麻杏石甘汤合葶苈大枣泻肺汤加减治疗小儿肺炎的效果
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摘要
目的:探究小儿肺炎患儿行麻杏石甘汤联合葶苈大枣泻肺汤治疗的临床效果。方法:选取2017年7月-2018年6月本院儿科收治的56例小儿肺炎患儿为研究对象。根据患儿入院时间先后顺序将其分为对照组和观察组,各28例。对照组开展常规西药治疗,观察组在对照组基础上行麻杏石甘汤联合葶苈大枣泻肺汤治疗。比较两组临床疗效、不良反应发生率、临床症状消退时间、住院时间以及治疗前后肺功能指标。结果:观察组临床总有效率为92.86%,高于对照组的71.43%(P<0.05);观察组不良反应发生率为10.71%,低于对照组的35.71%(P<0.05);观察组咳嗽、发热、喘憋及肺啰音等临床症状消退时间及住院时间均少于对照组(P<0.05);治疗后,观察组肺功能指标均高于对照组(P<0.05)。结论:麻杏石甘汤联合葶苈大枣泻肺汤治疗小儿肺炎临床效果理想,不良反应发生率低,且可有效缩短患儿临床症消退时间及住院时间,能够改善患儿肺功能,对患儿的康复具有积极影响,因此该种治疗方案值得在临床中进行推广应用。
Objective:To investigate the clinical effect of Maxing Shigan Decoction combined with Tingli Dazao Xiefei Decoction in treatment of infantile pneumonia.Method:A total of 56 children with pneumonia from July 2017 to June 2018 were selected.According to the time of admission,they were divided into control group and observation group,28 cases in each group.The control group was treated with routine western medicine,while observation group was treated with Maxing Shigan Decoction combined with Tingli Dazao Xiefei Decoction on the basis of control group.The clinical efficacy,the incidence of adverse reactions,the time of clinical symptoms subsidence,the length of hospitalization and the indexes of pulmonary function before and after treatment between two groups were compared.Result:The total clinical effective rate of observation group was 92.86%,which was higher than 71.43% of control group(P<0.05).The incidence of adverse reactions in observation group was 10.71%,which was lower than 35.71% in control group(P<0.05).The clinical symptoms such as cough,fever,wheezing and lung rale in observation group were less than those of control group(P<0.05).After treatment,the pulmonary function indexes in observation group were higher than those of control group(P<0.05).Conclusion:Maxing Shigan Decoction combined with Tingli Dazao Xiefei Decoction has ideal clinical effect in treatment of infantile pneumonia with low incidence of adverse reactions,it can effectively shorten the time of clinical symptoms subsidence and hospitalization,improve the pulmonary function of children,and have a positive impact on the rehabilitation of children,it is worth popularizing and applying in clinical practice.
Objective:To investigate the clinical effect of Maxing Shigan Decoction combined with Tingli Dazao Xiefei Decoction in treatment of infantile pneumonia.Method:A total of 56 children with pneumonia from July 2017 to June 2018 were selected.According to the time of admission,they were divided into control group and observation group,28 cases in each group.The control group was treated with routine western medicine,while observation group was treated with Maxing Shigan Decoction combined with Tingli Dazao Xiefei Decoction on the basis of control group.The clinical efficacy,the incidence of adverse reactions,the time of clinical symptoms subsidence,the length of hospitalization and the indexes of pulmonary function before and after treatment between two groups were compared.Result:The total clinical effective rate of observation group was 92.86%,which was higher than 71.43% of control group(P<0.05).The incidence of adverse reactions in observation group was 10.71%,which was lower than 35.71% in control group(P<0.05).The clinical symptoms such as cough,fever,wheezing and lung rale in observation group were less than those of control group(P<0.05).After treatment,the pulmonary function indexes in observation group were higher than those of control group(P<0.05).Conclusion:Maxing Shigan Decoction combined with Tingli Dazao Xiefei Decoction has ideal clinical effect in treatment of infantile pneumonia with low incidence of adverse reactions,it can effectively shorten the time of clinical symptoms subsidence and hospitalization,improve the pulmonary function of children,and have a positive impact on the rehabilitation of children,it is worth popularizing and applying in clinical practice.
引文
[1]柯玲玲,卞显辉,傅亚瑜,等.中医药治疗小儿肺炎研究进展[J].中医药临床杂志,2016,28(10):1488-1492.
[2]范建红,范小康.穴位敷贴如意金黄散治疗对肺炎患儿临床症状改善情况及肺功能的影响[J].光明中医,2018,33(21):3198-3199,3259.
[3]郑宝英,闫超,薛冠华,等.耐药肺炎支原体肺炎患儿的临床特点及流行基因型特征分析[J].中华实用儿科临床杂志,2017,32(10):735-739.
[4]田沁.抗生素降阶梯疗法在重症肺炎患儿中的临床效果及安全性分析[J].临床肺科杂志,2016,21(6):1038-1040.
[5]胡磊,周春,徐湘.麻杏石甘汤联合西药治疗小儿支气管肺炎的疗效观察及对炎症指标的影响[J].中国妇幼保健,2018,33(12):2738-2740.
[6]朱嵘,杜强.金水宝胶囊联合布地奈德福莫特罗粉吸入剂治疗高风险慢性阻塞性肺疾病的临床疗效[J].实用心脑肺血管病杂志,2016,24(10):114-117.
[7]于红权.麻杏石甘汤对支原体肺炎患儿血清炎症因子、免疫球蛋白水平影响及临床治疗效果研究[J].陕西中医,2018,39(3):292-294.
