Nuclear imaging for cardiac amyloidosis

详细信息    查看全文

• 作者：Walter Noordzij (1)
  Andor W. J. M. Glaudemans (1)
  Simone Longhi (3) (4)
  Riemer H. J. A. Slart (1)
  Massimiliano Lorenzini (3) (4)
  Bouke P. C. Hazenberg (2)
  Claudio Rapezzi (3) (4)
  
  1. Department of Nuclear Medicine and Molecular Imaging ; University of Groningen ; University Medical Center Groningen ; PO Box 30.001 ; 9700 RB ; Groningen ; The Netherlands
  3. Department of Cardiology ; University of Bologna ; Bologna ; Italy
  4. S. Orsola ; Malpighi Hospital ; Bologna ; Italy
  2. Rheumatology and Clinical Immunology ; University of Groningen ; University Medical Center Groningen ; Groningen ; The Netherlands
  
• 关键词：Amyloidosis ; Nuclear medicine ; PET ; MIBG ; Bone scintigraphy
• 刊名：Heart Failure Reviews
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：20
• 期：2
• 页码：145-154
• 全文大小：535 KB
• 参考文献：1. Hamer, JP, Janssen, S, Rijswijk, MH, Lie, KI (1992) Amyloid cardiomyopathy in systemic non-hereditary amyloidosis. Clinical, echocardiographic and electrocardiographic findings in 30 patients with AA and 24 patients with AL amyloidosis. Eur Heart J 13: pp. 623-627
  2. Hazenberg, BP, Rijswijk, MH, Piers, DA, Lub-de Hooge, MN, Vellenga, E, Haagsma, EB, Hawkins, PN, Jager, PL (2006) Diagnostic performance of 123I-labeled serum amyloid P component scintigraphy in patients with amyloidosis. Am J Med 119: pp. 355.e15-355.e24 CrossRef
  3. Aprile, C, Marinone, G, Saponaro, R, Bonino, C, Merlini, G (1995) Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin. Eur J Nucl Med 22: pp. 1393-1401 CrossRef
  4. Wall, JS, Kennel, SJ, Stuckey, AC, Long, MJ, Townsend, DW, Smith, GT, Wells, KJ, Fu, Y, Stabin, MG, Weiss, DT, Solomon, A (2010) Radioimmunodetection of amyloid deposits in patients with AL amyloidosis. Blood 116: pp. 2241-2244 CrossRef
  5. Rapezzi, C, Quarta, CC, Guidalotti, PL, Longhi, S, Pettinato, C, Leone, O, Ferlini, A, Salvi, F, Gallo, P, Gagliardi, C, Branzi, A (2011) Usefulness and limitations of 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in the aetiological diagnosis of amyloidotic cardiomyopathy. Eur J Nucl Med Mol Imaging 38: pp. 470-478 CrossRef
  6. Antoni, G, Lubberink, M, Estrada, S, Axelsson, J, Carlson, K, Lindsj枚, L, Kero, T, L氓ngstr枚m, B, Granstam, SO, Rosengren, S, Vedin, O, Wassberg, C, Wikstr枚m, G, Westermark, P, S枚rensen, J (2013) In vivo visualization of amyloid deposits in the heart with 11C-PIB and PET. J Nucl Med 54: pp. 213-220 CrossRef
  7. Noordzij, W, Glaudemans, AW, Rheenen, RW, Hazenberg, BP, Tio, RA, Dierckx, RA, Slart, RH (2012) (123)I-Labelled metaiodobenzylguanidine for the evaluation of cardiac sympathetic denervation in early stage amyloidosis. Eur J Nucl Med Mol Imaging 39: pp. 1609-1617 CrossRef
  8. Kula, RW, Engel, WK, Line, BR (1977) Scanning for soft-tissue amyloid. Lancet 1: pp. 92-93 CrossRef
  9. Puille, M, Altland, K, Linke, RP, Steen-M眉ller, MK, Kiett, R, Steiner, D, Bauer, R (2002) 99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy. Eur J Nucl Med Mol Imaging 29: pp. 376-379 CrossRef
  10. Perugini, E, Guidalotti, PL, Salvi, F, Cooke, RM, Pettinato, C, Riva, L, Leone, O, Farsad, M, Ciliberti, P, Bacchi-Reggiani, L, Fallani, F, Branzi, A, Rapezzi, C (2005) Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy. J Am Coll Cardiol 46: pp. 1076-1084 CrossRef
  11. Rapezzi, C, Quarta, CC, Guidalotti, PL, Pettinato, C, Fanti, S, Leone, O, Ferlini, A, Longhi, S, Lorenzini, M, Reggiani, LB, Gagliardi, C, Gallo, P, Villani, C, Salvi, F (2011) Role of (99m)Tc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis. JACC Cardiovasc Imaging 4: pp. 659-670 CrossRef
