Japanese encephalitis accompanied by cerebral venous sinus thrombosis: a case report

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• 作者：Min Jia (1) (2)
  Nian Xiong (1)
  Jinsha Huang (1)
  Youpei Wang (1)
  Xiaowei Zhang (1)
  Zhentao Zhang (3)
  Xuebing Cao (1)
  Zhicheng Lin (4) (5)
  Tao Wang (1)
  
• 关键词：Cerebral venous sinus thrombosis ; Epidemic encephalitis type B ; Magnetic resonance venography ; Encephalitis type B ; specific IgM antibody ; Case report
• 刊名：BMC Neurology
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：12
• 期：1
• 全文大小：240KB
• 参考文献：1. Wang H, Li Y, Liang X, Liang G: Japanese encephalitis in mainland china. / Jpn J Infect Dis 2009,62(5):331鈥?36.
  2. Bousser MG, Ferro JM: Cerebral venous thrombosis: an update. / Lancet Neurol 2007,6(2):162鈥?70. CrossRef
  3. Kashyap AS, Anand KP, Kashyap S: Thrombosis of the cerebral veins and sinuses. / N Engl J Med 2005,353(3):314鈥?15. CrossRef
  4. Stam J: Thrombosis of the cerebral veins and sinuses. / N Engl J Med 2005,352(17):1791鈥?798. CrossRef
  5. Prakash M, Kumar S, Gupta RK: Diffusion-weighted MR imaging in Japanese encephalitis. / J Comput Assist Tomogr 2004,28(6):756鈥?61. CrossRef
  6. Bousser MG: Cerebral venous thrombosis: diagnosis and management. / J Neurol 2000,247(4):252鈥?58. CrossRef
  7. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/12/43/prepub
  
• 作者单位：Min Jia (1) (2)
  Nian Xiong (1)
  Jinsha Huang (1)
  Youpei Wang (1)
  Xiaowei Zhang (1)
  Zhentao Zhang (3)
  Xuebing Cao (1)
  Zhicheng Lin (4) (5)
  Tao Wang (1)
  
  1. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, Hubei, China
  2. Department of Neurology, The Central Hospital in En Shi, 158 Wu Yang Ave, 445000, En Shi, Hubei, China
  3. Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China
  4. Department of Psychiatry, Harvard Medical School; Division of Alcohol and Drug Abuse, and Mailman Neuroscience Research Center, McLean Hospital, Belmont, MA, 02478, USA
  5. Harvard NeuroDiscovery Center, Boston, MA, 02114, USA
  

文摘

Background Cerebral venous sinus thrombosis (CVST) is a relatively rare cerebrovascular condition which accounts for 0.5% of all strokes. Risk of CVST has been documented in patients with numerous conditions including central nervous system infections, however, Japanese encephalitis (JE, epidemic encephalitis type B) with CVST has not been reported previously. Case Presentation Here, we present a case of JE with CVST in a 17-year-old man. On admission, the patient was initially diagnosed as intracranial infection, and soon after, brain magnetic resonance (MR) imaging (MRI) and MR Venography (MRV) confirmed the diagnosis of CVST. Moreover, the blood JE-specific IgM antibody which proved weakly positive at first, turned positive one week later. Consequently, our patient was diagnosed as CVST accompanied by JE. Anticoagulant and anti-infective therapy were initiated, which eventually lead to gradual recovery of the patient. Conclusions To our knowledge, this is the first case report of CVST associated with JE. MRI and MRV represent a prime method for the diagnosis of CVST, while the positivity of JE virus IgM antibody, especially increased antibody levels within a short period, is of great significance to diagnose JE. The early diagnosis and timely treatment of this potentially lethal condition would improve its prognosis significantly.