Expression of natriuretic peptide receptor-A in esophageal squamous cell carcinomas and the relationship with tumor invasion and migration

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• 作者：Zhilong Zhao (1) (2)
  Haoqian Liu (2)
  Ya Yang (1)
  Kai Sun (1)
  Min Li (1)
  Jia Zhang (1)
  Hui Cai (1)
  Jiansheng Wang (1)
  
  1. Department of second Thoracic surgery ; First Affiliated Hospital ; Xi鈥檃n Jiaotong University ; Yanta West Road no. 277 ; Xi鈥檃n ; Shaanxi ; 710061 ; China
  2. Department of Surgical Oncology ; Baoji Central hospital ; Jiang Tan Road no. 8 ; Baoji ; Shaanxi ; 721000 ; China
  
• 关键词：natriuretic peptide receptor ; A ; NPRA ; esophageal squamous cell carcinoma ; ESCC ; MMP ; invasion ; migration
• 刊名：World Journal of Surgical Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：546 KB
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• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Background The natriuretic peptide receptor-A (NPRA) has been investigated as a receptor of natriuretic peptides in the cardiovascular system. In this study, however, we analyze the expression status of NPRA and the relationship with tumor invasion in esophageal squamous cell carcinoma (ESCC) for the first time. Methods Western blots were used to examine the expression status of protein in human ESCC cell lines. Then, we used immunohistochemistry to detect the expression of NPRA in 45 ESCC specimens and 40 corresponding nontumor tissues. The clinical data were analyzed through statistical methods. Sh-RNA-NPRA was transfected into Eca109 cells to detect the relationship between NPRA and cell invasion through transwell assays. Results In esophageal squamous cells, the expression of NPRA was strongly detected in the cytoplasm, while undetectable or very weak in the nucleus. The positive rates of NPRA in cancer tissues are significantly higher than that in nontumor tissues (P P in vitro and may be involved in MMP2 and MMP9 activation. Conclusions NPRA protein is highly expressed in ESCC tissues and could promote Eca109 cell migration and invasion in vitro.