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Correlation between serum CA724 and gastric cancer: multiple analyses based on Chinese population
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  • 作者：Xin-Zu Chen (1)
    Wei-Ke Zhang (2)
    Kun Yang (1)
    Lan-Lan Wang (3)
    Jin Liu (3)
    Li Wang (4)
    Jian-Kun Hu (1) hujkwch@126.com
    Bo Zhang (1) zhangbo7310@126.com
    Zhi-Xin Chen (1)
    Jia-Ping Chen (1)
    Zong-Guang Zhou (1)
    Xian-Ming Mo (5)
  • 关键词：Gastric cancer – ; CA724 – ; CEA – ; CA199 – ; Tumor biomarker – ; Meta ; analysis – ; Summary ROC – ; Chinese
  • 刊名：Molecular Biology Reports
  • 出版年：2012
  • 出版时间：September 2012
  • 年：2012
  • 卷：39
  • 期：9
  • 页码：9031-9039
  • 全文大小：524.9 KB
  • 参考文献：1. Kamangar F, Dores GM, Anderson WF (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24(14):2137–2150
    2. Crew KD, Neugut AI (2006) Epidemiology of gastric cancer. World J Gastroenterol 12(3):354–362
    3. National Comprehensive Cancer Network (2010) Clinical practice guidelines in oncology: gastric cancer. http://www.nccn.org/professionals/physician_gls/PDF/gastric.pdf. Accessed 14 August 2010
    4. Jeung HC, Rha SY, Noh SH et al (2001) Adjuvant 5-fluorouracil plus doxorubicin in D2–3 resected gastric carcinoma: 15-year experience at a single institute. Cancer 91(11):2016–2025
    5. Yang L, Parkin DM, Ferlay J et al (2005) Estimates of cancer incidence in China for 2000 and projections for 2005. Cancer Epidemiol Biomarkers Prev 14(1):243–250
    6. Chen XZ, Jiang K, Hu JK et al (2008) Cost-effectiveness analysis of chemotherapy for advanced gastric cancer in China. World J Gastroenterol 14(17):2715–2722
    7. Duraker N, Celik AN (2001) The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: comparison with CEA. J Surg Oncol 76(4):266–271
    8. Louhimo J, Kokkola A, Alfthan H et al (2004) Preoperative hCGbeta and CA 72-4 are prognostic factors in gastric cancer. Int J Cancer 111(6):929–933
    9. Gaspar MJ, Arribas I, Coca MC et al (2001) Prognostic value of carcinoembryonic antigen, CA 19-9 and CA 72-4 in gastric carcinoma. Tumour Biol 22(5):318–322
    10. Higgins JPT, Green S (eds) (2008) Cochrane handbook for systematic reviews of interventions version 5.0.0. The Cochrane Collaboration. http://www.cochrane.org/resources/handbook.Accessed February 2008
    11. Littenberg B, Moses LE (1993) Estimating diagnostic accuracy from multiple conflicting reports: a new analytic method. Med Decis Making 13(4):313–321
    12. Huang LS, Lao M, Shen J et al (2005) The value of combined detection of GPDA, CA72-4 and CA50 in diagnosis of gastric cancer. Cancer Res Prev Treat 32(9):560–561 (in Chinese)
    13. Ji XP, Zheng YS, Gao SS (2003) Diagnostic value of combined detection of CA72-4 and CEA for gastric cancer. J Radioimmunol 16(6):354–355 (in Chinese)
    14. Jiang LL, Yang ZH (2006) Clinical evaluation of serum tumor markers for gastric cancer. Sichuan J Cancer Control 19(3):200–201 (in Chinese)
    15. Li SH, Wang ZZ, Cai JC et al (2006) Clinical significance of combined assay of adrenomedullin, CEA and CA72-4 for diagnosis of gastric cancer. Label Immunoass Clin Med 13(3):175–183 (in Chinese)
    16. Liao QL, Wu KW (2006) Detection of serum CA72-4, CA19-9, CA50 and their clinical value before or after surgery of gastric cancer. China J Mod Med 16(14):2180–2183 (in Chinese)
    17. Liu Y, Li JG (2007) Clinical value of multi-tumor markers detection with (CEA, CA19-9, CA72-4) for diagnosis of gastric malignancy. J Radioimmunol 20(1):16–18 (in Chinese)
    18. Luo WJ, Wu WT, Zeng XQ (2006) The diagnostic value of combined determination of serumCA199 and CA72-4 in the patients with gastric cancer. West China Med J 21(3):519 (in Chinese)
    19. Lv XX, Liu B, Zhang RL (2007) Clinical value of combined detection of serum CEA, CA199 and CA724 in patient with gastric cancer. Chin J Clin Oncol Rehabil 14(1):26–28 (in Chinese)
    20. Niu XW, Sheng WZ, Qin XY (1999) Analysis of CEA, CA19-9, CA72-4 and helicobacter pylori antibodies in patients with gastric cancer. Chin J Bases Clin Gen Surg 6(3):162–165 (in Chinese)
