Development of an acetylspiramycin sensor based on a single-walled carbon nanotubes film electrode

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• 作者：Yi Peng ; Ching Lu ; Bailing Hu ; Zhongbo Wang and Shengshui Hu
• 关键词：Key words ; Single ; walled carbon nanotubes ; acetylspiramycin ; chemically modified electrode ; voltammetry ; sensor.
• 刊名：Microchimica Acta
• 出版年：2007
• 出版时间：April, 2007
• 年：2007
• 卷：158
• 期：1-2
• 页码：79-84
• 全文大小：132 KB

文摘

A simple and sensitive sensor is described for the determination of acetylspiramycin (ASPM) based on a single-wall carbon nanotubes (SWNTs)-dihexadecyl hydrogen phosphate (DHP) film coated glassy carbon electrode (GCE). Compared with a bare GCE, the SWNTs-DHP film modified GCE exhibits excellent enhancement effects on the electrochemical oxidation of ASPM. A well-defined oxidation peak of ASPM occurs at 0.89 V in 0.1 mol¡¤L−1 phosphate buffer (pH 5.5), which was used to determine ASPM. The electrochemical behavior of ASPM at the SWNTs-DHP modified GCE was examined by cyclic voltammetry and differential pulse voltammetry. The experimental parameters were optimized and a direct electrochemical method for the determination of ASPM is proposed. Under optimum conditions, the oxidation peak current is linear to the concentration of ASPM in the range of 5.0–100 ¦Ìg¡¤mL−1, with a detection limit of 1 ¦Ìg¡¤mL−1. The SWNTs-DHP film modified electrode also provides an efficient way of eliminating interferences from some inorganic species in the solution. This sensor was successfully utilized to determine ASPM in drugs.