Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year
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- 作者：Huiling Guo (1)
Xiu Liu (1)
Chenyang Li (2)
Yushu Li (1)
Miao Sang (1)
Zhongyan Shan (1)
Weiping Teng (1)
Haixia Guan (1) - 关键词：Autoimmune ; Interleukin ; 6 ; Leptin ; Postpartum thyroiditis
- 刊名：Endocrine
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：47
- 期：2
- 页码：512-518
- 全文大小：355 KB
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Xiu Liu (1)
Chenyang Li (2)
Yushu Li (1)
Miao Sang (1)
Zhongyan Shan (1)
Weiping Teng (1)
Haixia Guan (1)
1. Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University; Institute of Endocrinology, The Liaoning Provincial Key Laboratory of Endocrine Diseases, China Medical University, 155 Nanjing Bei Street, Liaoning, Shenyang, 110001, People鈥檚 Republic of China
2. Department of Gynecology and Obstetrics, Shenyang Women鈥檚 and Children鈥檚 Hospital, Shenyang, People鈥檚 Republic of China - ISSN：1559-0100
文摘
The purpose of the study is to explore the roles of leptin and interleukin-6 (IL-6) during the first postpartum year in the occurrence and development of postpartum thyroiditis (PPT). We retrospectively collected serum samples from 57 PPT patients consisting of 34 overt PPT (O-PPT) and 23 subclinical PPT (S-PPT) in addition to 37 healthy postpartum women at four postpartum time points, i.e., 3-day and 3, 6, 12-month postpartum. Serum leptin and IL-6 levels were measured by radioimmunoassay and ELISA assay, respectively. Leptin level and leptin/BMI (LEP/BMI) ratio were higher in PPT patients than in control during the first postpartum year, but were not significantly different between O-PPT and S-PPT. However, a similar trend but did not reach significant difference in IL-6 level was observed during the postpartum period in PPT patients and control women. We conclude that a sustained high level of serum leptin after delivery may be involved in the pathogenesis of PPT. IL-6 does not contribute to the development of PPT.