    21. Ren SQ, Niu FH, Cui JJ et al (2006) Combination assay of CA72-4, CA19-9 and CEA in diagnosis of gastric cancer. Henan J Surg 12(6):11 (in Chinese)
    22. Song WH, Liu Y, Jiao XC (2006) Diagnosis value of serum PG-I, CA72-4 and MG7Ag in gastric carcinoma. Chin J Postgrad Med 29(7):34–36 (in Chinese)
    23. Sun XJ, Zhang Q (2006) The expression of serum CEA and CA72-4 combination assay in patients with gastric cancer. Med Lab Sci Clin 17(5):81 (in Chinese)
    24. Wang XP, Zhang TZ (2001) Diagnostic value of combined detection of CA72-4, CA50 and CA19-9 for gastric cancer. Pract J Cancer 16(6):651–652 (in Chinese)
    25. Wang Y (2006) Correlation between levels of serum CA724, CA242 and CEA and stages of gastric cancer. J Radioimmunol 19(3):225–226 (in Chinese)
    26. Wang YL, Yao XH, Lou GC (2006) Clinical evaluation of five tumor markers in peripheral blood from patients with gastric cancer. J Hangzhou Med Coll 26(4):242–4247 (in Chinese)
    27. Xu YC, Chen QA, Sun M (2007) Diagnostic value of combined assay of serum CEA, CA199, CA724 and EMA for gastric cancer. J Radioimmunol 20(3):285–286 (in Chinese)
    28. Yang L, Huang B, Lu AG et al (2007) Clinical evaluation of tumor markers MG-7, CEA, CA19-9 and CA72-4 in the diagnosis and the prognostic judgment of gastric carcinoma. J Diagn Concepts Pract 6(1):43–45 (in Chinese)
    29. Zeng XP, Zhan XW, Liu DJ et al (2006) Diagnostic value of levels of CA19-9, CA72-4 and CEA in gastric cancer. Pract Clin Med 7(10):8–11 (in Chinese)
    30. Zhao JW, Chen M, Hu Y et al (2006) Diagnostic value of combined detection of four tumor markers for gastric cancer. Label Immunoass Clin Med 13(4):196–197 (in Chinese)
    31. Chen YG, Ye J (2001) Evaluation of SIMA, CEA, CA50 and CA19-9 in 56 cases of advanced gastric carcinoma. J Taizhou Polytech Inst 1(4):22,34–5. (in Chinese)
    32. Miao L, Zhang WX, Liu Z et al (2002) Diagnostic value of combined determination of serum CA19-9 and CA125 and CEA in gastric carcinoma. Mod J Integr Tradit Chin West Med 11(23):2315–2316 (in Chinese)
    33. Gu Y, Duan W, Wu XH et al (2006) Combined detection of AFP, CEA, CA19-9 and CA125 in diagnosing malignant tumors of digestive system. J Fourth Mil Med Univ 27(6):518–520 (in Chinese)
    34. Shao JG, Ni RZ (1999) Diagnostic value of serum CA19-9 detection for malignant tumors of digestive system. Acta Acad Med Nantong 19(2):170–171 (in Chinese)
    35. Chen WZ, Dong L (2007) Diagnostic value of combined tumor markers detection for gastric and colorectal cancers. J Radioimmunol 20(3):220–221 (in Chinese)
    36. Liang Z, Wang HF, Wu AZ et al (2005) Clinical value of 12 tumor markers protein biochip in detection of digestive system neoplasm. China Trop Med 5(3):407–409 (in Chinese)
    37. Lu ZY, Huang HD, Li YM (2001) Clinical value of serum CEA, CAl9-9 and CA125 measurement in gastric cancer. Hebei Med 7(6):483–486 (in Chinese)
    38. Sun X, Chen ZD, Gong H (2004) Detection of 12 tumor markers in 617 cases of malignant tumor. Acta Univ Med Anhui 39(5):396–398 (in Chinese)
    39. Sun YP, Shen H (2004) Evaluation of protein-chip system for tumor markers in diagnosis and disease progress of gastric cancer. Chin J Cancer Prev Treat 11(7):703–5 (in Chinese)
    40. Wang HZ, Zhao YT, Zhao GQ et al (2004) Combined assay of serum CA19-9 and CA242 in gastric cancer. Chin Gen Surg 13(9):711–712 (in Chinese)
    41. Wang J, Zhu YQ, Yang SX et al (2000) Clinical evaluation of combined serum tumor markers (CA242 and CEA) in the diagnosis of gastrointestinal malignant tumor. J Capital Univ Med Sci 21(4):292–294 (in Chinese)
    42. Wang Y, Wang XP, Li YR (2005) Value of tumor marker detection in gastric cancer. Sichuan Med 26(9):1020–1021 (in Chinese)
    43. Yu JY (2006) The clinical value of multi-tumor markers protein chip assistance diagnostic system in the diagnosis of gastric cancer. J Chin Physician 8(3):317–319 (in Chinese)
    44. Zuo Q, Li AM, Miao JX et al (2004) Diagnostic value of multi-tumor markers protein biochip detective system for digestive tract cancer. Chin J Clin Oncol 31(6):337–339 (in Chinese)
    45. Chen XZ, Hu JK, Zhou ZG et al (2010) Meta-analysis of effectiveness and safety of D2 plus para-aortic lymphadenectomy for resectable gastric cancer. J Am Coll Surg 210(1):100–105
