Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations

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• 作者：Zhiyong Huang ; Quan Hong ; Xueguang Zhang ; Wenzhen Xiao…
• 关键词：Aldose reductase ; Endothelial cell dysfunction ; Uric acid ; Reactive oxygen species ; Hyperuricemia ; CKD
• 刊名：Cell Communication and Signaling
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：2014KB
• 刊物主题：Cell Biology; Protein-Ligand Interactions; Receptors; Cytokines and Growth Factors;
• 出版者：BioMed Central
• ISSN：1478-811X
• 卷排序：15

文摘

BackgroundUric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative stress-related complications of diabetes. We sought to determine the mechanism by which UA becomes deleterious at high concentrations as well as the effect of AR in this process.