辐射相关microRNA研究进展
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摘要
微小RNA(miRNA)是一类长度为21~25核苷酸(nt)的单链非编码小RNA分子,它们普遍存在于真核细胞内。大量研究发现,辐射可以诱导一系列miRNA分子的表达,辐射诱导的miRNA与辐射损伤及光损伤、辐射的敏感性、辐射诱导肿瘤的发生和辐射旁观者效应有着密切的关系。本文概述辐射诱导miRNA的研究进展,旨在为放射病的防护和肿瘤放疗提供新思路。
MicroRNAs(miRNAs)are small single-stranded noncoding RNAs consisting of 21-25 nucleotides that are widespread in the eukaryotic cells. A lot of research found that the radiation may induce the expression of a series of miRNAs molecules,miRNAs have a close relationship with radiation damage or light damage,radiation sensitive,the occurrence of tumors induced by radiation and the bystander effect. The research progress on radiation-induced miRNAs is reviewed in this paper,and its target is to provide a new thinking for the protection of radiation sickness and radiotherapy of tumor.
MicroRNAs(miRNAs)are small single-stranded noncoding RNAs consisting of 21-25 nucleotides that are widespread in the eukaryotic cells. A lot of research found that the radiation may induce the expression of a series of miRNAs molecules,miRNAs have a close relationship with radiation damage or light damage,radiation sensitive,the occurrence of tumors induced by radiation and the bystander effect. The research progress on radiation-induced miRNAs is reviewed in this paper,and its target is to provide a new thinking for the protection of radiation sickness and radiotherapy of tumor.
引文
[1]黄景义.辐射的危害与健康防护[J].西藏科技,2008(8):28-30.
[2]JENNIFER S,DICKEY FJ,ZEMP OA,et al. The role of miRNA in the direct and indirect effects of ionizing radiation[J/OL]. Radiat Environ Biophys,2011(50):491–499.[2018-06-19].https://www.ncbi.nlm.nih.gov/pubmed/?term=21928045. DOI:10.1007/s00411-011-0386-5.
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[5]CUI FM,SUN XJ,DING X,et al. Differential Expression Profiles of microRNAs in Mice Internally Exposed to Tritiated Water[J]. Toxicological&Environmental chemistry,2011,93(4):738-751.
[6]孙秀锦,崔凤梅,黄铖铖,等.60Coγ射线照射致小鼠肝脏的miRNAs表达改变[J].中华放射医学与防护杂志,2011,31(1):20-23.
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[11]华丽娟. microRNA146a在UVB诱导的机型光损伤中作用机制的研究[D].南京:南京医科大学,2011:4-6.
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[14] YOSHIMURA M,ITASAKA S,HARADA H,et al. Microenvironment and radiation therapy[J/OL]. Biomed Res Int,2013,2013:685308.[2018-03-19].https://www.researchgate.net/publication/300636629_Microenvironment_and_radiation_therapy.DOI:10.2217/fmeb2014. 14.37.
[15]程赢,和生辉,刘聪,等.辐射诱导性miR-34a的表达对细胞辐射敏感性的影响[J].第二军医大学学报,2011,32(4):368.
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[17]徐珊,燕蒙蒙,刘扬,等. miR-21对宫颈癌HeLa细胞辐射敏感性的影响[J].吉林大学学报(医学版),2014,40(6):1138-1143.
[18]狄英波,薛茗方,刘雅娟,等. miR-21在辐射敏感性不同的3种乳腺癌细胞株中的表达差异及意义[J].中国妇幼保健,2013,28(9):1499-1501.
[19]刘聪.miRNA在辐射致癌中德作用及其辐射生物学效应研究[D].上海:第二军医大学,2010:1-7.
[20]MENG F,HENSON R,WEHBE-JANEK H,et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer[J/OL]. Gastroenterology,2007,133:647-658. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285346.DOI:10.1053/j.gastro.2007.05.022.
[21] MOTHERSILL C,SEYMOUR C. Radiation-induced bystander effects:past history and future directions[J]. Radiat Res,2001,155(6):759-767.
[22]BALLARINI F,BIAGGI M,OTTOLENGHI A,et al. Cellular communication and bystander effects:a critical review for modelling lowdose radiation action[J].Mutat Res,2002,501(1-2):1-12.
[23] PRISE KM,O’SULLIVAN JM. Radiation-induced bystander signalling in cancer therapy[J].Nat Rev Cancer,2009,9(5):351.
[24]KOVALCHUK O,ZEMP FJ,FILKOWSKI JN,et al. MicroRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways[J]. Carcinogenesis,2010,31(10):1882-1888.
[25]XU S,DING N,PEI H,et al. MiR-21 is involved in radiation-induced bystander effects[J]. RNA Biol,2014,11(9):1161-1170.
[26]WENTAO H,SHUAI X,BIN Y,et al. MiR-663 inhibits radiation-induced bystander effects by targeti ng TGFB1 in a feedback mode[J].RNA Biology,2014,11(9):1189-1198.
[2]JENNIFER S,DICKEY FJ,ZEMP OA,et al. The role of miRNA in the direct and indirect effects of ionizing radiation[J/OL]. Radiat Environ Biophys,2011(50):491–499.[2018-06-19].https://www.ncbi.nlm.nih.gov/pubmed/?term=21928045. DOI:10.1007/s00411-011-0386-5.