    46. Chen XZ, Hu JK, Yang K et al (2009) Short-term evaluation of laparoscopy-assisted distal gastrectomy for predictive early gastric cancer: a meta-analysis of randomized controlled trials. Surg Laparosc Endosc Percutan Tech 19(4):277–284
    47. Seregni E, Ferrari L, Martinetti A et al (2001) Diagnostic and prognostic tumor markers in the gastrointestinal tract. Semin Surg Oncol 20(2):147–166
    48. Chen XZ, Yang K, Zhang B et al (2011) Is retrieval of >25 lymph nodes a superior criterion for locally advanced gastric cancer surgery? Ann Surg 254(5):834–835
    49. Chen XZ, Yang K, Liu J et al (2011) Neoadjuvant plus adjuvant chemotherapy benefits overall survival of locally advanced gastric cancer. World J Gastroenterol 17(40):4542–4544
    50. Guadagni F, Roselli M, Amato T et al (1992) CA 72-4 measurement of tumor-associated glycoprotein 72 (TAG-72) as a serum marker in the management of gastric carcinoma. Cancer Res 52(5):1222–1227
    51. Carpelan-Holmstr枚m M, Louhimo J, Stenman UH et al (2002) CEA, CA 19-9 and CA 72-4 improve the diagnostic accuracy in gastrointestinal cancers. Anticancer Res 22(4):2311–2316
    52. Reiter W, Stieber P, Reuter C et al (1997) Prognostic value of preoperative serum levels of CEA, CA 19-9 and CA 72-4 in gastric carcinoma. Anticancer Res 17(4B):2903–2906
    53. Tocchi A, Costa G, Lepre L et al (1998) The role of serum and gastric juice levels of carcinoembryonic antigen, CA19.9 and CA72.4 in patients with gastric cancer. J Cancer Res Clin Oncol 124(8):450–455
    54. Lai IR, Lee WJ, Huang MT et al (2002) Comparison of serum CA72-4, CEA, TPA, CA19-9 and CA125 levels in gastric cancer patients and correlation with recurrence. Hepatogastroenterology 49(46):1157–1160
    55. Marrelli D, Roviello F, De Stefano A et al (1999) Prognostic significance of CEA, CA 19-9 and CA 72-4 preoperative serum levels in gastric carcinoma. Oncology 57(1):55–62
    56. Jackson C, Cunningham D, Oliveira J et al (2009) Gastric cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 20(Suppl 4):34–36
  • 作者单位：1. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Guo Xue Xiang, No. 37, Chengdu, 610041 Sichuan, China2. Faculty of Medical Technology, West China Medical School, Sichuan University, Chengdu, China3. Laboratory of Clinical Immunology, West China Hospital, Sichuan University, Chengdu, China4. Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, China5. Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
  • ISSN：1573-4978
文摘
Serum tumor biomarker carbohydrate antigen 724 (CA724) is noticeable for gastric cancer. Correlation between CA724 and gastric cancer was investigated based on Chinese population. Chinese Biomedical Database, Chinese Journal Full-text Database and PubMed were searched. Gastric cancer patients were proven by biopsy, and control included health volunteers or benign gastric diseases. Participants received at least one test of CA724, CA125, CA153, CA199, CA242 or CEA. Meta-analysis, summary ROC (SROC) and post hoc analysis were performed by RevMan 5.0 and SPSS 11.5. Totally, 33 eligible studies were analyzed. Meta-analysis showed CA724 had the highest odds ratio 32.86 compared to control, orderly followed by CA242, CA199, CEA, CA125 and CA153. Accumulated accuracy rate of CA724 was 77 %, superior to others. In SROC analysis, specificity of all studies was above 0.70, but sensitivity of few studies was above 0.70; CA724 was selected as the preferable single test, followed by CA242, CA199, CEA, CA125 and CA153. If threshold of both specificity and sensitivity up to 0.70, CA153 was unacceptable; if up to 0.80, only CA724 and CA242 were considerable. In CA724-combined patterns, CA724+CEA+CA199 combination performed best by increasing sensitivity to 0.74 without impairing specificity, while CA724 + CA199 pattern was not a proper combination. CA724 was the most correlative serum tumor biomarker for gastric cancer in Chinese population. Sensitivity of serum CA724 is limited, but CA724+CEA+CA199 combination is considerable to improve sensitivity without impairing specificity.

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