[8]边红恩,陈团营,单海军.麻杏石甘汤联合阿奇霉素对小儿支原体肺炎患儿抗炎、促炎因子及免疫功能的影响[J].中国实验方剂学杂志,2017,23(22):177-181.
[9]张忠浩,徐婉洁.小儿呼吸系统疾病静脉常用非抗菌药物的不良反应及处理对策[J].中国临床医生杂志,2016,44(3):19-22.
[10]张涛,樊点莲.抗生素的药物不良反应发生率及临床合理用药研究[J].中国药物与临床,2017,17(2):278-279.
[11]代如民,陈爽,张彦博.五虎汤合葶苈大枣泻肺汤加减治疗新生儿支原体肺炎痰热闭肺证临床研究[J].中医学报,2017,32(3):348-351.
[12]武三麟.中医临床运用辨时施治2案[J].天津中医药,2014,31(12):734.
[13]姜德友,姜培培.肺痿源流考[J].浙江中医药大学学报,2015,39(1):15-18,21.
[14]王保芹,朱洁,李泽庚.甘草在方剂中的作用及配伍规律[J].长春中医药大学学报,2017,33(1):52-54.
[15]杨志军,邓毅,曼琼,等.甘草水煎液和内生菌止咳祛痰作用的比较研究[J].中国临床药理学杂志,2017,33(12):1143-1148.
[16]曹少从,于水源,王旭亮,等.张仲景使用大枣刍议[J].长春中医药大学学报,2017,33(3):499-501.
[17]辛小红,范雪梅,张凯.张仲景肺系疾病用药规律研究[J].中国中医急症,2014,23(1):45-47.
[18]李文劲.宣肺涤痰方内服外敷辅助治疗小儿肺炎喘嗽(痰热闭肺证)疗效观察[J].中国中医急症,2016,25(12):2326-2328.
[19]姜茗宸,徐秋月,汪小蓉.汪受传应用葶苈子泻肺涤痰降气平喘治疗小儿肺系疾病经验[J].中华中医药杂志,2018,33(6):2407-2409.
[20]顾敏勇,尚莉丽,孙彦丽.健脾补肺化痰方对小儿支气管哮喘缓解期肺功能的影响[J].广州中医药大学学报,2016,33(1):8-11.
[2]范建红,范小康.穴位敷贴如意金黄散治疗对肺炎患儿临床症状改善情况及肺功能的影响[J].光明中医,2018,33(21):3198-3199,3259.
[3]郑宝英,闫超,薛冠华,等.耐药肺炎支原体肺炎患儿的临床特点及流行基因型特征分析[J].中华实用儿科临床杂志,2017,32(10):735-739.
[4]田沁.抗生素降阶梯疗法在重症肺炎患儿中的临床效果及安全性分析[J].临床肺科杂志,2016,21(6):1038-1040.
[5]胡磊,周春,徐湘.麻杏石甘汤联合西药治疗小儿支气管肺炎的疗效观察及对炎症指标的影响[J].中国妇幼保健,2018,33(12):2738-2740.
[6]朱嵘,杜强.金水宝胶囊联合布地奈德福莫特罗粉吸入剂治疗高风险慢性阻塞性肺疾病的临床疗效[J].实用心脑肺血管病杂志,2016,24(10):114-117.
[7]于红权.麻杏石甘汤对支原体肺炎患儿血清炎症因子、免疫球蛋白水平影响及临床治疗效果研究[J].陕西中医,2018,39(3):292-294.
[8]边红恩,陈团营,单海军.麻杏石甘汤联合阿奇霉素对小儿支原体肺炎患儿抗炎、促炎因子及免疫功能的影响[J].中国实验方剂学杂志,2017,23(22):177-181.
[9]张忠浩,徐婉洁.小儿呼吸系统疾病静脉常用非抗菌药物的不良反应及处理对策[J].中国临床医生杂志,2016,44(3):19-22.
[10]张涛,樊点莲.抗生素的药物不良反应发生率及临床合理用药研究[J].中国药物与临床,2017,17(2):278-279.
[11]代如民,陈爽,张彦博.五虎汤合葶苈大枣泻肺汤加减治疗新生儿支原体肺炎痰热闭肺证临床研究[J].中医学报,2017,32(3):348-351.
[12]武三麟.中医临床运用辨时施治2案[J].天津中医药,2014,31(12):734.
[13]姜德友,姜培培.肺痿源流考[J].浙江中医药大学学报,2015,39(1):15-18,21.
[14]王保芹,朱洁,李泽庚.甘草在方剂中的作用及配伍规律[J].长春中医药大学学报,2017,33(1):52-54.
[15]杨志军,邓毅,曼琼,等.甘草水煎液和内生菌止咳祛痰作用的比较研究[J].中国临床药理学杂志,2017,33(12):1143-1148.
[16]曹少从,于水源,王旭亮,等.张仲景使用大枣刍议[J].长春中医药大学学报,2017,33(3):499-501.
[17]辛小红,范雪梅,张凯.张仲景肺系疾病用药规律研究[J].中国中医急症,2014,23(1):45-47.
[18]李文劲.宣肺涤痰方内服外敷辅助治疗小儿肺炎喘嗽(痰热闭肺证)疗效观察[J].中国中医急症,2016,25(12):2326-2328.
[19]姜茗宸,徐秋月,汪小蓉.汪受传应用葶苈子泻肺涤痰降气平喘治疗小儿肺系疾病经验[J].中华中医药杂志,2018,33(6):2407-2409.
[20]顾敏勇,尚莉丽,孙彦丽.健脾补肺化痰方对小儿支气管哮喘缓解期肺功能的影响[J].广州中医药大学学报,2016,33(1):8-11.