  12. Longhi, S, Guidalotti, PL, Quarta, CC, Gagliardi, C, Milandri, A, Lorenzini, M, Potena, L, Leone, O, Bartolomei, I, Pastorelli, F, Salvi, F, Rapezzi, C (2014) Identification of TTR-related subclinical amyloidosis with 99mTc-DPD scintigraphy. JACC Cardiovasc Imaging 7: pp. 531-532 CrossRef
  13. Hutt, DF, Quigley, AM, Page, J, Hall, ML, Burniston, M, Gopaul, D, Lane, T, Whelan, CJ, Lachmann, HJ, Gillmore, JD, Hawkins, PN, Wechalekar, AD (2014) Utility and limitations of 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy in systemic amyloidosis. Eur Heart J Cardiovasc Imaging 15: pp. 1289-1298 CrossRef
  14. Fr眉hling, J, Verbist, A, Balikdjian, D (1986) Which diphosphonate for routine bone scintigraphy (MDP, HDP or DPD)?. Nucl Med Commun 7: pp. 415-425 CrossRef
  15. Pauwels, EK, Blom, J, Camps, JA, Hermans, J, Rijke, AM (1983) A comparison between the diagnostic efficacy of 99mTc-MDP, 99mTc-DPD and 99mTc-HDP for the detection of bone metastases. Eur J Nucl Med 8: pp. 118-122 CrossRef
  16. Glaudemans, AW, Rheenen, RW, Berg, MP, Noordzij, W, Koole, M, Blokzijl, H, Dierckx, RA, Slart, RH, Hazenberg, BP (2014) Bone scintigraphy with (99m)technetium-hydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis. Amyloid 21: pp. 35-44 CrossRef
  17. Falk, RH, Lee, VW, Rubinow, A, Hood, WB, Cohen, AS (1983) Sensitivity of technetium-99m-pyrophosphate scintigraphy in diagnosing cardiac amyloidosis. Am J Cardiol 51: pp. 826-830 CrossRef
  18. Lee, VW, Caldarone, AG, Falk, RH, Rubinow, A, Cohen, AS (1983) Amyloidosis of heart and liver: comparison of Tc-99m pyrophosphate and Tc-99m methylene diphosphonate for detection. Radiology 148: pp. 239-242 CrossRef
  19. Eriksson, P, Backman, C, Bjerle, P, Eriksson, A, Holm, S, Olofsson, BO (1984) Non-invasive assessment of the presence and severity of cardiac amyloidosis. A study in familial amyloidosis with polyneuropathy by cross sectional echocardiography and technetium-99m pyrophosphate scintigraphy. Br Heart J 52: pp. 321-326 CrossRef
  20. Janssen, S, Piers, DA, Rijswijk, MH, Meijer, S, Mandema, E (1990) Soft-tissue uptake of 99mTc-diphosphonate and 99mTc-pyrophosphate in amyloidosis. Eur J Nucl Med 16: pp. 663-670 CrossRef
  21. Yamamoto, Y, Onoguchi, M, Haramoto, M, Kodani, N, Komatsu, A, Kitagaki, H, Tanabe, K (2012) Novel method for quantitative evaluation of cardiac amyloidosis using (201)TlCl and (99m)Tc-PYP SPECT. Ann Nucl Med 26: pp. 634-643 CrossRef
  22. Bokhari, S, Casta帽o, A, Pozniakoff, T, Deslisle, S, Latif, F, Maurer, MS (2013) (99m)Tc-pyrophosphate scintigraphy for differentiating light-chain cardiac amyloidosis from the transthyretin-related familial and senile cardiac amyloidoses. Circ Cardiovasc Imaging 6: pp. 195-201 CrossRef
  23. Dorbala S, Vangala D, Semer J, Strader C, Bruyere JR Jr, Di Carli MF, Moore SC, Falk RH (2014) Imaging cardiac amyloidosis: a pilot study using 18F-florbetapir positron emission tomography. Eur J Nucl Med Mol Imaging聽41:1652鈥?662
  24. Furukawa, K, Ikeda, S, Okamura, N, Tashiro, M, Tomita, N, Furumoto, S, Iwata, R, Yanai, K, Kudo, Y, Arai, H (2012) Cardiac positron-emission tomography images with an amyloid-specific tracer in familial transthyretin-related systemic amyloidosis. Circulation 125: pp. 556-557 CrossRef
  25. Glaudemans, AW, Slart, RH, Noordzij, W, Dierckx, RA, Hazenberg, BP (2013) Utility of 18F-FDG PET(/CT) in patients with systemic and localized amyloidosis. Eur J Nucl Med Mol Imaging 40: pp. 1095-1101 CrossRef
  26. Mekinian, A, Jaccard, A, Soussan, M, Launay, D, Berthier, S, Federici, L, Lef猫vre, G, Valeyre, D, Dhote, R, Fain, O (2012) 18F-FDG PET/CT in patients with amyloid light-chain amyloidosis: case-series and literature review. Amyloid 19: pp. 94-98 CrossRef
