Cross feeding of glucose metabolism byproducts of Escherichia coli human gut isolates and probiotic strains affect survival of Vibrio cholerae
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- 作者：Chirantana Sengupta ; Manjula Ekka ; Saurabh Arora ; Prashant D. Dhaware…
- 关键词：V. cholerae survival ; Cocultures ; E. coli Nissle 1917 ; E. coli glucose transport mutants
- 刊名：Gut Pathogens
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：1259KB
- 刊物主题：Gastroenterology; Medical Microbiology; Parasitology;
- 出版者：BioMed Central
- ISSN：1757-4749
- 卷排序：9
文摘
Vibrio cholerae converts glucose into either acid or the neutral end product acetoin and its survival in carbohydrate enriched media is linked to the nature of the byproducts produced. It has been demonstrated in this study that Escherichia coli strain isolated from the gut of healthy human volunteers and the commonly used probiotic E. coli Nissle strain that metabolize glucose to acidic byproducts drastically reduce the survival of V. cholerae strains irrespective of their glucose sensitivity and acetoin production status. Accordingly, E. coli glucose transport mutants that produce lower amounts of acidic metabolites had little effect on the survival of V. cholerae in cocultures. Thus, cross feeding of byproducts of glucose metabolism by heterologous bacteria modulates the survival of V. cholerae in glucose rich medium suggesting that composition of the gut microbiota could influence the outcome of V. cholerae infection especially when glucose based ORS is administered.