Effects of CCK-8 and Cystathionine γ-Lyase/Hydrogen Sulfide System on Acute Lung Injury in Rats
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- 作者：Fengjun Tian ; Yiling Ling ; Yuqin Chen ; Zhiyong Wang
- 关键词：KEY WORDSacute lung injury (ALI) ; cholecystokinin ; octapeptide (CCK ; 8) ; lipopolysaccharide (LPS) ; hydrogen sulfide (H2S) ; cystathionine γ ; lyase (CSE)
- 刊名：Inflammation
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：40
- 期：1
- 页码：174-183
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Rheumatology; Internal Medicine; Pharmacology/Toxicology; Pathology;
- 出版者：Springer US
- ISSN：1573-2576
- 卷排序：40
文摘
Acute lung injury (ALI) is mainly characterized by diffusive injuries to lung epithelium and increased permeability of alveolar-capillary membranes caused by various factors, which leads to pulmonary edema and pulmonary closure. Lipopolysaccharide (LPS), which is the main component of the cell wall of gram-negative bacteria, is one of the most important factors causing pulmonary infection and ALI. More and more reports have indicated that hydrogen sulfide (H2S) is closely correlated with ALI and has anti-inflammation function, while the specific mechanism needs further investigation. Cholecystokinin-octapeptide (CCK-8), which is an important endogenous functional fragment belonging to CCK family, participates in anti-inflammatory and anti-endotoxic shock (ES). Whether CCK-8 plays important roles in curing ALI also needs further investigation. Herein, we concluded that CCK-8 alleviated the ALI induced by LPS via regulating the catalytic activity of cystathionine γ-lyase (CSE) and the formation of H2S. This work provides new medicine-designed target for clinical doctor to prevent and cure ALI.