  27. Nakata, T, Shimamoto, K, Yonekura, S, Sugiyama, T, Imai, K, Iimura, O (1995) Cardiac sympathetic denervation in transthyretin-related familial amyloidotic polyneuropathy: detection with iodine-12-MIBG. J Nucl Med 36: pp. 1040-1042
  28. Tanaka, M, Hongo, M, Kinoshita, O, Takabayashi, Y, Fujii, T, Yazaki, Y, Isobe, M, Sekiguchi, M (1997) Iodine-123 metaiodobenzylguanidine scintigraphic assessment of myocardial sympathetic innervation in patients with familial amyloid polyneuropathy. J Am Coll Cardiol 29: pp. 168-174 CrossRef
  29. Delahaye, N, Dinanian, S, Slama, MS, Mzabi, H, Samuel, D, Adams, D, Merlet, P, Guludec, D (1999) Cardiac sympathetic denervation in familial amyloid polyneuropathy assessed by iodine-123 metaiodobenzylguanidine scintigraphy and heart rate variability. Eur J Nucl Med 26: pp. 416-424 CrossRef
  30. Kline, RC, Swanson, DP, Wieland, DM, Thrall, JH, Gross, MD, Pitt, B, Beierwaltes, WH (1981) Myocardial imaging in man with I-123 metaiodobenzylguanidine. J Nucl Med 22: pp. 129-132
  31. Wieland, DM, Brown, LE, Rogers, WL, Worthington, KC, Wu, JL, Clinthorne, NH, Otto, CA, Swanson, DP, Beierwaltes, WH (1981) Myocardial imaging with a radioiodinated norepinephrine storage analog. J Nucl Med 22: pp. 22-31
  32. Somsen, GA, Verberne, HJ, Fleury, E, Righetti, A (2004) Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies. J Nucl Cardiol 11: pp. 126-133 CrossRef
  33. Ogita, H, Shimonagata, T, Fukunami, M, Kumagai, K, Yamada, T, Asano, Y, Hirata, A, Asai, M, Kusuoka, H, Hori, M, Hoki, N (2001) Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: a prospective study. Heart 86: pp. 656-660 CrossRef
  34. Jacobson, AF, Lombard, J, Banerjee, G, Camici, PG (2009) 123I-mIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: design of two prospective multicenter international trials ADMIRE-HF study. J Nucl Cardiol 16: pp. 113-121 CrossRef
  35. Arbab, AS, Koizumi, K, Toyama, K, Arai, T, Yoshitomi, T, Araki, T (1997) Scan findings of various myocardial SPECT agents in a case of amyloid polyneuropathy with suspected myocardial involvement. Ann Nucl Med 11: pp. 139-141 CrossRef
  36. Delahaye, N, Rouzet, F, Sarda, L, Tamas, C, Dinanian, S, Plante-Bordeneuve, V, Adams, D, Samuel, D, Merlet, P, Syrota, A, Slama, MS, Guludec, D (2006) Impact of liver transplantation on cardiac autonomic denervation in familial amyloid polyneuropathy. Medicine 85: pp. 229-238 CrossRef
  37. Hongo, M, Urushibata, K, Kai, R, Takahashi, W, Koizumi, T, Uchikawa, S, Imamura, H, Kinoshita, O, Owa, M, Fujii, T (2002) Iodine-123 metaiodobenzylguanidine scintigraphic analysis of myocardial sympathetic innervation in patients with AL (primary) amyloidosis. Am Heart J 144: pp. 122-129 CrossRef
  38. Sim玫es, MV, Barthel, P, Matsunari, I, Nekolla, SG, Sch枚mig, A, Schwaiger, M, Schmidt, G, Bengel, FM (2004) Presence of sympathetically denervated but viable myocardium and its electrophysiologic correlates after early revascularised, acute myocardial infarction. Eur Heart J 25: pp. 551-557 CrossRef
  39. Sasano, T, Abraham, R, Chang, KC, Ashikaga, H, Mills, KJ, Holt, DP, Hilton, J, Nekolla, SG, Dong, J, Lardo, AC, Halperin, H, Dannals, RF, Marb谩n, E, Bengel, FM (2008) Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol 51: pp. 2266-2275 CrossRef
  40. Haagsma, EB, Gameren, II, Bijzet, J, Posthumus, MD, Hazenberg, BP (2007) Familial amyloidotic polyneuropathy: long-term follow-up of abdominal fat tissue aspirate in patients with and without liver transplantation. Amyloid 14: pp. 221-226 CrossRef
