非创伤性股骨头坏死与脂质代谢紊乱的机制研究进展
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摘要
非创伤性股骨头坏死是由于股骨头血供受损或者中断引起骨细胞和骨髓成分死亡,继而导致股骨头结构改变甚至塌陷,引起髋关节疼痛及严重功能障碍的一种疾病。酗酒和滥用激素是引起非创伤性股骨头坏死的常见病因,但关于其具体发病机制的研究目前仍存在多种理论假说,主要包括脂质代谢紊乱学说、骨质疏松学说、骨内压增高学说以及血管内凝血学说等,其中脂质代谢紊乱学说在众多观点中具有较高的认可度。本研究在查阅相关文献的基础上,围绕脂质代谢紊乱与非创伤性股骨头坏死的发病机制进行分析总结,以期对临床或实验研究非创伤性股骨头坏死相关问题提供一定的借鉴和参考。
引文
[1]周明旺,李盛华,王晓萍,等.平和质酒精性股骨头坏死患者CYP4501A2*1C基因多态性研究[J].中国中医骨伤科杂志,2014(11):9-12.
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[3]李盛华,周明旺,郭铁峰,等.血瘀质非创伤性股骨头坏死基因多态性研究[J].中国中医药信息杂志,2016,23(11):17-21.
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[5]Pengde K,Fuxing P,Bin S,et al.Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits[J].Joint Bone Spine,2008,75(6):696-701.
[6]Zhang G,Qin L,Sheng H,et al.Anovel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner[J].Bone,2009,44(2):345.
[7]陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社,2008.
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[13]Weldon D.The effects of corticosteroids on bone:osteonecrosis(avascular necrosis of the bone)[J].Annals of Allergy Asthma&Immunology,2009,103(2):91-98.
[14]黄可,唐毓金.酒精性股骨头坏死脂代谢异常的研究进展[J].中国医药指南,2013(9):73-75.
[15]Malizos KN,Karantanas AH,Varitimidis SE,et al.Osteonecrosis of the femoral head:etiology,imaging and treatment[J].European Journal of Radiology,2007,63(1):16.
[16]石少辉,李子荣,孙伟,等.酒精性和激素性股骨头坏死的发病与脂质代谢[J].中国组织工程研究,2011,15(17):3217-3220.
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[18]Tan G,Kang PD,Pei FX.Glucocorticoids affect the metabolism of bone marrow stromal cell sand lead toosteonecrosis of the femoral head[J].Chinese Medical Journal,2012,125(1):134-139.
[19]Bujalska I J,Kumar S,Hewison M,et al.Differentiation of adipose stromal cells:the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase[J].Endocrinology,1999,140(7):3188.
[20]Ren D,Collingwood TN,Rebar EJ,et al.PPARγknockdown by engineered transcription factors:exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis[J].Genes&Development,2002,16(1):27.
[21]Nakashima K,Zhou X,Kunkel G,et al.The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation[J].Cell,2002,108(1):17-29.
[22]童培建,肖鲁伟,季卫锋,等.脂质代谢及破骨细胞活性在激素性股骨头坏死塌陷发生过程中的作用研究[J].中国骨伤,2009,22(2):110-113.
[23]Wu L,Wang T,Ge Y,et al.Secreted factors fromadipose tissue increase adipogenic differentiation of mesenchymal stem cells[J].Cell Proliferation,2012,45(4):311-319.
[24]Kim HK,Randall TS,Bian H,et al.Ibandronate for prevention offemoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs[J].Journal of Bone&Joint Surgery American Volume,2005,87(3):550-557.
[25]Li X,Jin L,Cui Q,et al.Steroid effects on osteogenesis through mesenchymal cell gene expression[J].Osteoporosis international,2005,16(1):101.
[26]崔操,李厚成,郭一行,等.激素性股骨头坏死微血管变化及高压氧治疗机制的研究[J].中华航海医学与高气压医学杂志,2014,21(1):59-63.
[27]Weinstein RS,O'Brien CA,Almeida M,et al.Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice[J].Endocrinology,2011,152(9):3323-3331.
[28]Ito S,Suzuki N,Kato S,et al.Glucocorticoids induce the differentiation of a mesenchymal progenitor cell line,ROB-C26 into adipocytes and osteoblasts,but fail to induce terminal osteoblast differentiation[J].Bone,2007,40(1):84.
[29]Rodríguez JP,Montecinos L,Ríos S,et al.Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation[J].Journal of Cellular Biochemistry,2000,79(4):557-565.
[30]刘铁,苏庆军,藏磊,等.股骨头缺血性坏死与局部微环境瘦素表达的相关性研究[J].中国修复重建外科杂志,2012,26(11):1319-1323.
[31]Kitajima M,Shigematsu M,Ogawa K,et al.Effects of glucocorticoid on adipocyte size in human bone marrow[J].Medical Molecular Morphology,2007,40(3):150.
[32]Ducy P,Amling M,Takeda S,et al.Leptin inhibits bone formation through a hypothalamic relay:a central control of bone mass[J].Cell,2000,100(2):197-207.
[33]Mohanty ST,Kottam L,Gambardella A,et al.Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis[J].Arthritis Research&Therapy,2010,12(4):R149.
[34]Wei C,Zhang Z,Ming N,et al.Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head[J].Biomed Research International,2015,2015(3):196495.
[2]汪亮,刘耀升,刘蜀彬.糖皮质激素诱导股骨头坏死发病机制的研究进展[J].中华损伤与修复杂志:电子版,2015,10(5):60-66.
[3]李盛华,周明旺,郭铁峰,等.血瘀质非创伤性股骨头坏死基因多态性研究[J].中国中医药信息杂志,2016,23(11):17-21.
