Expression of T-box transcription factors 2, 4 and 5 is decreased in the branching airway mesenchyme of nitrofen-induced hypoplastic lungs
详细信息 查看全文
- 作者：Toshiaki Takahashi ; Florian Friedmacher ; Julia Zimmer…
- 关键词：T ; box transcription factor ; Lung branching ; Pulmonary hypoplasia ; Congenital diaphragmatic hernia ; Nitrofen
- 刊名：Pediatric Surgery International
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：33
- 期：2
- 页码：139-143
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Pediatrics; Surgery; Pediatric Surgery;
- 出版者：Springer Berlin Heidelberg
- ISSN：1437-9813
- 卷排序：33
文摘
PurposePulmonary hypoplasia (PH), characterized by smaller lung size and reduced airway branching, remains a major therapeutic challenge in newborns with congenital diaphragmatic hernia (CDH). T-box transcription factors (Tbx) have been identified as key components of the gene network that regulates fetal lung development. Tbx2, Tbx4 and Tbx5 are expressed throughout the mesenchyme of the developing lung, regulating the process of lung branching morphogenesis. Furthermore, lungs of Tbx2-, Tbx4- and Tbx5-deficient mice are hypoplastic and exhibit decreased lung branching, similar to PH in human CDH. We hypothesized that the expression of Tbx2, Tbx4 and Tbx5 is decreased in the branching airway mesenchyme of hypoplastic rat lungs with nitrofen-induced CDH.