原发性颅内生殖细胞肿瘤125例临床诊治分析
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摘要
目的总结原发性颅内生殖细胞肿瘤的临床特征及治疗方法。方法原发性颅内生殖细胞肿瘤125例,依据2007年WHO中枢神经系统肿瘤分类标准,对其临床资料进行回顾性分析。结果 125例病人中,肿瘤呈单发生长113例,多病灶12例,其中肿瘤起源于松果体区69例、鞍上区44例、基底节区12例。病人平均年龄14.4岁,男女之比为2.9∶1.0。年轻病人的5年生存率优于年龄较大者。局部放射治疗病人的5年生存率低于扩大范围放射治疗者。结论原发性颅内生殖细胞瘤有明显的临床特征,全面综合分析病人的临床特征有助于明确诊断。早期而适当的干预,部分病人有望取得理想预后。
Objective To investigate the clinical characteristic and therapeutic methods of primary intracranial germ cell tumors( ICGCTs). Methods According to the WHO 2007 classification for CNS tumors,125 cases of primary intracranial germ cell tumors admitted into the Hospital were analyzed retrospectively. Results There were 113 cases of singlefocal tumors and 12 cases of multifocal tumors.There were 69 tumors originated from pineal region,44 in suprasellar region,12 in basal ganglia region.The average age of all the patients was 14. 4 years. And the ratio of male-female was 2. 9∶ 1. 0 in all cases.The younger patients demonstrated a slightly more favourable overall survival than their older counterparts.Patients treated with local field irradiation appeared to have shorter 5 years overall survival compared to patients who had extended field RT( WBRT/WVRT/CSI). Conclusion The clinical characteristic of primary intracranial germ cell tumors were distinctive from other intracranial tumors,comprehensive analysis of clinical data may lead to an exact diagnosis. More than half of patients with ICGCTs may acquire ideal results with early and appropriate intervention.
Objective To investigate the clinical characteristic and therapeutic methods of primary intracranial germ cell tumors( ICGCTs). Methods According to the WHO 2007 classification for CNS tumors,125 cases of primary intracranial germ cell tumors admitted into the Hospital were analyzed retrospectively. Results There were 113 cases of singlefocal tumors and 12 cases of multifocal tumors.There were 69 tumors originated from pineal region,44 in suprasellar region,12 in basal ganglia region.The average age of all the patients was 14. 4 years. And the ratio of male-female was 2. 9∶ 1. 0 in all cases.The younger patients demonstrated a slightly more favourable overall survival than their older counterparts.Patients treated with local field irradiation appeared to have shorter 5 years overall survival compared to patients who had extended field RT( WBRT/WVRT/CSI). Conclusion The clinical characteristic of primary intracranial germ cell tumors were distinctive from other intracranial tumors,comprehensive analysis of clinical data may lead to an exact diagnosis. More than half of patients with ICGCTs may acquire ideal results with early and appropriate intervention.
引文
[1]Nakamura H,Makino K,Yano S,et al.Epidemiological study of primary intracranial tumors:a regional survey in Kumamoto prefecture in southern Japan-20-year study[J].Int J Clin Oncol,2011,16(4):314-321.
[2]Villano JL,Virk IY,Ramirez V,et al.Descriptive epidemiology of central nervous system germ cell tumors:nonpineal analysis[J].Neuro Oncol,2010,12(3):257-264.
[3]Foo AS,Lim C,Chong DQ,et al.Primary intracranial germ cell tumours:Experience of a single South-East Asian institution[J].J Clin Neurosci,2014,21(10):1761-1766.
[4]Mc Carthy BJ,Shibui S,Kayama T,et al.Primary CNS germ cell tumors in Japan and the United States:an analysis of 4 tumor registries[J].Neuro Oncol,2012,14(9):1194-1200.
[5]Matsutani M,Sano K,Takakura K,et al.Primary intracranial germ cell tumors:a clinical analysis of 153 histologically verified cases[J].J Neurosurg,1997,86(3):446-455.
[6]Chen YW,Huang PI,Ho DM,et al.Change in treatment strategy for intracranial germinoma:long-term follow-up experience at a single institute[J].Cancer,2012,118(10):2752-2762.
[7]Alapetite C,Brisse H,Patte C,et al.Pattern of relapse and outcome of nonmetastatic germinoma patents treated with chemotherapy and limited field radiation:the SFOP experience[J].Neuro Oncol,2010,12(2):1318-1325.
[8]Calaminus G,Kortmann R,Worch J,et al.SIOP CNS GCT 96:final report of outcome of a prospective,multinational nonrandomized trial for children and adults with intracranial germinoma,comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease[J].Neuro Oncol,2013,15(6):788-796.
[2]Villano JL,Virk IY,Ramirez V,et al.Descriptive epidemiology of central nervous system germ cell tumors:nonpineal analysis[J].Neuro Oncol,2010,12(3):257-264.
[3]Foo AS,Lim C,Chong DQ,et al.Primary intracranial germ cell tumours:Experience of a single South-East Asian institution[J].J Clin Neurosci,2014,21(10):1761-1766.
[4]Mc Carthy BJ,Shibui S,Kayama T,et al.Primary CNS germ cell tumors in Japan and the United States:an analysis of 4 tumor registries[J].Neuro Oncol,2012,14(9):1194-1200.
[5]Matsutani M,Sano K,Takakura K,et al.Primary intracranial germ cell tumors:a clinical analysis of 153 histologically verified cases[J].J Neurosurg,1997,86(3):446-455.
[6]Chen YW,Huang PI,Ho DM,et al.Change in treatment strategy for intracranial germinoma:long-term follow-up experience at a single institute[J].Cancer,2012,118(10):2752-2762.
[7]Alapetite C,Brisse H,Patte C,et al.Pattern of relapse and outcome of nonmetastatic germinoma patents treated with chemotherapy and limited field radiation:the SFOP experience[J].Neuro Oncol,2010,12(2):1318-1325.
[8]Calaminus G,Kortmann R,Worch J,et al.SIOP CNS GCT 96:final report of outcome of a prospective,multinational nonrandomized trial for children and adults with intracranial germinoma,comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease[J].Neuro Oncol,2013,15(6):788-796.