Clinical significance of CUL4A in human prostate cancer

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• 作者：Gang Liu ; Zengjun Zhu ; Fang Lang ; Bao Li ; Dianjun Gao
• 关键词：Prostate cancer ; CUL4A ; P53 ; Proliferation ; Targeted therapy
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：36
• 期：11
• 页码：8553-8558
• 全文大小：482 KB
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• 作者单位：Gang Liu (1)
  Zengjun Zhu (1)
  Fang Lang (1)
  Bao Li (1)
  Dianjun Gao (1)
  
  1. Department of Urology, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Kuiwei District, Weifang, Shandong, China
  
• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Aberrant expression of the Cullin 4A (CUL4A) is found in many tumor types, but the functions and mechanism of CUL4A in prostate cancer (PCa) development and progression remain largely unknown. The aim of this study was to investigate the possible role of CUL4A in prostate tumorigenesis. Immunohistochemistry was used to examine CUL4A expression in human PCa tissues and BPH tissues. Cell proliferation was assessed by MTT, and migration and invasion were analyzed by Transwell and Matrigel assays after CUL4A knockdown in PCa in vitro. The results showed that CUL4A protein was overexpressed in 86.21 % of PCa tissues. CUL4A knockdown with siRNA in PCa cells decreased cell proliferation, migration, and invasion. Mechanistically, CUL4A could modulate the expression of P53 in PCa cells. Our results indicate that CUL4A overexpression play an oncogenic role in the pathogenesis of PCa, and CUL4A may be a potential therapeutic target for PCa. Keyword Prostate cancer CUL4A P53 Proliferation Targeted therapy