Therapeutic magnetic microcarriers characterization by measuring magnetophoretic attributes.

详细信息   

• 作者：Vidal Ibacache ; Guillermo.
• 学历：Master
• 年：2013
• 毕业院校：Ecole Polytechnique
• Department：Software Engineering.
• ISBN：9781321160796
• CBH：1528213
• Country：France
• 语种：English
• FileSize：1743441
• Pages：100

文摘

Micro/nano robots are considered a promising approach to conduct minimally invasive interventions. We have proposed to embed magnetic nanoparticles in therapeutic or diagnostic agents in order to magnetically control them. A modified clinical Magnetic Resonance Imaging MRI) scanner is used to provide the driving force that allows these magnetically embedded microcarriers to navigate the vascular human network. By using specific Magnetic Resonance MR) gradient sequences this method has been validated in previous research works. Magnetophoresis is the term used to describe the fact that a magnetic particle changes its trajectory under the influence of a magnetic force while being carried by a fluid flow. This movement depends on the particles magnetic characteristics,the particles geometric shape,the fluid flows attributes and other factors. In our proposed method,magnetic microcarriers can be produced in several different ways,and so their response will differ to the same magnetic force and fluid flow conditions. The outcome of the therapeutic treatment using our method depends on the adequate selection of the therapeutic and/or diagnosis agents to be used. The selected therapeutic and/or diagnosis magnetic microcarrier also influences the selection of the MR gradient sequence that best fit for a given treatment. This masters thesis presents the design of a device intended to assess the magnetophoretic properties of magnetic therapeutic microcarriers and/or diagnostic agents. Such characterization is essential for determining the optimal sequences of magnetic gradients to deflect their trajectory through relatively complex vascular networks in order to reach a pre-defined target. A microfluidic device was fabricated to validate the design. Magnetophoretic velocities are measured and a simple tracking method is proposed. The preliminary experimental results indicate that,despite some limitations,the proposed technique has the potential to be appropriate to characterize any drug and/or diagnosis magnetic microcarrier containing different magnetic nanoparticle content.