Detection of subsequent cervical lymph node metastasis in a patient with gingival carcinoma using computed tomography perfusion with a single-compartment kinetic model

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• 作者：Takafumi Hayashi (1)
  Ray Tanaka (1)
  Manabu Yamazaki (2)
  Jun Cheng (2)
  Yohei Oda (3)
  Harumi Hayashi (4)
  Etsuro Takeishi (5)
  Katsuhiko Honma (5)
  Hideyoshi Nishiyama (1)
  
• 关键词：CT perfusion ; Squamous cell cancer ; Mouth neoplasms ; Lymph nodes
• 刊名：Oral Radiology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：30
• 期：2
• 页码：186-191
• 全文大小：
• 参考文献：1. Trojanowska A, Trojanowski P, Bisdas S, Sta?kiewicz G, Drop A, Klatka J, et al. Squamous cell cancer of hypopharynx and larynx—evaluation of metastatic nodal disease based on computed tomography perfusion studies. Eur J Radiol. 2012;81:1034-. CrossRef
  2. Bisdas S, Medov L, Baghi M, Konstantinou GN, Wagenblast J, Thng CH, et al. A comparison of tumour perfusion assessed by deconvolution-based analysis of dynamic contrast-enhanced CT and MR imaging in patients with squamous cell carcinoma of the upper aerodigestive tract. Eur Radiol. 2008;18:843-0. CrossRef
  3. Sitek A, Sheiman RG. Small-bowel perfusion measurement: feasibility with single-compartment kinetic model applied to dynamic contrast-enhanced CT. Radiology. 2005;237:670-. CrossRef
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  5. Izumo T, Kirita T, Ariji E, Ozeki S, Okada N, Okabe S, et al. General rules for clinical and pathological studies on oral cancer: a synopsis. Jpn J Clin Oncol. 2012;42:1099-09. CrossRef
  6. Bisdas S, Baghi M, Smolarz A, Pihno NC, Lehnert T, Knecht R, et al. Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first-pass contrast-enhanced computed tomography studies. Invest Radiol. 2007;42:172-. CrossRef
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  9. Tawfik AM, Razek AA, Elsorogy LG, Soliman NY, Kerl JM, Mack MG, et al. Perfusion CT of head and neck cancer: effect of arterial input selection. AJR Am J Roentgenol. 2011;196:1374-0. CrossRef
  10. Yamazaki Y, Saitoh M, Notani K, Tei K, Totsuka Y, Takinami S, et al. Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer. Ann Nucl Med. 2008;22:177-4. CrossRef
  11. Vandecaveye V, De Keyzer F, Hermans R. Diffusion-weighted magnetic resonance imaging in neck lymph adenopathy. Cancer Imaging. 2008;8:173-0. CrossRef
  
• 作者单位：Takafumi Hayashi (1)
  Ray Tanaka (1)
  Manabu Yamazaki (2)
  Jun Cheng (2)
  Yohei Oda (3)
  Harumi Hayashi (4)
  Etsuro Takeishi (5)
  Katsuhiko Honma (5)
  Hideyoshi Nishiyama (1)
  
  1. Division of Oral and Maxillofacial Radiology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan
  2. Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan
  3. Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan
  4. Niigata University Gender Equality Office, 2-8050 Ikarashi, Nishi-ku, Niigata, 950-2181, Japan
  5. Department of Oral and Maxillofacial Surgery, Tsuruoka Municipal Shonai Hospital, 4-20 Izumi-machi, Tsuruoka-shi, Yamagata, 997-8515, Japan
  
• ISSN：1613-9674

文摘

We present a preliminary case report on the application of computed tomography perfusion (CTP) with a single-compartment kinetic model for early detection of subsequent lymph node metastasis in gingival carcinoma. A 47-year-old female patient with squamous cell carcinoma of the right lower molar gingiva (cT1N0M0) was reviewed. At 4?months after the initial treatment, a subsequent lymph node metastasis was suspected on monthly follow-up ultrasonography. She provided written informed consent prior to participating in the study, which had been approved by the institutional review board at our institution. After a standard head and neck contrast-enhanced CT examination, CTP images were acquired with a coverage of 32?mm (64?×?0.5-mm thickness) and a total acquisition time of 45?s, initiated at 5?s after intravenous infusion of 40?ml of 370?mg?I/ml non-ionic iodine contrast agent at a rate of 4?ml/s. Post-processing of the CTP data was performed with dedicated software based on a single-compartment kinetic model (Ziosoft Inc., Tokyo, Japan). The SC flow parameter represented the blood flow per unit volume of tissue, in milliliters per minute per milliliter (i.e., min?). The mean SC flow value was 1.144?min? in a totally replaced metastatic node and 0.985?min? in a partially replaced node, compared with 0.787?min? in the contralateral benign node. In conclusion, CTP with a single-compartment kinetic model is considered to be one of the useful methods for detection of a small non-necrotic subsequently developing metastatic cervical lymph node.