醒脑开窍中药对高血压脑出血患者的临床效果
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摘要
目的:探讨醒脑开窍中药对高血压脑出血患者的临床疗效。方法:收集2011年12月-2017年12月在我院就诊的脑出血患者80例,根据随机数字表分为对照组和干预组,各40例。两组患者均进行定向硬通道微创血肿引流术,干预组的患者在对照组的基础上,在术后1天开始口服醒脑开窍中药进行治疗,口服2周。观察两组患者的血液流变学指标和颅内压,从而判断醒脑开窍中药对高血压脑出血患者的临床疗效。结果:干预组血液流变学中的所有指标均显著低于对照组,且差异具有统计学意义(P <0.05)。干预组治疗后的颅内压显著低于对照组,且差异具有统计学意义(P <0.05)。结论:醒脑开窍中药对高血压脑出血患者有明显的改善作用,可以调节患者血液理化性质,降低血液黏稠度,有利于增加患者脑部血流量,保护脑组织,值得在临床上进一步研究。
Objective: To explore the clinical effect of TCM medicine for Xingnao Kaiqiao(醒脑开窍) on hypertensive cerebral hemorrhage. Methods: 80 patients with cerebral hemorrhage were randomly divided into the two groups, 40 cases in each. The patients in both groups were treated by stereotactic hard channel minimally invasive hematoma evacuation; and the intervention group was given TCM medicine for 2 weeks after the surgery. The hemorheology index and intracranial pressure in the two groups were observed, to determine the clinical efficacy of TCM medicine on hypertensive cerebral hemorrhage. Results: The hemorheology index and intracranial pressure in the intervention group after treatment was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion: TCM medicine for Xingnao Kaiqiao shows a significant improvement effect on patients with hypertensive cerebral hemorrhage. It can regulate the physicochemical properties of blood, reduce blood viscosity, increase blood flow in the brain, protect brain tissue, and is worthy of further research in clinical practice.
Objective: To explore the clinical effect of TCM medicine for Xingnao Kaiqiao(醒脑开窍) on hypertensive cerebral hemorrhage. Methods: 80 patients with cerebral hemorrhage were randomly divided into the two groups, 40 cases in each. The patients in both groups were treated by stereotactic hard channel minimally invasive hematoma evacuation; and the intervention group was given TCM medicine for 2 weeks after the surgery. The hemorheology index and intracranial pressure in the two groups were observed, to determine the clinical efficacy of TCM medicine on hypertensive cerebral hemorrhage. Results: The hemorheology index and intracranial pressure in the intervention group after treatment was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion: TCM medicine for Xingnao Kaiqiao shows a significant improvement effect on patients with hypertensive cerebral hemorrhage. It can regulate the physicochemical properties of blood, reduce blood viscosity, increase blood flow in the brain, protect brain tissue, and is worthy of further research in clinical practice.
引文
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[7]Schlunk F,Greenberg SM.The Pathophysiology of Intracerebral HemorrhageFormation and Expansion[J].Transl Stroke Res,2015,6(04):257-263.
[8]Yang J,Arima H,Wu G,et al.Prognostic significance of perihematomal edema in acute intracerebral hemorrhage:pooled analysis from the intensive blood pressure reduction in acute cerebral hemorrhage trial studies[J].Stroke,2015,46(04):1009-1013.
[2]陈国永,吴润华,陈学华,等.手术治疗高血压脑出血患者再次出血的影响因素[J].江西医药,2017,52(02):107-109.
[3]Gushcha AO,Semenov MS,Lepsveridze LT.Experience of endoscopic removal of hypertensive intracerebral hemorrhage[J].Zh Vopr Neirokhir Im N N Burdenko,2015,79(06):71-76.
[4]王会改.通心络胶囊治疗高血压脑出血的临床研究[J].海南医学院学报,2014,20(12):1625-1626,1629.
[5]Yang G,Shao G.Clinical effect of minimally invasive intracranial hematoma in treating hypertensive cerebral hemorrhage[J].Pak J Med Sci,2016,32(03):677-681.
[6]高慧娟.急性脑出血患者血液流变学改变的临床研究[D].太原:山西医科大学,2006:71-75.
[7]Schlunk F,Greenberg SM.The Pathophysiology of Intracerebral HemorrhageFormation and Expansion[J].Transl Stroke Res,2015,6(04):257-263.
[8]Yang J,Arima H,Wu G,et al.Prognostic significance of perihematomal edema in acute intracerebral hemorrhage:pooled analysis from the intensive blood pressure reduction in acute cerebral hemorrhage trial studies[J].Stroke,2015,46(04):1009-1013.