β-Cyclodextrin polymer brushes decorated magnetic colloidal nanocrystal clusters for the release of hydrophobic drugs
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- 作者：Shaonan Lv (1)
Meiqin Zhao (1)
Changjing Cheng (1)
Zhigang Zhao (1) - 关键词：Magnetic colloidal nanocrystal clusters ; Functionalization ; Polymer brushes ; β ; Cyclodextrin ; SI ; ATRP ; Nanomedicine
- 刊名：Journal of Nanoparticle Research
- 出版年：2014
- 出版时间：May 2014
- 年：2014
- 卷：16
- 期：5
- 全文大小：980 KB
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Meiqin Zhao (1)
Changjing Cheng (1)
Zhigang Zhao (1)
1. College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu, 610041, Sichuan, People’s Republic of China - ISSN：1572-896X
文摘
β-Cyclodextrin (β-CD) polymer brushes decorated magnetic Fe3O4 colloidal nanocrystal clusters (Fe3O4@PG-CD) were fabricated by a combination of surface-initiated atom transfer radical polymerization on the surface of Br-anchored Fe3O4 colloidal nanocrystal clusters (Fe3O4–Br) and ring-opening reaction of epoxy groups. The resulted Fe3O4@PG-CD hybrid nanoparticles were characterized by several methods including Fourier transform infrared, transmission electron microscope, dynamic light scattering instrument, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometer. Moreover, the potential of as-synthesized Fe3O4@PG-CD as a carrier of hydrophobic anticancer drug 5-fluorouracil (5-FU) was also investigated. The results showed that the prepared Fe3O4@PG-CD have core/shell structure and high saturated magnetism. 5-FU could be loaded into the Fe3O4@PG-CD via the formation of β-CD/5-FU inclusion complex. Furthermore, the Fe3O4@PG-CD displayed a high loading capacity and pH-dependent release behavior for 5-FU. The release behavior demonstrated a simple Fickian diffusion in the acidic environment (pH 2.0 and 4.0) but neither non-Fickian nor anomalous when neutral. The results reveal that this nanosystem seems to be a very promising vehicle for the hydrophobic drugs for pH-dependent controlled release.