Core–shell Au@MnO₂ nanoparticles for enhanced radiotherapy via improving the tumor oxygenation

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• 作者：Xuan Yi ; Lei Chen ; Xiaoyan Zhong ; Roulin Gao ; Yitao Qian ; Fan Wu…
• 关键词：enhanced radiotherapy ; radiosensitizer ; hypoxia ; high ; Z element ; core–shell structure
• 刊名：Nano Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：9
• 期：11
• 页码：3267-3278
• 全文大小：3,058 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chinese Library of Science
  Chemistry
  Nanotechnology
  
• 出版者：Tsinghua University Press, co-published with Springer-Verlag GmbH
• ISSN：1998-0000
• 卷排序：9

文摘

Local hypoxia in solid tumors often results in resistance to radiotherapy (RT), in which oxygen is an essential element for enhancing DNA damage caused by ionizing radiation. Herein, we developed gold@manganese dioxide (Au@MnO₂) core–shell nanoparticles with a polyethylene glycol (PEG) coating as a novel radiosensitizing agent to improve RT efficacy during cancer treatment. In this Au@MnO₂ nanostructure, while the gold core is a well-known RT sensitizer that interacts with X-rays to produce charged particles for improved cancer killing under RT, the MnO₂ shell may trigger the decomposition of endogenous H₂O₂ in the tumor microenvironment to generate oxygen and overcome hypoxiaassociated RT resistance. As demonstrated by both in vitro and in vivo experiments, Au@MnO₂-PEG nanoparticles acted as effective radiosensitizers to remarkably enhance cancer treatment efficacy during RT. Moreover, no obvious side effects of Au@MnO₂-PEG were observed in mice. Therefore, our work presents a new type of radiosensitizer with potential for enhanced RT treatment of hypoxic tumors.