3D Printing of Tissue Engineered Constructs for In Vitro Modeling of Disease Progression and Drug Screening

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• 作者：Joseph Vanderburgh ; Julie A. Sterling…
• 关键词：Additive Manufacturing ; 3D printing ; Bioprinting ; Drug screening ; Tissue engineered constructs
• 刊名：Annals of Biomedical Engineering
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：45
• 期：1
• 页码：164-179
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine, general; Biomedical Engineering; Biological and Medical Physics, Biophysics; Classical Mechanics; Biochemistry, general;
• 出版者：Springer US
• ISSN：1573-9686
• 卷排序：45

文摘

2D cell culture and preclinical animal models have traditionally been implemented for investigating the underlying cellular mechanisms of human disease progression. However, the increasing significance of 3D vs. 2D cell culture has initiated a new era in cell culture research in which 3D in vitro models are emerging as a bridge between traditional 2D cell culture and in vivo animal models. Additive manufacturing (AM, also known as 3D printing), defined as the layer-by-layer fabrication of parts directed by digital information from a 3D computer-aided design file, offers the advantages of simultaneous rapid prototyping and biofunctionalization as well as the precise placement of cells and extracellular matrix with high resolution. In this review, we highlight recent advances in 3D printing of tissue engineered constructs that recapitulate the physical and cellular properties of the tissue microenvironment for investigating mechanisms of disease progression and for screening drugs.