The Early Life Origins of Cardiovascular Disease
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- 作者：Robert Murray (1)
Keith M. Godfrey (1) (2)
Karen A. Lillycrop (3)
1. Faculty of Medicine ; Academic Unit of Human Development and Health ; Southampton ; UK
2. MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre ; University Hospital Southampton NHS Foundation Trust ; University of Southampton ; Southampton ; UK
3. Centre for Biological Sciences ; Faculty of Natural and Environmental Sciences ; Institute of Developmental Sciences ; Southampton General Hospital ; University of Southampton ; Tremona Road ; Southampton ; SO16 6YD ; UK - 关键词：Cardiovascular disease ; Early life origins ; Epigenetic changes ; Epigenetics
- 刊名：Current Cardiovascular Risk Reports
- 出版年：2015
- 出版时间：April 2015
- 年：2015
- 卷：9
- 期：4
- 全文大小：887 KB
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- 出版者：Springer US
- ISSN：1932-9563
文摘
Cardiovascular disease continues to impose a high societal and economic burden. Although it occurs primarily in later life, there is strong evidence that it originates in early life. The nutritional environment that an unborn child is exposed to can heavily influence later disease risk, with nutritional exposures altering organ development and programming metabolic changes that are then maintained during the life course. Epigenetic changes induced by the early life environment are thought to be a key mechanism by which these early life events influence subsequent disease risk. Here, we review the emerging role of epigenetics in the development of cardiovascular disease.