, Kivipelto M, Knibbs L, Knudsen AK, Kokubo Y, Kosen S, Kotagal M, Kravchenko MA, Krishnaswami S, Krueger H, Kuate Defo B, Kuipers EJ, Kucuk Bicer B, Kulkarni C, Kulkarni VS, Kumar K, Kumar RB, Kwan GF, Kyu H, Lai T, Lakshmana Balaji A, Lalloo R, Lallukka T, Lam H, Lan Q, Lansingh VC, Larson HJ, Larsson A, Lavados PM, Lawrynowicz AE, Leasher JL, Lee JT, Leigh J, Leinsalu M, Leung R, Levitz C, Li B, Li Y, Li Y, Liddell C, Lim SS, de Lima GM, Lind ML, Lipshultz SE, Liu S, Liu Y, Lloyd BK, Lofgren KT, Logroscino G, London SJ, Lortet-Tieulent J, Lotufo PA, Lucas RM, Lunevicius R, Lyons RA, Ma S, Machado VM, MacIntyre MF, Mackay MT, MacLachlan JH, Magis-Rodriguez C, Mahdi AA, Majdan M, Malekzadeh R, Mangalam S, Mapoma CC, Marape M, Marcenes W, Margono C, Marks GB, Marzan MB, Masci JR, Mashal MT, Masiye F, Mason-Jones AJ, Matzopolous R, Mayosi BM, Mazorodze TT, McGrath JJ, McKay AC, McKee M, McLain A, Meaney PA, Mehndiratta MM, Mejia-Rodriguez F, Melaku YA, Meltzer M, Memish ZA, Mendoza W, Mensah GA, Meretoja A, Mhimbira FA, Miller TR, Mills EJ, Misganaw A, Mishra SK, Mock CN, Moffitt TE, Mohamed Ibrahim N, Mohammad KA, Mokdad AH, Mola GL, Monasta L, Monis Jde L, Montañez Hernandez JC, Montico M, Montine TJ, Mooney MD, Moore AR, Moradi-Lakeh M, Moran AE, Mori R, Moschandreas J, Moturi WN, Moyer ML, Mozaffarian D, Mueller UO, Mukaigawara M, Mullany EC, Murray J, Mustapha A, Naghavi P, Naheed A, Naidoo KS, Naldi L, Nand D, Nangia V, Narayan KM, Nash D, Nasher J, Nejjari C, Nelson RG, Neuhouser M, Neupane SP, Newcomb PA, Newman L, Newton CR, Ng M, Ngalesoni FN, Nguyen G, Nguyen Nt, Nisar MI, Nolte S, Norheim OF, Norman RE, Norrving B, Nyakarahuka L, Odell S, O'Donnell M, Ohkubo T, Ohno SL, Olusanya BO, Omer SB, Opio JN, Orisakwe OE, Ortblad KF, Ortiz A, Otayza ML, Pain AW, Pandian JD, Panelo CI, Panniyammakal J, Papachristou C, Paternina Caicedo AJ, Patten SB, Patton GC, Paul VK, Pavlin B, Pearce N, Pellegrini CA, Pereira DM, Peresson SC, Perez-Padilla R, Perez-Ruiz FP, Perico N, Pervaiz A, Pesudovs K, Peterson CB, Petzold M, Phillips BK, Phillips DE, Phillips MR, Plass D, Piel FB, Poenaru D, Polinder S, Popova S, Poulton RG, Pourmalek F, Prabhakaran D, Qato D, Quezada AD, Quistberg DA, Rabito F, Rafay A, Rahimi K, Rahimi-Movaghar V, Rahman SU, Raju M, Rakovac I, Rana SM, Refaat A, Remuzzi G, Ribeiro AL, Ricci S, Riccio PM, Richardson L, Richardus JH, Roberts B, Roberts DA, Robinson M, Roca A, Rodriguez A, Rojas-Rueda D, Ronfani L, Room R, Roth GA, Rothenbacher D, Rothstein DH, Rowley JT, Roy N, Ruhago GM, Rushton L, Sambandam S, Søreide K, Saeedi MY, Saha S, Sahathevan R, Sahraian MA, Sahle BW, Salomon JA, Salvo D, Samonte GM, Sampson U, Sanabria JR, Sandar L, Santos IS, Satpathy M, Sawhney M, Saylan M, Scarborough P, Schöttker B, Schmidt JC, Schneider IJ, Schumacher AE, Schwebel DC, Scott JG, Sepanlou SG, Servan-Mori EE, Shackelford K, Shaheen A, Shahraz S, Shakh-Nazarova M, Shangguan S, She J, Sheikhbahaei S, Shepard DS, Shibuya K, Shinohara Y, Shishani K, Shiue I, Shivakoti R, Shrime MG, Sigfusdottir ID, Silberberg DH, Silva AP, Simard EP, Sindi S, Singh JA, Singh L, Sioson E, Skirbekk V, SliwaK, So S, Soljak M, Soneji S, Soshnikov SS, Sposato LA, Sreeramareddy CT, Stanaway JD, Stathopoulou VK, Steenland K, Stein C, Steiner C, Stevens A, Stöckl H, Straif K, Stroumpoulis K, Sturua L, Sunguya BF, Swaminathan S, Swaroop M, Sykes BL, Tabb KM, Takahashi K, Talongwa RT, Tan F, Tanne D, Tanner M, Tavakkoli M, Ao BT, Teixeira CM, Templin T, Tenkorang