Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation
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- 作者：WenTao Yue (1)
XiaoTing Zhao (1)
LiNa Zhang (1)
ZhiDong Liu (2)
Li Ma (1)
WenYun Jia (1)
Zhe Qian (1)
ChunYan Zhang (1)
Yue Wang (1)
XueHui Yang (1)
ShaoFa Xu (2) - 关键词：CCNY ; NSCLC ; lentivirus RNAi ; H1299
- 刊名：Science China Life Sciences
- 出版年：2010
- 出版时间：April 2010
- 年：2010
- 卷：53
- 期：4
- 页码：511-516
- 全文大小：1228KB
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XiaoTing Zhao (1)
LiNa Zhang (1)
ZhiDong Liu (2)
Li Ma (1)
WenYun Jia (1)
Zhe Qian (1)
ChunYan Zhang (1)
Yue Wang (1)
XueHui Yang (1)
ShaoFa Xu (2)
1. Department of Cellular Biology, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China
2. Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China
文摘
Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.