[4]Moon JG,Shetty GM,Biswal S,et al.Alcohol-induced multifocal osteonecrosis:a case report with 14-year follow-up[J].Archives of Orthopaedic&Trauma Surgery,2008,128(10):1149-1152.
[5]Pengde K,Fuxing P,Bin S,et al.Lovastatin inhibits adipogenesis and prevents osteonecrosis in steroid-treated rabbits[J].Joint Bone Spine,2008,75(6):696-701.
[6]Zhang G,Qin L,Sheng H,et al.Anovel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner[J].Bone,2009,44(2):345.
[7]陆再英,钟南山.内科学[M].第7版.北京:人民卫生出版社,2008.
[8]Hirahara K,Kano Y,Asano Y,et al.Osteonecrosis ofthe femoral head in a patient with Henoch-Sch觟nlein purpura and drug-induced hypersensitivity syndrome treated with corticosteroids[J].Actadermato-venereologica,2013,93(1):85-86.
[9]Shapiro F,Connolly S,Zurakowski D,et al.Femoral head deformation and repair following induction of ischemic necrosis a histologic and magnetic resonance imaging study in the piglet[J].Journal of Bone&Joint Surgery American Volume,2009,91(12):2903-2914.
[10]张义福,刘建,孟国林,等.兔激素性股骨头坏死病程中肝脂肪酶改变的意义[J].医学争鸣,2006,27(8):737-740.
[11]Sen RK,Tripathy SK,Aggarwal S,et al.Earlyresults ofcore decompression and autologous bone marrow mononuclear cells instillation in femoral head osteonecrosis:a randomized control study[J].Journal of Arthroplasty,2012,27(5):679-686.
[12]Nozaki Y,Kumagai K,Miyata N,et al.Pravastatin reduces steroid-inducedosteonecrosisofthefemoralheadinSHRSPrats[J].ActaOrthopaedica,2012,83(1):87-92.
[13]Weldon D.The effects of corticosteroids on bone:osteonecrosis(avascular necrosis of the bone)[J].Annals of Allergy Asthma&Immunology,2009,103(2):91-98.
[14]黄可,唐毓金.酒精性股骨头坏死脂代谢异常的研究进展[J].中国医药指南,2013(9):73-75.
[15]Malizos KN,Karantanas AH,Varitimidis SE,et al.Osteonecrosis of the femoral head:etiology,imaging and treatment[J].European Journal of Radiology,2007,63(1):16.
[16]石少辉,李子荣,孙伟,等.酒精性和激素性股骨头坏死的发病与脂质代谢[J].中国组织工程研究,2011,15(17):3217-3220.
[17]林玉珊,陈丽.酒精性骨质疏松模型鼠的血流动力学及氧自由基代谢特征[J].中国当代医药,2009,16(5):30-31.
[18]Tan G,Kang PD,Pei FX.Glucocorticoids affect the metabolism of bone marrow stromal cell sand lead toosteonecrosis of the femoral head[J].Chinese Medical Journal,2012,125(1):134-139.
[19]Bujalska I J,Kumar S,Hewison M,et al.Differentiation of adipose stromal cells:the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase[J].Endocrinology,1999,140(7):3188.
[20]Ren D,Collingwood TN,Rebar EJ,et al.PPARγknockdown by engineered transcription factors:exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis[J].Genes&Development,2002,16(1):27.
[21]Nakashima K,Zhou X,Kunkel G,et al.The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation[J].Cell,2002,108(1):17-29.
[22]童培建,肖鲁伟,季卫锋,等.脂质代谢及破骨细胞活性在激素性股骨头坏死塌陷发生过程中的作用研究[J].中国骨伤,2009,22(2):110-113.
[23]Wu L,Wang T,Ge Y,et al.Secreted factors fromadipose tissue increase adipogenic differentiation of mesenchymal stem cells[J].Cell Proliferation,2012,45(4):311-319.
[24]Kim HK,Randall TS,Bian H,et al.Ibandronate for prevention offemoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs[J].Journal of Bone&Joint Surgery American Volume,2005,87(3):550-557.
[25]Li X,Jin L,Cui Q,et al.Steroid effects on osteogenesis through mesenchymal cell gene expression[J].Osteoporosis international,2005,16(1):101.
[26]崔操,李厚成,郭一行,等.激素性股骨头坏死微血管变化及高压氧治疗机制的研究[J].中华航海医学与高气压医学杂志,2014,21(1):59-63.
[27]Weinstein RS,O'Brien CA,Almeida M,et al.Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice[J].Endocrinology,2011,152(9):3323-3331.
[28]Ito S,Suzuki N,Kato S,et al.Glucocorticoids induce the differentiation of a mesenchymal progenitor cell line,ROB-C26 into adipocytes and osteoblasts,but fail to induce terminal osteoblast differentiation[J].Bone,2007,40(1):84.
[29]Rodríguez JP,Montecinos L,Ríos S,et al.Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation[J].Journal of Cellular Biochemistry,2000,79(4):557-565.
[30]刘铁,苏庆军,藏磊,等.股骨头缺血性坏死与局部微环境瘦素表达的相关性研究[J].中国修复重建外科杂志,2012,26(11):1319-1323.
[31]Kitajima M,Shigematsu M,Ogawa K,et al.Effects of glucocorticoid on adipocyte size in human bone marrow[J].Medical Molecular Morphology,2007,40(3):150.
[32]Ducy P,Amling M,Takeda S,et al.Leptin inhibits bone formation through a hypothalamic relay:a central control of bone mass[J].Cell,2000,100(2):197-207.
[33]Mohanty ST,Kottam L,Gambardella A,et al.Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis[J].Arthritis Research&Therapy,2010,12(4):R149.
[34]Wei C,Zhang Z,Ming N,et al.Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head[J].Biomed Research International,2015,2015(3):196495.