EY, Terkawi AS, Thomas BA, Thorne-Lyman AL, Thrift AG, Thurston GD, Tillmann T, Tirschwell DL, Tleyjeh IM, Tonelli M, Topouzis F, Towbin JA, Toyoshima H, Traebert J, Tran BX, Truelsen T, Trujillo U, Trillini M, Tsala Dimbuene Z, Tsilimbaris M, Tuzcu EM, Ubeda C, Uchendu US, Ukwaja KN, Undurraga EA, Vallely AJ, van de Vijver S, van Gool CH, Varakin YY, Vasankari TJ, Vasconcelos AM, Vavilala MS, Venketasubramanian N, Vijayakumar L, Villalpando S, Violante FS, Vlassov VV, Wagner GR, Waller SG, Wang J, Wang L, Wang X, Wang Y, Warouw TS, Weichenthal S, Weiderpass E, Weintraub RG, Wenzhi W, Werdecker A, Wessells KR, Westerman R, Whiteford HA, Wilkinson JD, Williams TN, Woldeyohannes SM, Wolfe CD, Wolock TM, Woolf AD, Wong JQ, Wright JL, Wulf S, Wurtz B, Xu G, Yang YC, Yano Y, Yatsuya H, Yip P, Yonemoto N, Yoon SJ, Younis M, Yu C, Yun Jin K, Zaki Mel S, Zamakhshary MF, Zeeb H, Zhang Y, Zhao Y, Zheng Y, Zhu J, Zhu S, Zonies D, Zou XN, Zunt JR, Vos T, Lopez AD, Murray CJ (2015) Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. doi:10.​1016/​S0140-6736(14)61682-2
  5.Gutierrez-Ardila MV, Vargas Zea N, Pfizer SAS (2014) Contribution of health economics & outcomes research studies of Colombia to ISPOR conferences. Value Health 17(3):A27CrossRef
  6.Li S, Zhao X, Wu Z, Li Y, Zhu L, Cui B, Dong X, Tian S, Hu F, Zhao Y (2013) Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer. Fam Cancer 12(4):755–765. doi:10.​1007/​s10689-013-9659-2 PubMed CrossRef
  7.James PA, Sawyer S, Boyle S, Young M-A, Kovalenko S, Doherty R, McKinley J, Alsop K, Beshay V, Harris M, Fox S, Lindeman GJ, Mitchell G (2015) Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features. Fam Cancer 14(2):287–295. doi:10.​1007/​s10689-015-9785-0 PubMed CrossRef
  8.Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJF, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CNA, Doney ASF, Morris AD, Smith GD, Hattersley AT, McCarthy MI (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316(5826):889–894PubMed PubMedCentral CrossRef
  9.Zermeno-Rivera JJ, Astocondor-Perez JP, Valle Y, Padilla-Gutierrez JR, Orozco-Castellanos R, Figuera LE, Gutierrez-Amavizca BE (2014) Association of the FTO gene SNP rs17817449 with body fat distribution in Mexican women. Genet Mol Res 13(4):8561–8567PubMed CrossRef
  10.Madubedube J, Yako Y, Erasmus R, Kengne A, Matsha T (2014) Association study to evaluate the effects of ENPP1, FTO and TCF7L2 polymorphisms on type 2 diabetes risk in mixed-ancestry South Africans. Clin Chem Lab Med 52:S682
  11.Ikels K, Kuschel S, Fischer J, Kaisers W, Eberhard D, Ruther U (2014) FTO is a relevant factor for the development of the metabolic syndrome in mice. PloS One 9(8):e105349
  12.Kitahara CM, Neta G, Pfeiffer RM, Kwon D, Xu L, Freedman ND, Hutchinson AA, Chanock SJ, Sturgis EM, Sigurdson AJ, Brenner AV (2012) Common obesity-related genetic variants and papillary thyroid cancer risk. Cancer Epidemiol Biomark Prev 21(12):2268–2271CrossRef
  13.Tang H, Dong X, Hassan M, Abbruzzese JL, Li D (2011) Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. Cancer Epidemiol Biomark Prev 20(5):779–792CrossRef
  14.Pierce BL, Austin MA, Ahsan H (2011) Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data. Cancer Causes Control 22(6):877–883PubMed CrossRef
  15.Li G, Chen Q, Wang L, Ke D, Yuan Z (2012) Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31,153 controls. Tumor Biol 33(4):1–7
