The antitumor triterpene glycosides from the sea cucumber Pearsonothuria graeffei
- 作者：Ping DongYang-hua YiJing-feng WangShi-long ZhangChang-hu Xue
- 会议时间：2007-08-01
- 关键词：Pearsonothuria graeffei ; sea cucumber ; triterpene glycosides ; antitumor activity
- 作者单位：Ping Dong,Jing-feng Wang,Chang-hu Xue(College of Food Science and Technology,Ocean University of China,No.5,Yu Shan Roaa,Qingdao,Shandong Province,266003,P.R.China)Yang-hua Yi,Shi-long Zhang(Research Center for Marine Drugs,School of Pharmacy,Second Military Medical University,No.325,Guo He Road,Shanghai,200433,P.R.China)
- 母体文献：2008全国博士生学术论坛——海洋、水产领域论文集
- 会议名称：2008全国博士生学术论坛——海洋、水产领域
- 会议地点：青岛
- 主办单位：国务院学位办
- 语种：chi
- 分类号：O6;P7
摘要
Triterpene glycosides from the sea cucumber Pearsonothuria graeffei showed excellent antitumor activities for several cancer cell lines,the IC50 values of crude glycosides were range from 8.17 to 10.78μg/ml.It should be noticed that the triterpene glycosides in this kind of sea cucumber is very abundant,the yield of crude glycosides was more than 100mg / g dry weight of Pearsonothuria graeffei.Eight triterpene glycosides were isolated and structure established from Pearsonothuria graeffei for the first time.