  41. Coutinho, MC, Cortez-Dias, N, Cantinho, G, Concei莽茫o, I, Oliveira, A, Bordalo e S谩, A, Gon莽alves, S, Almeida, AG, Carvalho, M, Diogo, AN (2013) Reduced myocardial 123-Iodine metaiodobenzylguanidine uptake: a prognostic marker in familial amyloid polyneuropathy. Circ Cardiovasc Imaging 6: pp. 627-636 CrossRef
  42. Dubrey, SW, Cha, K, Anderson, J, Chamarthi, B, Reisinger, J, Skinner, M, Falk, RH (1998) The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement. QJM 91: pp. 141-157 CrossRef
  43. Vrana, JA, Gamez, JD, Madden, BJ, Theis, JD, Bergen, HR, Dogan, A (2009) Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens. Blood 114: pp. 4957-4959 CrossRef
  44. Mueller, PS, Edwards, WD, Gertz, MA (2000) Symptomatic ischemic heart disease resulting from obstructive intramural coronary amyloidosis. Am J Med 109: pp. 181-188 CrossRef
  45. Dorbala, S, Vangala, D, Bruyere, J, Quarta, C, Kruger, J, Padera, R, Foster, C, Hanley, M, Carli, MF, Falk, R (2014) Coronary microvascular dysfunction is related to abnormalities in myocardial structure and function in cardiac amyloidosis. JACC Heart Fail 2: pp. 358-367 CrossRef
  46. Mitra, D, Basu, S (2012) Equilibrium radionuclide angiocardiography: its usefulness in current practice and potential future applications. World J Radiol 4: pp. 421-430 CrossRef
  47. Falk, RH, Rubinow, A, Cohen, AS (1984) Cardiac arrhythmias in systemic amyloidosis: correlation with echocardiographic abnormalities. J Am Coll Cardiol 3: pp. 107-113 CrossRef
  48. Rapezzi, C, Guidalotti, P, Salvi, F, Riva, L, Perugini, E (2008) Usefulness of 99mTc-DPD scintigraphy in cardiac amyloidosis. J Am Coll Cardiol 51: pp. 1509-1510 CrossRef
  49. Karamitsos, TD, Piechnik, SK, Banypersad, SM, Fontana, M, Ntusi, NB, Ferreira, VM, Whelan, CJ, Myerson, SG, Robson, MD, Hawkins, PN, Neubauer, S, Moon, JC (2014) Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging 6: pp. 488-497 CrossRef
  50. Brambilla, F, Lavatelli, F, Silvestre, D, Valentini, V, Palladini, G, Merlini, G, Mauri, P (2013) Shotgun protein profile of human adipose tissue and its changes in relation to systemic amyloidoses. J Proteome Res 12: pp. 5642-5655 CrossRef
  51. Silvestre, D, Brambilla, F, Mauri, PL (2013) Multidimensional protein identification technology for direct-tissue proteomics of heart. Method Mol Biol 1005: pp. 25-38 CrossRef
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  
• 出版者：Springer Netherlands
• ISSN：1573-7322

文摘

Histological analysis of endomyocardial tissue is still the gold standard for the diagnosis of cardiac amyloidosis, but has its limitations. Accordingly, there is a need for non-invasive modalities to diagnose cardiac amyloidosis. Echocardiography and ultrasound and magnetic resonance imaging can show characteristics which may not be very specific for cardiac amyloid. Nuclear medicine has gained a precise role in this context: several imaging modalities have become available for the diagnosis and prognostic stratification of cardiac amyloidosis during the last two decades. The different classes of radiopharmaceuticals have the potential to bind different constituents of the amyloidotic infiltrates, with some relevant differences among the various aetiologic types of amyloidosis and the different organs and tissues involved. This review focuses on the background of the commonly used modalities, their present clinical applications, and future clinical perspectives in imaging patients with (suspected) cardiac amyloidosis. The main focus is on conventional nuclear medicine (bone scintigraphy, cardiac sympathetic innervation) and positron emission tomography.