  16.Iles MM, Law MH, Stacey SN, Han J, Fang S, Pfeiffer R, Harland M, MacGregor S, Taylor JC, Aben KK, Akslen LA, Avril MF, Azizi E, Bakker B, Benediktsdottir KR, Bergman W, Scarra GB, Brown KM, Calista D, Chaudru V, Fargnoli MC, Cust AE, Demenais F, De Waal AC, Debniak T, Elder DE, Friedman E, Galan P, Ghiorzo P, Gillanders EM, Goldstein AM, Gruis NA, Hansson J, Helsing P, Hocevar M, Hoiom V, Hopper JL, Ingvar C, Janssen M, Jenkins MA, Kanetsky PA, Kiemeney LA, Lang J, Lathrop GM, Leachman S, Lee JE, Lubinski J, MacKie RM, Mann GJ, Martin NG, Mayordomo JI, Molven A, Mulder S, Nagore E, Novakovic S, Okamoto I, Olafsson JH, Olsson H, Pehamberger H, Peris K, Grasa MP, Planelles D, Puig S, Puig-Butille JA, Randerson-Moor J, Requena C, Rivoltini L, Rodolfo M, Santinami M, Sigurgeirsson B, Snowden H, Song F, Sulem P, Thorisdottir K, Tuominen R, Van Belle P, Van Der Stoep N, Van Rossum MM, Wei Q, Wendt J, Zelenika D, Zhang M, Landi MT, Thorleifsson G, Bishop DT, Amos CI, Hayward NK, Stefansson K, Bishop JAN, Barrett JH (2013) A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet 45(4):428–432PubMed PubMedCentral CrossRef
  17.Hernandez-Caballero ME, Sierra-Ramirez JA (2014) Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview. Mol Biol Rep. doi:10.​1007/​s11033-014-3817-y PubMed
  18.Delahanty RJ, Beeghly-Fadiel A, Xiang YB, Long J, Cai Q, Wen W, Xu WH, Cai H, He J, Gao YT, Zheng W, Shu XO (2011) Association of obesity-related genetic variants with endometrial cancer risk: a report from the shanghai endometrial cancer genetics study. Am J Epidemiol 174(10):1115–1126PubMed PubMedCentral CrossRef
  19.Meyer TE, Boerwinkle E, Morrison AC, Volcik KA, Sanderson M, Coker AL, Pankow JS, Folsom AR (2010) Diabetes genes and prostate cancer in the atherosclerosis risk in communities study. Cancer Epidemiol Biomark Prev 19(2):558–565CrossRef
  20.Gaudet MM, Yang HP, Bosquet JG, Healey CS, Ahmed S, Dunning AM, Easton DF, Spurdle AB, Ferguson K, O’Mara T, Lambrechts D, Despierre E, Vergote I, Amant F, Lacey JV Jr, Lissowska J, Peplonska B, Brinton LA, Chanock S, Garcia-Closas M (2010) No association between FTO or HHEX and endometrial cancer risk. Cancer Epidemiol Biomark Prevent 19(8):2106–2109. doi:10.​1158/​1055-9965.​epi-10-0515 CrossRef
  21.Lim U, Wilkens LR, Monroe KR, Caberto C, Tiirikainen M, Cheng I, Park SL, Stram DO, Henderson BE, Kolonel LN, Haiman CA, Le Marchand L (2012) Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies. Int J Cancer 131(6):E1038–E1043PubMed PubMedCentral CrossRef
  22.Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101PubMed CrossRef
  23.Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Fernando C (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement: executive Summary. Crit Pathw Cardiol 4(4):198–203PubMed CrossRef
  24.Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O’Rahilly S, Schofield CJ (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318(5855):1469–1472. doi:10.​1126/​science.​1151710 PubMed PubMedCentral CrossRef
  25.Qian Y, Liu S, Lu F, Li H, Dong M, Lin Y, Du J, Gong J, Jin G, Dai J, Hu Z, Shen H (2013) Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese. BMC Genet 14:86. doi:10.​1186/​1471-2156-14-86 PubMed PubMedCentral CrossRef
  26.Jowett JB, Curran JE, Johnson MP, Carless MA, Goring HH, Dyer TD, Cole SA, Comuzzie AG, MacCluer JW, Moses EK, Blangero J (2010) Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes 59(3):726–732. doi:10.​2337/​db09-1277 PubMed PubMedCentral CrossRef
