The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese

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• 作者：Xuling Chang ; Hui-Lin Chin ; Swee-Chye Quek ; Daniel Y. T. Goh…
• 关键词：Coagulation factors ; Coronary artery disease ; Androgen ; dependent tissue factor pathway inhibitor regulating protein ; Genetic variant
• 刊名：Thrombosis Journal
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：393KB
• 刊物主题：Angiology; Cardiology; Hematology;
• 出版者：BioMed Central
• ISSN：1477-9560
• 卷排序：15

文摘

BackgroundGenome-wide association study (GWAS) has reported that rs6903956 within the first intron of androgen-dependent tissue factor pathway inhibitor (TFPI) regulating protein (ADTRP) gene is associated with coronary artery disease (CAD) risk in the Chinese population. Although ADTRP is believed to be involved in the upregulation of TFPI, the underlying mechanism involved is largely unknown. This study investigated the association of rs6903956 with plasma Factor VII coagulant activity (FVIIc) and fibrinogen levels, which are regulated by TFPI and are independent risk predictors for CAD.