The action of CGRP and SP on cultured skin fibroblasts

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• 作者：Bernardo Hochman (1)
  Vanina M. Tucci-Viegas (1) (2)
  Paola K. P. Monteiro (1)
  Jer?nimo P. Fran?a (3)
  Silvana Gaiba (1) (3)
  Lydia M. Ferreira (1)
  
• 关键词：Calcitonin gene ; related peptide ; Substance P ; Fibroblasts ; Wound healing ; Skin
• 刊名：Central European Journal of Biology
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：9
• 期：7
• 页码：717-726
• 全文大小：
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• 作者单位：Bernardo Hochman (1)
  Vanina M. Tucci-Viegas (1) (2)
  Paola K. P. Monteiro (1)
  Jer?nimo P. Fran?a (3)
  Silvana Gaiba (1) (3)
  Lydia M. Ferreira (1)
  
  1. Plastic Surgery Division, Department of Surgery, Postgraduate Program in Translational Surgery, Universidade Federal de S?o Paulo (Unifesp), 04024-002, S?o Paulo/SP, Brazil
  2. Department of Agricultural and Environmental Sciences, Universidade Estadual de Santa Cruz (UESC), 45662-900, Ilhéus/BA, Brazil
  3. Department of Biological Sciences, Universidade Estadual de Santa Cruz (UESC), 45662-900, Ilhéus/BA, Brazil
  
• ISSN：1644-3632

文摘

Background/purpose Calcitonin gene-related peptide (CGRP) is the most abundant neuropeptide in the skin, followed by substance P (SP), vasoactive intestinal peptide (VIP), and other neuropeptides in smaller amounts. The proliferative effect of neuropeptides on fibroblasts may affect wound healing and may be associated with hyperproliferative skin and mesenchymal disorders. Understanding the neuropeptidergic action on fibroblasts may provide relevant information to a deeper comprehension of the healing process. This study reviews the action of the main neuropeptides, CGRP and SP, on cultured human skin fibroblasts. Methods A systematic literature search was conducted on Medline and Web of Science databases on December 21, 2013. Results A total of 74 articles were retrieved using the proposed search strategies and 3 were found in the references section of the selected articles. Thirteen of the retrieved articles studied the action of CGRP and SP on cultured human skin fibroblasts, 12 of which related to SP and 1 related to both CGRP and SP. Conclusion Only one study was retrieved about the action of both CGRP and SP on cultured human skin fibroblasts. Further studies are necessary to investigate CGRP on skin fibroblasts and its role in the fibroplasia phase of wound healing.