Efficacy and safety of once-yearly zoledronic acid in Japanese patients with primary osteoporosis: two-year results from a randomized placebo-controlled double-blind study (ZOledroNate treatment in Efficacy to osteoporosis; ZONE study)

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• 作者：T. Nakamura ; M. Fukunaga ; T. Nakano ; H. Kishimoto ; M. Ito…
• 关键词：Antiresorptives ; Biochemical markers of bone turnover ; Clinical trials ; Fracture prevention ; Osteoporosis
• 刊名：Osteoporosis International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：389-398
• 全文大小：717KB
• 刊物类别：Medicine
• 刊物主题：Orthopedics; Endocrinology; Rheumatology;
• 出版者：Springer London
• ISSN：1433-2965
• 卷排序：28

文摘

SummaryIn a 2-year randomized, placebo-controlled study of 665 Japanese patients with primary osteoporosis, once-yearly administration of zoledronic acid (5 mg) reduced the risk of new morphometric vertebral fractures.