[3]ILNYTSKYY Y,ZEMP FJ,KOTURBASH I,et al. Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sexspecific protective mechanism[J]. Biochem Biophys Res Commun,2008,377(1):41-45.
[4]MECHTHILD WE,CHRISTIAN S,UTE W,et al. MicroRNA expression after ionizing radiation in human endothelial cells[J]. Radiation Oncology,2010,5(25):1-10.
[5]CUI FM,SUN XJ,DING X,et al. Differential Expression Profiles of microRNAs in Mice Internally Exposed to Tritiated Water[J]. Toxicological&Environmental chemistry,2011,93(4):738-751.
[6]孙秀锦,崔凤梅,黄铖铖,等.60Coγ射线照射致小鼠肝脏的miRNAs表达改变[J].中华放射医学与防护杂志,2011,31(1):20-23.
[7]MARSIT CJ,EDDY K,KELSEY KT. MicroRNA Responses to Cellular Stress[J]. Cancer Res,2006,66(22):10843-10848.
[8]ISHII H,SAITO T. Radiation-induced response of microRNA expression in murine embryonic stem cells[J]. Med Chem,2006,2(6):555-563.
[9]MAES OC,AN J,SAROJINI H,et al. Changes in MicroRNA Expression Patterns in Human Fibroblasts After Low-LET Radiation[J]. J Cell Biochem,2008,105(3):824-834.
[10]夏寿萱.放射生物学[M].北京:军事医学科学出版社,1998:1-21.
[11]华丽娟. microRNA146a在UVB诱导的机型光损伤中作用机制的研究[D].南京:南京医科大学,2011:4-6.
[12]李巍,华丽娟,周炳荣,等.UVB诱导HaCaT细胞急性光损伤中miRNA141作用机制的研究[C]. 2011年全国中西医结合皮肤性病学术会议论文汇编,昆明,2011:25-26.
[13]SUN X,LIU H. Identification and characterization of a small inhibitory peptide that can target DNA-PKcs autophosphorylation and increase tumor radiosensitivity[J]. Int J Radiat Oncol Biol Phys,2012,84(5):1212-1219.
[14] YOSHIMURA M,ITASAKA S,HARADA H,et al. Microenvironment and radiation therapy[J/OL]. Biomed Res Int,2013,2013:685308.[2018-03-19].https://www.researchgate.net/publication/300636629_Microenvironment_and_radiation_therapy.DOI:10.2217/fmeb2014. 14.37.
[15]程赢,和生辉,刘聪,等.辐射诱导性miR-34a的表达对细胞辐射敏感性的影响[J].第二军医大学学报,2011,32(4):368.
[16]WANG J,HE J,SU F,et al. Repression of ATR pathway by miR-185enhances radiation-induced apoptosis and proliferation inhibition[J/OL].Cell Death Dis. 2013,4:e699. http://xueshu.baidu.com/s?wd=Repression+of+ATR+pathway+by+miR-185+enhances+radiation-induced+apoptosis+and+proliferation+inhibition&rsv_bp=0&tn=SE_baiduxueshu_c1gjeupa&rsv_spt=3&ie=utf-8&f=8&rsv_sug2=1&sc_f_para=sc_tasktype%3D%7BfirstSimpleSearch%7D.DOI:10.1038/cddis.2013.227.
[17]徐珊,燕蒙蒙,刘扬,等. miR-21对宫颈癌HeLa细胞辐射敏感性的影响[J].吉林大学学报(医学版),2014,40(6):1138-1143.
[18]狄英波,薛茗方,刘雅娟,等. miR-21在辐射敏感性不同的3种乳腺癌细胞株中的表达差异及意义[J].中国妇幼保健,2013,28(9):1499-1501.
[19]刘聪.miRNA在辐射致癌中德作用及其辐射生物学效应研究[D].上海:第二军医大学,2010:1-7.
[20]MENG F,HENSON R,WEHBE-JANEK H,et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer[J/OL]. Gastroenterology,2007,133:647-658. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285346.DOI:10.1053/j.gastro.2007.05.022.
[21] MOTHERSILL C,SEYMOUR C. Radiation-induced bystander effects:past history and future directions[J]. Radiat Res,2001,155(6):759-767.
[22]BALLARINI F,BIAGGI M,OTTOLENGHI A,et al. Cellular communication and bystander effects:a critical review for modelling lowdose radiation action[J].Mutat Res,2002,501(1-2):1-12.
[23] PRISE KM,O’SULLIVAN JM. Radiation-induced bystander signalling in cancer therapy[J].Nat Rev Cancer,2009,9(5):351.
[24]KOVALCHUK O,ZEMP FJ,FILKOWSKI JN,et al. MicroRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways[J]. Carcinogenesis,2010,31(10):1882-1888.
[25]XU S,DING N,PEI H,et al. MiR-21 is involved in radiation-induced bystander effects[J]. RNA Biol,2014,11(9):1161-1170.
[26]WENTAO H,SHUAI X,BIN Y,et al. MiR-663 inhibits radiation-induced bystander effects by targeti ng TGFB1 in a feedback mode[J].RNA Biology,2014,11(9):1189-1198.