  27.Ma J, Huang M, Wang L, Ye W, Tong Y, Wang H (2015) Obesity and risk of thyroid cancer: evidence from a meta-analysis of 21 observational studies. Med Sci Monitor 21:283–291. doi:10.​12659/​msm.​892035 CrossRef
  28.Conway DI, Brenner DR, McMahon AD, Macpherson LM, Agudo A, Ahrens W, Bosetti C, Brenner H, Castellsague X, Chen C, Curado MP, Curioni OA, Dal Maso L, Daudt AW, de Gois Filho JF, D'Souza G, Edefonti V, Fabianova E, Fernandez L, Franceschi S, Gillison M, Hayes RB, Healy CM, Herrero R, Holcatova I, Jayaprakash V, Kelsey K, Kjaerheim K, Koifman S, La Vecchia C, Lagiou P, Lazarus P, Levi F, Lissowska J, Luce D, Macfarlane TV, Mates D, Matos E, McClean M, Menezes AM, Menvielle G, Merletti F, Morgenstern H, Moysich K, Muller H, Muscat J, Olshan AF, Purdue MP, Ramroth H, Richiardi L, Rudnai P, Schantz S, Schwartz SM, Shangina O, Simonato L, Smith E, Stucker I, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Thomson P, Vaughan TL, Wei Q, Winn DM, Wunsch-Filho V, Yu GP, Zhang ZF, Zheng T, Znaor A, Boffetta P, Chuang SC, Ghodrat M, Amy Lee YC, Hashibe M, Brennan P (2015) Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries. Int J Cancer 136(5):1125–1139. doi:10.​1002/​ijc.​29063
  
• 作者单位：Jian Zhao (1)
  Xiaoyi Huang (2)
  Mingyuan Yang (1)
  Ming Li (1)
  Jianming Zheng (2)
  
  1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200438, People’s Republic of China
  2. Department of Pathology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200438, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Human Genetics
  Epidemiology
  
• 出版者：Springer Netherlands
• ISSN：1573-7292

文摘

A meta-analysis on cancer risk relevant to FTOrs8050136 polymorphism. To investigate the comprehensive effect of FTOrs8050136 polymorphism on cancer risk based on a pooled result. Carcinogenesis is closely related to obesity. Both obesity and cancer share common pathogenic factors such as hereditary susceptibility and environmental predisposition. Recently, several studies had reported that the FTOrs8050136 polymorphism, a genetic variation highly associated with obesity, can be a potential cancer risk factor, while these results were inconsistent. With the help of PubMed, EMBASE, Chinese National Knowledge Infrastructure considerable research was done for potential studies without language restriction. Pooled odds ratio combined with 95 % confidence interval was employed to evaluate the potential correlations, and subgroup analyses were performed based on the cancer types and ethnic populations. There were eight articles comprising 21,810 cases and 85,070 controls met the eligibility criteria. Overall, there was no significant association between the FTOrs8050136 polymorphism and cancer risk (P = 0.163). Subgroup analysis illustrated that no association existed between the FTOrs8050136 polymorphism and cancer risk in Caucasians (P = 0.809), Asians (P = 0.412) and the mixed population (P = 0.093). With regard to cancer types, the result suggested that the FTOrs8050136 polymorphism had no connection with pancreatic cancer (P = 0.089), endometrial cancer (P = 0.353), prostate cancer (P = 0.578), colorectal cancer (P = 0.054) and melanoma (P = 0.357), while the inverse result was obtained in the subgroup of papillary thyroid cancer (P = 0.010). The FTOrs8050136 polymorphism may be not associated with carcinogenesis apart from papillary thyroid cancer, and further studies are needed to investigate the potential correlation. Keywords FTO Polymorphism Cancer rs8050136 Meta-analysis IVSA1-27777C>A