Three-dimensional poly-(ε-caprolactone) nanofibrous scaffolds directly promote the cardiomyocyte differentiation of murine-induced pluripotent stem cells through Wnt/β-catenin signaling
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- 作者：Yan Chen ; Di Zeng ; Lu Ding ; Xiao-Li Li ; Xiong-Tao Liu ; Wen-Ju Li…
- 关键词：Poly ; (ε ; caprolactone) ; Nanofibrous scaffold ; Induced pluripotent stem cell ; Cardiomyocyte differentiation
- 刊名：BMC Cell Biology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：3,394 KB
- 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2121
文摘
Background Environmental factors are important for stem cell lineage specification, and increasing evidence indicates that the nanoscale geometry/topography of the extracellular matrix (ECM) directs stem cell fate. Recently, many three-dimensional (3D) biomimetic nanofibrous scaffolds resembling many characteristics of the native ECM have been used in stem cell-based myocardial tissue engineering. However, the biophysical role and underlying mechanism of 3D nanofibrous scaffolds in cardiomyocyte differentiation of induced pluripotent stem cells (iPSCs) remain unclear.