Acute Toxicity and Environmental Risks of Five Veterinary Pharmaceuticals for Aquatic Macroinvertebrates

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• 作者：Mirco Bundschuh ; Torsten Hahn ; Bert Ehrlich…
• 关键词：Sulfonamide antibiotics ; Benzimidazole anthelmintics ; Ivermectin ; Antiparasitics ; Predicted no effect concentration ; Predicted environmental concentration
• 刊名：Bulletin of Environmental Contamination and Toxicology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：96
• 期：2
• 页码：139-143
• 全文大小：354 KB
• 参考文献：ASTM (1998) Standard guide for acute toxicity test with the rotifer Brachionus E 1440
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• 作者单位：Mirco Bundschuh (1) (2)
  Torsten Hahn (3) (4)
  Bert Ehrlich (1)
  Sibylla Höltge (5)
  Robert Kreuzig (5)
  Ralf Schulz (1)
  
  1. Institute for Environmental Sciences, University Koblenz-Landau, Landau, Germany
  2. Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, Uppsala, Sweden
  3. Fraunhofer Institute for Toxicology and Experimental Medicine, 30625, Hannover, Germany
  4. Zoological Institute, Technical University of Braunschweig, 38092, Braunschweig, Germany
  5. Institute of Environmental and Sustainable Chemistry, Technical University of Braunschweig, 38106, Braunschweig, Germany
  
• 刊物主题：Pollution, general; Environmental Health; Ecotoxicology; Soil Science & Conservation; Environmental Chemistry; Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution;
• 出版者：Springer US
• ISSN：1432-0800

文摘

Due to the high use of antibiotics and antiparasitics for the treatment of livestock, there is concern about the potential impacts of the release of these compounds into freshwater ecosystems. In this context, the present study quantified the acute toxicity of two antibiotics (sulfadiazine and sulfadimidine), and three antiparasitic agents (flubendazole, fenbendazole, ivermectin) for nine freshwater invertebrate species. These experiments revealed a low degree of toxicity for the sulfonamide antibiotics, with limited implications in the survival of all test species at the highest test concentrations (50 and 100 mg/L). In contrast, all three antiparasitic agents indicated on the basis of their acute toxicity risks for the aquatic environment. Moreover, chronic toxicity data from the literature for antiparasitics, including effects on reproduction in daphnids, support the concern about the integrity of aquatic ecosystems posed by releases of these compounds. Thus, these pharmaceuticals warrant further careful consideration by environmental risk managers. Keywords Sulfonamide antibiotics Benzimidazole anthelmintics Ivermectin Antiparasitics Predicted no effect concentration Predicted environmental concentration