Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease

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• 作者：Ru Ding (1)
  Wenwu Gao (2)
  David H. Ostrodci (3)
  Zhiqing He (1)
  Yuanlin Song (4)
  Lan Ma (5)
  Chun Liang (1)
  Zonggui Wu (1)
  
• 关键词：Interleukin ; 2 ; serum level ; polymorphism ; coronary artery disease
• 刊名：Inflammation
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：36
• 期：6
• 页码：1225-1231
• 全文大小：
• 作者单位：Ru Ding (1)
  Wenwu Gao (2)
  David H. Ostrodci (3)
  Zhiqing He (1)
  Yuanlin Song (4)
  Lan Ma (5)
  Chun Liang (1)
  Zonggui Wu (1)
  
  1. Department of Cardiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China
  2. Department of Orthopedics, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China
  3. Faculty of Medicine, New York University, New York, NY, 10011, USA
  4. Shandong Academy of Agricultural Sciences, Jinan, Shandong, 250100, China
  5. Department of Cardiology, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai, 200120, China
  
• ISSN：1573-2576

文摘

Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 ?330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 ?330GG genotype was significantly increased in CAD than in controls (p?=?5.1??10?6). Function analysis revealed that subjects carrying IL-2 ?330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p?<?0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p?<?0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p?<?0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.